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Cellular immune mechanisms in autoimmune thrombocytopenic purpura : An update

Coopamah, Malini D. ; Garvey, M. Bernadette ; Freedman, John and Semple, John W. LU (2003) In Transfusion Medicine Reviews 17(1). p.69-80
Abstract

Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system (RES), particularly in the spleen. The production of IgG autoantibodies is critically dependent on cellular immune mechanisms particularly relating to T cells. We review the recent literature of the cell-mediated immunology of AITP focusing on platelet phenotype, genetics, T-cell reactivities, and cytokine profiles in patients with AITP. Understanding the interaction between these cell-mediated mechanisms is vital for developing antigen specific immunotherapies to... (More)

Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system (RES), particularly in the spleen. The production of IgG autoantibodies is critically dependent on cellular immune mechanisms particularly relating to T cells. We review the recent literature of the cell-mediated immunology of AITP focusing on platelet phenotype, genetics, T-cell reactivities, and cytokine profiles in patients with AITP. Understanding the interaction between these cell-mediated mechanisms is vital for developing antigen specific immunotherapies to treat this autoimmune disease.

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Please use this url to cite or link to this publication:
author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Transfusion Medicine Reviews
volume
17
issue
1
pages
69 - 80
publisher
W.B. Saunders
external identifiers
  • scopus:0037228342
  • pmid:12522773
ISSN
0887-7963
DOI
10.1053/tmrv.2003.50004
language
English
LU publication?
no
id
d977a533-f00b-4713-a754-febc89fdb91b
date added to LUP
2019-12-03 10:24:07
date last changed
2025-10-17 14:14:45
@article{d977a533-f00b-4713-a754-febc89fdb91b,
  abstract     = {{<p>Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system (RES), particularly in the spleen. The production of IgG autoantibodies is critically dependent on cellular immune mechanisms particularly relating to T cells. We review the recent literature of the cell-mediated immunology of AITP focusing on platelet phenotype, genetics, T-cell reactivities, and cytokine profiles in patients with AITP. Understanding the interaction between these cell-mediated mechanisms is vital for developing antigen specific immunotherapies to treat this autoimmune disease.</p>}},
  author       = {{Coopamah, Malini D. and Garvey, M. Bernadette and Freedman, John and Semple, John W.}},
  issn         = {{0887-7963}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{69--80}},
  publisher    = {{W.B. Saunders}},
  series       = {{Transfusion Medicine Reviews}},
  title        = {{Cellular immune mechanisms in autoimmune thrombocytopenic purpura : An update}},
  url          = {{http://dx.doi.org/10.1053/tmrv.2003.50004}},
  doi          = {{10.1053/tmrv.2003.50004}},
  volume       = {{17}},
  year         = {{2003}},
}