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RIFM fragrance ingredient safety assessment, isobutyl propionate, CAS Registry Number 540-42-1

Api, A. M. ; Belsito, D. ; Botelho, D. ; Bruze, M. LU ; Burton, G. A. ; Buschmann, J. ; Dagli, M. L. ; Date, M. ; Dekant, W. and Deodhar, C. , et al. (2019) In Food and Chemical Toxicology 130(suppl 1).
Abstract

Summary: The existing information supports the use of this material as described in this safety assessment. Isobutyl propionate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog isobutyl acetate (CAS # 110-19-0) show that isobutyl propionate is not expected to be genotoxic. Data from read-across analog isoamyl acetate (CAS # 123-92-2) show that there are no safety concerns for isobutyl propionate for skin sensitization under the current declared levels of use. The repeated dose and reproductive endpoints were evaluated using the TTC for a Cramer Class I material, and the... (More)

Summary: The existing information supports the use of this material as described in this safety assessment. Isobutyl propionate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog isobutyl acetate (CAS # 110-19-0) show that isobutyl propionate is not expected to be genotoxic. Data from read-across analog isoamyl acetate (CAS # 123-92-2) show that there are no safety concerns for isobutyl propionate for skin sensitization under the current declared levels of use. The repeated dose and reproductive endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to isobutyl propionate is below the TTC (0.03 mg/kg/day and 0.03 mg/kg/day, respectively). For the local respiratory endpoint, a calculated MOE >100 was provided by read-across analog butyl acetate (CAS # 123-86-4). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; isobutyl propionate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; isobutyl propionate is not PBT as per the IFRA Environmental Standards. For the risk assessment, isobutyl propionate was not able to be risk screened as there were no reported volumes of use for North America or Europe in the 2015 IFRA Survey.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Developmental, and reproductive toxicity, Environmental Safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization
in
Food and Chemical Toxicology
volume
130
issue
suppl 1
article number
110607
publisher
Elsevier
external identifiers
  • scopus:85068579222
  • pmid:31233870
ISSN
0278-6915
DOI
10.1016/j.fct.2019.110607
language
English
LU publication?
no
id
d9a191d7-ceeb-457e-9784-4b5853b33940
date added to LUP
2019-07-22 11:24:45
date last changed
2024-04-30 18:15:04
@article{d9a191d7-ceeb-457e-9784-4b5853b33940,
  abstract     = {{<p>Summary: The existing information supports the use of this material as described in this safety assessment. Isobutyl propionate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog isobutyl acetate (CAS # 110-19-0) show that isobutyl propionate is not expected to be genotoxic. Data from read-across analog isoamyl acetate (CAS # 123-92-2) show that there are no safety concerns for isobutyl propionate for skin sensitization under the current declared levels of use. The repeated dose and reproductive endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to isobutyl propionate is below the TTC (0.03 mg/kg/day and 0.03 mg/kg/day, respectively). For the local respiratory endpoint, a calculated MOE &gt;100 was provided by read-across analog butyl acetate (CAS # 123-86-4). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; isobutyl propionate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; isobutyl propionate is not PBT as per the IFRA Environmental Standards. For the risk assessment, isobutyl propionate was not able to be risk screened as there were no reported volumes of use for North America or Europe in the 2015 IFRA Survey.</p>}},
  author       = {{Api, A. M. and Belsito, D. and Botelho, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Dagli, M. L. and Date, M. and Dekant, W. and Deodhar, C. and Francis, M. and Fryer, A. D. and Jones, L. and Joshi, K. and La Cava, S. and Lapczynski, A. and Liebler, D. C. and O'Brien, D. and Patel, A. and Penning, T. M. and Ritacco, G. and Romine, J. and Sadekar, N. and Salvito, D. and Schultz, T. W. and Sipes, I. G. and Sullivan, G. and Thakkar, Y. and Tokura, Y. and Tsang, S.}},
  issn         = {{0278-6915}},
  keywords     = {{Developmental, and reproductive toxicity; Environmental Safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose; Skin sensitization}},
  language     = {{eng}},
  number       = {{suppl 1}},
  publisher    = {{Elsevier}},
  series       = {{Food and Chemical Toxicology}},
  title        = {{RIFM fragrance ingredient safety assessment, isobutyl propionate, CAS Registry Number 540-42-1}},
  url          = {{http://dx.doi.org/10.1016/j.fct.2019.110607}},
  doi          = {{10.1016/j.fct.2019.110607}},
  volume       = {{130}},
  year         = {{2019}},
}