Successful Photopatch Testing with Ketoprofen Using One-Hour Occlusion.
(2011) In Acta Dermato-Venereologica 91. p.131-136- Abstract
- The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatch testing with ketoprofen. A total of 22 patients with a known or suspected photo-allergy to ketoprofen were simultaneously photopatch-tested with ketoprofen using both 1 h and 24 h occlusion. One side of the patient's back was irradiated with 5 J/cm2 UVA, and the other side was covered. Measurements were made after 3 days on both irradiated and... (More)
- The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatch testing with ketoprofen. A total of 22 patients with a known or suspected photo-allergy to ketoprofen were simultaneously photopatch-tested with ketoprofen using both 1 h and 24 h occlusion. One side of the patient's back was irradiated with 5 J/cm2 UVA, and the other side was covered. Measurements were made after 3 days on both irradiated and non-irradiated sides. A total of 20 controls were photopatch-tested with ketoprofen using 1 h occlusion. All of the patients showed positive reactions on the irradiated side. No positive reactions were observed on the non-irradiated side. All controls were negative. In conclusion, 1 h occlusion time is sufficient to establish photo-contact allergy to ketoprofen. No adjustments in UVA or ketoprofen dose were needed. Limiting occlu-sion time to 1 h could simplify the photopatch test procedure by eliminating one visit to the clinic. These results apply only to ketoprofen; further studies are needed to determine whether a similar approach can be used with other components of photopatch test series. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1831735
- author
- Marmgren, Victoria LU ; Hindsén, Monica LU ; Zimerson, Erik LU and Bruze, Magnus
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Dermato-Venereologica
- volume
- 91
- pages
- 131 - 136
- publisher
- Medical Journals Limited
- external identifiers
-
- wos:000289042900003
- pmid:21327321
- scopus:79952366717
- ISSN
- 1651-2057
- DOI
- 10.2340/00015555-1029
- language
- English
- LU publication?
- yes
- id
- d9f63c87-b743-4575-9824-275c1c0818cf (old id 1831735)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21327321?dopt=Abstract
- date added to LUP
- 2016-04-04 09:31:03
- date last changed
- 2022-01-29 18:16:19
@article{d9f63c87-b743-4575-9824-275c1c0818cf, abstract = {{The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatch testing with ketoprofen. A total of 22 patients with a known or suspected photo-allergy to ketoprofen were simultaneously photopatch-tested with ketoprofen using both 1 h and 24 h occlusion. One side of the patient's back was irradiated with 5 J/cm2 UVA, and the other side was covered. Measurements were made after 3 days on both irradiated and non-irradiated sides. A total of 20 controls were photopatch-tested with ketoprofen using 1 h occlusion. All of the patients showed positive reactions on the irradiated side. No positive reactions were observed on the non-irradiated side. All controls were negative. In conclusion, 1 h occlusion time is sufficient to establish photo-contact allergy to ketoprofen. No adjustments in UVA or ketoprofen dose were needed. Limiting occlu-sion time to 1 h could simplify the photopatch test procedure by eliminating one visit to the clinic. These results apply only to ketoprofen; further studies are needed to determine whether a similar approach can be used with other components of photopatch test series.}}, author = {{Marmgren, Victoria and Hindsén, Monica and Zimerson, Erik and Bruze, Magnus}}, issn = {{1651-2057}}, language = {{eng}}, pages = {{131--136}}, publisher = {{Medical Journals Limited}}, series = {{Acta Dermato-Venereologica}}, title = {{Successful Photopatch Testing with Ketoprofen Using One-Hour Occlusion.}}, url = {{http://dx.doi.org/10.2340/00015555-1029}}, doi = {{10.2340/00015555-1029}}, volume = {{91}}, year = {{2011}}, }