Cellular immune mechanisms in autoimmune thrombocytopenic purpura : An update
(2003) In Transfusion Medicine Reviews 17(1). p.69-80- Abstract
Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system (RES), particularly in the spleen. The production of IgG autoantibodies is critically dependent on cellular immune mechanisms particularly relating to T cells. We review the recent literature of the cell-mediated immunology of AITP focusing on platelet phenotype, genetics, T-cell reactivities, and cytokine profiles in patients with AITP. Understanding the interaction between these cell-mediated mechanisms is vital for developing antigen specific immunotherapies to... (More)
Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system (RES), particularly in the spleen. The production of IgG autoantibodies is critically dependent on cellular immune mechanisms particularly relating to T cells. We review the recent literature of the cell-mediated immunology of AITP focusing on platelet phenotype, genetics, T-cell reactivities, and cytokine profiles in patients with AITP. Understanding the interaction between these cell-mediated mechanisms is vital for developing antigen specific immunotherapies to treat this autoimmune disease.
(Less)
- author
- Coopamah, Malini D. ; Garvey, M. Bernadette ; Freedman, John and Semple, John W. LU
- publishing date
- 2003-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Transfusion Medicine Reviews
- volume
- 17
- issue
- 1
- pages
- 69 - 80
- publisher
- Elsevier
- external identifiers
-
- scopus:0037228342
- pmid:12522773
- ISSN
- 0887-7963
- DOI
- 10.1053/tmrv.2003.50004
- language
- English
- LU publication?
- no
- id
- d977a533-f00b-4713-a754-febc89fdb91b
- date added to LUP
- 2019-12-03 10:24:07
- date last changed
- 2024-05-15 03:07:42
@article{d977a533-f00b-4713-a754-febc89fdb91b, abstract = {{<p>Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system (RES), particularly in the spleen. The production of IgG autoantibodies is critically dependent on cellular immune mechanisms particularly relating to T cells. We review the recent literature of the cell-mediated immunology of AITP focusing on platelet phenotype, genetics, T-cell reactivities, and cytokine profiles in patients with AITP. Understanding the interaction between these cell-mediated mechanisms is vital for developing antigen specific immunotherapies to treat this autoimmune disease.</p>}}, author = {{Coopamah, Malini D. and Garvey, M. Bernadette and Freedman, John and Semple, John W.}}, issn = {{0887-7963}}, language = {{eng}}, number = {{1}}, pages = {{69--80}}, publisher = {{Elsevier}}, series = {{Transfusion Medicine Reviews}}, title = {{Cellular immune mechanisms in autoimmune thrombocytopenic purpura : An update}}, url = {{http://dx.doi.org/10.1053/tmrv.2003.50004}}, doi = {{10.1053/tmrv.2003.50004}}, volume = {{17}}, year = {{2003}}, }