From COPD epidemiology to studies of pathophysiological disease mechanisms : challenges with regard to study design and recruitment process: Respiratory and Cardiovascular Effects in COPD (KOLIN)

Lindberg, Anne; Linder, Robert; Backman, Helena; Eriksson Ström, Jonas; Frølich, Andreas; Nilsson, Ulf; Rönmark, Eva; Strandkvist, Viktor; Behndig, Annelie F.; Blomberg, Anders

From COPD epidemiology to studies of pathophysiological disease mechanisms : challenges with regard to study design and recruitment process: Respiratory and Cardiovascular Effects in COPD (KOLIN)

Mark

; Backman, Helena ; Eriksson Ström, Jonas ; Frølich, Andreas ; Nilsson, Ulf ; Rönmark, Eva ; Strandkvist, Viktor ; Behndig, Annelie F. and Blomberg, Anders (2017) In European clinical respiratory journal 4(1).

Abstract: Background: Chronic obstructive pulmonary disease (COPD) is a largely underdiagnosed disease including several phenotypes. In this report, the design of a study intending to evaluate the pathophysiological mechanism in COPD in relation to the specific phenotypes non-rapid and rapid decline in lung function is described together with the recruitment process of the study population derived from a population based study. Method: The OLIN COPD study includes a population-based COPD cohort and referents without COPD identified in 2002–04 (n = 1986), and thereafter followed annually since 2005. Lung function decline was estimated from baseline in 2002–2004 to 2010 (first recruitment phase) or to 2012/2013 (second recruitment phase).... (More); Background: Chronic obstructive pulmonary disease (COPD) is a largely underdiagnosed disease including several phenotypes. In this report, the design of a study intending to evaluate the pathophysiological mechanism in COPD in relation to the specific phenotypes non-rapid and rapid decline in lung function is described together with the recruitment process of the study population derived from a population based study. Method: The OLIN COPD study includes a population-based COPD cohort and referents without COPD identified in 2002–04 (n = 1986), and thereafter followed annually since 2005. Lung function decline was estimated from baseline in 2002–2004 to 2010 (first recruitment phase) or to 2012/2013 (second recruitment phase). Individuals who met the predefined criteria for the following four groups were identified; group A) COPD grade 2–3 with rapid decline in FEV₁ and group B) COPD grade 2–3 without rapid decline in FEV₁ (≥60 and ≤30 ml/year, respectively), group C) ever-smokers, and group D) non-smokers with normal lung function. Groups A–C included ever-smokers with >10 pack years. The intention was to recruit 15 subjects in each of the groups A-D. Results: From the database groups A–D were identified; group A n = 37, group B n = 29, group C n = 41, and group D n = 55. Fifteen subjects were recruited from groups C and D, while this goal was not reached in the groups A (n = 12) and B (n = 10). The most common reasons for excluding individuals identified as A or B were comorbidities contraindicating bronchoscopy, or inflammatory diseases/immune suppressive medication expected to affect the outcome. Conclusion: The study is expected to generate important results regarding pathophysiological mechanisms associated with rate of decline in lung function among subjects with COPD and the in-detail described recruitment process, including reasons for non-participation, is a strength when interpreting the results in forthcoming studies.
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Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/d9843cf8-3df0-4d2c-9026-12007e267382

author

Lindberg, Anne ; Linder, Robert ^LU

; Backman, Helena ; Eriksson Ström, Jonas ; Frølich, Andreas ; Nilsson, Ulf ; Rönmark, Eva ; Strandkvist, Viktor ; Behndig, Annelie F. and Blomberg, Anders

publishing date

2017-12-17

type

Contribution to journal

publication status

published

subject

Respiratory Medicine and Allergy

keywords

Chronic obstructive pulmonary disease, disease mechanisms, lung function decline, smoking habits, Chronic obstructive pulmonary disease (COPD), KOL, disease mechanisms, sjukdomsmekanismer, Lung function decline, lunfunktionsförsämring, Smoking habits, rökvanor

in

European clinical respiratory journal

volume

4

issue

1

article number

1415095

publisher

Taylor & Francis

external identifiers

scopus:85058074357

ISSN

2001-8525

DOI

10.1080/20018525.2017.1415095

language

English

LU publication?

no

additional info

id

d9843cf8-3df0-4d2c-9026-12007e267382

date added to LUP

2025-05-16 09:52:36

date last changed

2025-05-16 13:54:16

@article{d9843cf8-3df0-4d2c-9026-12007e267382,
  abstract     = {{<p>Background: Chronic obstructive pulmonary disease (COPD) is a largely underdiagnosed disease including several phenotypes. In this report, the design of a study intending to evaluate the pathophysiological mechanism in COPD in relation to the specific phenotypes non-rapid and rapid decline in lung function is described together with the recruitment process of the study population derived from a population based study. Method: The OLIN COPD study includes a population-based COPD cohort and referents without COPD identified in 2002–04 (n = 1986), and thereafter followed annually since 2005. Lung function decline was estimated from baseline in 2002–2004 to 2010 (first recruitment phase) or to 2012/2013 (second recruitment phase). Individuals who met the predefined criteria for the following four groups were identified; group A) COPD grade 2–3 with rapid decline in FEV<sub>1</sub> and group B) COPD grade 2–3 without rapid decline in FEV<sub>1</sub> (≥60 and ≤30 ml/year, respectively), group C) ever-smokers, and group D) non-smokers with normal lung function. Groups A–C included ever-smokers with &gt;10 pack years. The intention was to recruit 15 subjects in each of the groups A-D. Results: From the database groups A–D were identified; group A n = 37, group B n = 29, group C n = 41, and group D n = 55. Fifteen subjects were recruited from groups C and D, while this goal was not reached in the groups A (n = 12) and B (n = 10). The most common reasons for excluding individuals identified as A or B were comorbidities contraindicating bronchoscopy, or inflammatory diseases/immune suppressive medication expected to affect the outcome. Conclusion: The study is expected to generate important results regarding pathophysiological mechanisms associated with rate of decline in lung function among subjects with COPD and the in-detail described recruitment process, including reasons for non-participation, is a strength when interpreting the results in forthcoming studies.</p>}},
  author       = {{Lindberg, Anne and Linder, Robert and Backman, Helena and Eriksson Ström, Jonas and Frølich, Andreas and Nilsson, Ulf and Rönmark, Eva and Strandkvist, Viktor and Behndig, Annelie F. and Blomberg, Anders}},
  issn         = {{2001-8525}},
  keywords     = {{Chronic obstructive pulmonary disease; disease mechanisms; lung function decline; smoking habits; Chronic obstructive pulmonary disease (COPD); KOL; disease mechanisms; sjukdomsmekanismer; Lung function decline; lunfunktionsförsämring; Smoking habits; rökvanor}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{1}},
  publisher    = {{Taylor & Francis}},
  series       = {{European clinical respiratory journal}},
  title        = {{From COPD epidemiology to studies of pathophysiological disease mechanisms : challenges with regard to study design and recruitment process: Respiratory and Cardiovascular Effects in COPD (KOLIN)}},
  url          = {{http://dx.doi.org/10.1080/20018525.2017.1415095}},
  doi          = {{10.1080/20018525.2017.1415095}},
  volume       = {{4}},
  year         = {{2017}},
}

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From COPD epidemiology to studies of pathophysiological disease mechanisms : challenges with regard to study design and recruitment process: Respiratory and Cardiovascular Effects in COPD (KOLIN)