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Microvascular Changes in Parkinson’s Disease- Focus on the Neurovascular Unit

Paul, Gesine LU and Elabi, Osama F. LU (2022) In Frontiers in Aging Neuroscience 14.
Abstract

Vascular alterations emerge as a common denominator for several neurodegenerative diseases. In Parkinson’s disease (PD), a number of observations have been made suggesting that the occurrence of vascular pathology is an important pathophysiological aspect of the disease. Specifically, pathological activation of pericytes, blood-brain barrier (BBB) disruption, pathological angiogenesis and vascular regression have been reported. This review summarizes the current evidence for the different vascular alterations in patients with PD and in animal models of PD. We suggest a possible sequence of vascular pathology in PD ranging from early pericyte activation and BBB leakage to an attempt for compensatory angiogenesis and finally vascular... (More)

Vascular alterations emerge as a common denominator for several neurodegenerative diseases. In Parkinson’s disease (PD), a number of observations have been made suggesting that the occurrence of vascular pathology is an important pathophysiological aspect of the disease. Specifically, pathological activation of pericytes, blood-brain barrier (BBB) disruption, pathological angiogenesis and vascular regression have been reported. This review summarizes the current evidence for the different vascular alterations in patients with PD and in animal models of PD. We suggest a possible sequence of vascular pathology in PD ranging from early pericyte activation and BBB leakage to an attempt for compensatory angiogenesis and finally vascular rarefication. We highlight different pathogenetic mechanisms that play a role in these vascular alterations including perivascular inflammation and concomitant metabolic disease. Awareness of the contribution of vascular events to the pathogenesis of PD may allow the identification of targets to modulate those mechanisms. In particular the BBB has for decades only been viewed as an obstacle for drug delivery, however, preservation of its integrity and/or modulation of the signaling at this interface between the blood and the brain may prove to be a new avenue to take in order to develop disease-modifying strategies for neurodegenerative disorders.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
angiogenesis, blood-brain barrier, microglia, Parkinson’s disease, pericytes, vasculature
in
Frontiers in Aging Neuroscience
volume
14
article number
853372
publisher
Frontiers Media S. A.
external identifiers
  • pmid:35360216
  • scopus:85127417880
ISSN
1663-4365
DOI
10.3389/fnagi.2022.853372
language
English
LU publication?
yes
id
d9f744dd-8232-4126-b5a8-0a836c41bf1f
date added to LUP
2022-05-04 12:04:42
date last changed
2024-06-13 12:19:35
@article{d9f744dd-8232-4126-b5a8-0a836c41bf1f,
  abstract     = {{<p>Vascular alterations emerge as a common denominator for several neurodegenerative diseases. In Parkinson’s disease (PD), a number of observations have been made suggesting that the occurrence of vascular pathology is an important pathophysiological aspect of the disease. Specifically, pathological activation of pericytes, blood-brain barrier (BBB) disruption, pathological angiogenesis and vascular regression have been reported. This review summarizes the current evidence for the different vascular alterations in patients with PD and in animal models of PD. We suggest a possible sequence of vascular pathology in PD ranging from early pericyte activation and BBB leakage to an attempt for compensatory angiogenesis and finally vascular rarefication. We highlight different pathogenetic mechanisms that play a role in these vascular alterations including perivascular inflammation and concomitant metabolic disease. Awareness of the contribution of vascular events to the pathogenesis of PD may allow the identification of targets to modulate those mechanisms. In particular the BBB has for decades only been viewed as an obstacle for drug delivery, however, preservation of its integrity and/or modulation of the signaling at this interface between the blood and the brain may prove to be a new avenue to take in order to develop disease-modifying strategies for neurodegenerative disorders.</p>}},
  author       = {{Paul, Gesine and Elabi, Osama F.}},
  issn         = {{1663-4365}},
  keywords     = {{angiogenesis; blood-brain barrier; microglia; Parkinson’s disease; pericytes; vasculature}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Aging Neuroscience}},
  title        = {{Microvascular Changes in Parkinson’s Disease- Focus on the Neurovascular Unit}},
  url          = {{http://dx.doi.org/10.3389/fnagi.2022.853372}},
  doi          = {{10.3389/fnagi.2022.853372}},
  volume       = {{14}},
  year         = {{2022}},
}