Platelet-surface glycoproteins in healthy and preeclamptic mothers and their newborn infants
(1996) In Pediatric Research 40(6). p.876-880- Abstract
Preeclampsia, a common complication of pregnancy, contributes significantly to maternal and fetal morbidity and mortality. It may lead to both quantitative and qualitative defects of maternal and neonatal platelets. In this prospective study, flow cytometry has been used to study expression of platelet-surface glycoproteins (GPs) on maternal and neonatal platelets of both healthy and preeclamptic subjects. We studied 15 preeclamptic women, 20- 44 y of age, and their newborns (median gestational age, 32 wk; range, 26- 38) and seven healthy women (aged 26-41 y) and their healthy newborns (median gestational age, 38 wk; range, 38-42). Compared with their healthy and preeclamptic mothers, resting platelets from neonates expressed... (More)
Preeclampsia, a common complication of pregnancy, contributes significantly to maternal and fetal morbidity and mortality. It may lead to both quantitative and qualitative defects of maternal and neonatal platelets. In this prospective study, flow cytometry has been used to study expression of platelet-surface glycoproteins (GPs) on maternal and neonatal platelets of both healthy and preeclamptic subjects. We studied 15 preeclamptic women, 20- 44 y of age, and their newborns (median gestational age, 32 wk; range, 26- 38) and seven healthy women (aged 26-41 y) and their healthy newborns (median gestational age, 38 wk; range, 38-42). Compared with their healthy and preeclamptic mothers, resting platelets from neonates expressed significantly less CD41 and CD9. Thrombin activation resulted in significant increases in platelet-surface expression of CD62P, CD63, CD41, CD9, and CD36 in neonates and their healthy mothers. Compared with neonates of healthy mothers, platelets from neonates of preeclamptic mothers expressed lower levels of CD62P, CD63, CD9, and CD36 on activated platelets. These findings suggest that preeclampsia influences the expression of platelet-surface GPs on neonatal and maternal platelets, which may affect platelet function, leading to an additional risk for bleeding in thrombocytopenic neonates of mothers with preeclampsia.
(Less)
- author
- Kühne, Thomas ; Ryan, Greg ; Blanchette, Victor ; Semple, John W. LU ; Hornstein, Adriana ; Mody, Meera ; Chang, Wilda ; Mcwhirter, Lindsay and Freedman, John
- publishing date
- 1996-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Pediatric Research
- volume
- 40
- issue
- 6
- pages
- 5 pages
- publisher
- International Pediatric Foundation Inc.
- external identifiers
-
- scopus:0029808426
- pmid:8947966
- ISSN
- 0031-3998
- DOI
- 10.1203/00006450-199612000-00018
- language
- English
- LU publication?
- no
- id
- d93153ae-68ee-438f-93bd-4967dfedde3f
- date added to LUP
- 2019-12-03 10:32:07
- date last changed
- 2024-01-02 01:19:07
@article{d93153ae-68ee-438f-93bd-4967dfedde3f,
abstract = {{<p>Preeclampsia, a common complication of pregnancy, contributes significantly to maternal and fetal morbidity and mortality. It may lead to both quantitative and qualitative defects of maternal and neonatal platelets. In this prospective study, flow cytometry has been used to study expression of platelet-surface glycoproteins (GPs) on maternal and neonatal platelets of both healthy and preeclamptic subjects. We studied 15 preeclamptic women, 20- 44 y of age, and their newborns (median gestational age, 32 wk; range, 26- 38) and seven healthy women (aged 26-41 y) and their healthy newborns (median gestational age, 38 wk; range, 38-42). Compared with their healthy and preeclamptic mothers, resting platelets from neonates expressed significantly less CD41 and CD9. Thrombin activation resulted in significant increases in platelet-surface expression of CD62P, CD63, CD41, CD9, and CD36 in neonates and their healthy mothers. Compared with neonates of healthy mothers, platelets from neonates of preeclamptic mothers expressed lower levels of CD62P, CD63, CD9, and CD36 on activated platelets. These findings suggest that preeclampsia influences the expression of platelet-surface GPs on neonatal and maternal platelets, which may affect platelet function, leading to an additional risk for bleeding in thrombocytopenic neonates of mothers with preeclampsia.</p>}},
author = {{Kühne, Thomas and Ryan, Greg and Blanchette, Victor and Semple, John W. and Hornstein, Adriana and Mody, Meera and Chang, Wilda and Mcwhirter, Lindsay and Freedman, John}},
issn = {{0031-3998}},
language = {{eng}},
month = {{01}},
number = {{6}},
pages = {{876--880}},
publisher = {{International Pediatric Foundation Inc.}},
series = {{Pediatric Research}},
title = {{Platelet-surface glycoproteins in healthy and preeclamptic mothers and their newborn infants}},
url = {{http://dx.doi.org/10.1203/00006450-199612000-00018}},
doi = {{10.1203/00006450-199612000-00018}},
volume = {{40}},
year = {{1996}},
}