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Successful Photopatch Testing with Ketoprofen Using One-Hour Occlusion.

Marmgren, Victoria LU ; Hindsén, Monica LU ; Zimerson, Erik LU and Bruze, Magnus (2011) In Acta Dermato-Venereologica 91. p.131-136
Abstract
The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatch testing with ketoprofen. A total of 22 patients with a known or suspected photo-allergy to ketoprofen were simultaneously photopatch-tested with ketoprofen using both 1 h and 24 h occlusion. One side of the patient's back was irradiated with 5 J/cm2 UVA, and the other side was covered. Measurements were made after 3 days on both irradiated and... (More)
The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatch testing with ketoprofen. A total of 22 patients with a known or suspected photo-allergy to ketoprofen were simultaneously photopatch-tested with ketoprofen using both 1 h and 24 h occlusion. One side of the patient's back was irradiated with 5 J/cm2 UVA, and the other side was covered. Measurements were made after 3 days on both irradiated and non-irradiated sides. A total of 20 controls were photopatch-tested with ketoprofen using 1 h occlusion. All of the patients showed positive reactions on the irradiated side. No positive reactions were observed on the non-irradiated side. All controls were negative. In conclusion, 1 h occlusion time is sufficient to establish photo-contact allergy to ketoprofen. No adjustments in UVA or ketoprofen dose were needed. Limiting occlu-sion time to 1 h could simplify the photopatch test procedure by eliminating one visit to the clinic. These results apply only to ketoprofen; further studies are needed to determine whether a similar approach can be used with other components of photopatch test series. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Dermato-Venereologica
volume
91
pages
131 - 136
publisher
Medical Journals Limited
external identifiers
  • wos:000289042900003
  • pmid:21327321
  • scopus:79952366717
ISSN
1651-2057
DOI
10.2340/00015555-1029
language
English
LU publication?
yes
id
d9f63c87-b743-4575-9824-275c1c0818cf (old id 1831735)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21327321?dopt=Abstract
date added to LUP
2016-04-04 09:31:03
date last changed
2022-01-29 18:16:19
@article{d9f63c87-b743-4575-9824-275c1c0818cf,
  abstract     = {{The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatch testing with ketoprofen. A total of 22 patients with a known or suspected photo-allergy to ketoprofen were simultaneously photopatch-tested with ketoprofen using both 1 h and 24 h occlusion. One side of the patient's back was irradiated with 5 J/cm2 UVA, and the other side was covered. Measurements were made after 3 days on both irradiated and non-irradiated sides. A total of 20 controls were photopatch-tested with ketoprofen using 1 h occlusion. All of the patients showed positive reactions on the irradiated side. No positive reactions were observed on the non-irradiated side. All controls were negative. In conclusion, 1 h occlusion time is sufficient to establish photo-contact allergy to ketoprofen. No adjustments in UVA or ketoprofen dose were needed. Limiting occlu-sion time to 1 h could simplify the photopatch test procedure by eliminating one visit to the clinic. These results apply only to ketoprofen; further studies are needed to determine whether a similar approach can be used with other components of photopatch test series.}},
  author       = {{Marmgren, Victoria and Hindsén, Monica and Zimerson, Erik and Bruze, Magnus}},
  issn         = {{1651-2057}},
  language     = {{eng}},
  pages        = {{131--136}},
  publisher    = {{Medical Journals Limited}},
  series       = {{Acta Dermato-Venereologica}},
  title        = {{Successful Photopatch Testing with Ketoprofen Using One-Hour Occlusion.}},
  url          = {{http://dx.doi.org/10.2340/00015555-1029}},
  doi          = {{10.2340/00015555-1029}},
  volume       = {{91}},
  year         = {{2011}},
}