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Differences associated with age at onset in early systemic sclerosis patients : a report from the EULAR Scleroderma Trials and Research Group (EUSTAR) database

, ; Carreira, Patricia E; Carmona, L.; Joven, B. E.; Loza, E.; Andréu, J. L.; Riemekasten, G.; Vettori, S.; Balbir-Gurman, A. and Airò, P., et al. (2018) In Scandinavian Journal of Rheumatology
Abstract

Objective: The aim of this study was to analyse differences in clinical presentation in patients with early (< 3 years’ duration) systemic sclerosis (SSc), comparing three age groups according to disease subsets. Method: Cross-sectional analysis of the prospective EULAR Scleroderma Trials and Research database (EUSTAR) was performed. Patients fulfilling preliminary American College of Rheumatology 1980 classification criteria for SSc, with < 3 years from the first non-Raynaud’s SSc symptom at first entry, were selected. Patients with < 3 years from the first SSc symptom, including Raynaud’s phenomenon, were also analysed. SSc-related variables, including antibodies, SSc subsets, and organ involvement, were examined. Age was... (More)

Objective: The aim of this study was to analyse differences in clinical presentation in patients with early (< 3 years’ duration) systemic sclerosis (SSc), comparing three age groups according to disease subsets. Method: Cross-sectional analysis of the prospective EULAR Scleroderma Trials and Research database (EUSTAR) was performed. Patients fulfilling preliminary American College of Rheumatology 1980 classification criteria for SSc, with < 3 years from the first non-Raynaud’s SSc symptom at first entry, were selected. Patients with < 3 years from the first SSc symptom, including Raynaud’s phenomenon, were also analysed. SSc-related variables, including antibodies, SSc subsets, and organ involvement, were examined. Age was categorized into ≤ 30, 31–59, and ≥ 60 years. We performed descriptive and bivariate analyses. Results: The study included 1027 patients: 90% Caucasian, 80% women, and 40% with diffuse disease. In early stages of SSc, younger patients had significantly more anti-Scl-70 antibodies and diffuse disease. With increasing age, we observed more elevation of estimated pulmonary systolic pressure on echocardiography (5%, 13%, and 30%, respectively, in the three age groups), cardiac conduction blocks (6%, 6%, and 15%), and left ventricular diastolic dysfunction (4%, 12%, and 27%). The results were similar for 650 patients with < 3 years from first SSc symptom, including Raynaud’s. Conclusion: In early stages of SSc, older patients showed data indicating more severe disease with greater cardiac involvement. The diffuse subset was more frequent in the younger subgroup. The identification of such differences may help in selecting appropriate management for individual patients in clinical practice.

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Scandinavian Journal of Rheumatology
publisher
Taylor & Francis
external identifiers
  • scopus:85050532260
ISSN
0300-9742
DOI
10.1080/03009742.2018.1459830
language
English
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no
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da4d748b-93c6-4a82-8234-6d7dd8bacc8d
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2018-09-04 11:19:28
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2019-02-20 11:25:44
@article{da4d748b-93c6-4a82-8234-6d7dd8bacc8d,
  abstract     = {<p>Objective: The aim of this study was to analyse differences in clinical presentation in patients with early (&lt; 3 years’ duration) systemic sclerosis (SSc), comparing three age groups according to disease subsets. Method: Cross-sectional analysis of the prospective EULAR Scleroderma Trials and Research database (EUSTAR) was performed. Patients fulfilling preliminary American College of Rheumatology 1980 classification criteria for SSc, with &lt; 3 years from the first non-Raynaud’s SSc symptom at first entry, were selected. Patients with &lt; 3 years from the first SSc symptom, including Raynaud’s phenomenon, were also analysed. SSc-related variables, including antibodies, SSc subsets, and organ involvement, were examined. Age was categorized into ≤ 30, 31–59, and ≥ 60 years. We performed descriptive and bivariate analyses. Results: The study included 1027 patients: 90% Caucasian, 80% women, and 40% with diffuse disease. In early stages of SSc, younger patients had significantly more anti-Scl-70 antibodies and diffuse disease. With increasing age, we observed more elevation of estimated pulmonary systolic pressure on echocardiography (5%, 13%, and 30%, respectively, in the three age groups), cardiac conduction blocks (6%, 6%, and 15%), and left ventricular diastolic dysfunction (4%, 12%, and 27%). The results were similar for 650 patients with &lt; 3 years from first SSc symptom, including Raynaud’s. Conclusion: In early stages of SSc, older patients showed data indicating more severe disease with greater cardiac involvement. The diffuse subset was more frequent in the younger subgroup. The identification of such differences may help in selecting appropriate management for individual patients in clinical practice.</p>},
  author       = {,  and Carreira, Patricia E and Carmona, L. and Joven, B. E. and Loza, E. and Andréu, J. L. and Riemekasten, G. and Vettori, S. and Balbir-Gurman, A. and Airò, P. and Walker, U. and Damjanov, N. and Matucci-Cerinic, M. and Ananieva, L. P. and Rednic, Simona and Czirják, L. and Distler, Oliver and Farge, Dominique and Hesselstrand, R. and Corrado, A. and Caramaschi, Paola and Tikly, M. and Allanore, Yannick},
  issn         = {0300-9742},
  language     = {eng},
  month        = {01},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Rheumatology},
  title        = {Differences associated with age at onset in early systemic sclerosis patients : a report from the EULAR Scleroderma Trials and Research Group (EUSTAR) database},
  url          = {http://dx.doi.org/10.1080/03009742.2018.1459830},
  year         = {2018},
}