Transient synovitis of the hip in the child : Increased levels of proteoglycan fragments in joint fluid
(1988) In Journal of Orthopaedic Research 6(3). p.420-424- Abstract
The levels of proteoglycan antigen were measured in joint aspirates from the hip of children with transient synovitis, septic arthritis, Legg-Calve-Perthes' disease and congenital and traumatic dislocation. Significantly increased levels were found in children with transient synovitis and septic arthritis as compared with other conditions. We propose that the proteoglycan antigens in the joint fluid were released form the articular cartilage in a partially degraded from as a result of an increased rate of proteolytic degradation. In transient synovitis, the source of proteolytic activity may be chondrocytes activated by factors released by synovial cells. The release of joint proteoglycan may cause a temporary increase in deformability... (More)
The levels of proteoglycan antigen were measured in joint aspirates from the hip of children with transient synovitis, septic arthritis, Legg-Calve-Perthes' disease and congenital and traumatic dislocation. Significantly increased levels were found in children with transient synovitis and septic arthritis as compared with other conditions. We propose that the proteoglycan antigens in the joint fluid were released form the articular cartilage in a partially degraded from as a result of an increased rate of proteolytic degradation. In transient synovitis, the source of proteolytic activity may be chondrocytes activated by factors released by synovial cells. The release of joint proteoglycan may cause a temporary increase in deformability of the hip cartilage of the child that could be an important pathogenetic mechanism in some of the sequelae of these diseases.
(Less)
- author
- Lohmander, Stefan LU ; Wingstrand, H. LU and Heinegard, D.
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- child, hip, Transient synovitis
- in
- Journal of Orthopaedic Research
- volume
- 6
- issue
- 3
- pages
- 5 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:0023944153
- pmid:3357090
- ISSN
- 0736-0266
- language
- English
- LU publication?
- yes
- id
- da53c0fb-b259-4e7a-ab5c-cf97d2f40033
- date added to LUP
- 2016-05-04 13:09:33
- date last changed
- 2024-04-18 23:50:12
@article{da53c0fb-b259-4e7a-ab5c-cf97d2f40033, abstract = {{<p>The levels of proteoglycan antigen were measured in joint aspirates from the hip of children with transient synovitis, septic arthritis, Legg-Calve-Perthes' disease and congenital and traumatic dislocation. Significantly increased levels were found in children with transient synovitis and septic arthritis as compared with other conditions. We propose that the proteoglycan antigens in the joint fluid were released form the articular cartilage in a partially degraded from as a result of an increased rate of proteolytic degradation. In transient synovitis, the source of proteolytic activity may be chondrocytes activated by factors released by synovial cells. The release of joint proteoglycan may cause a temporary increase in deformability of the hip cartilage of the child that could be an important pathogenetic mechanism in some of the sequelae of these diseases.</p>}}, author = {{Lohmander, Stefan and Wingstrand, H. and Heinegard, D.}}, issn = {{0736-0266}}, keywords = {{child; hip; Transient synovitis}}, language = {{eng}}, number = {{3}}, pages = {{420--424}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Journal of Orthopaedic Research}}, title = {{Transient synovitis of the hip in the child : Increased levels of proteoglycan fragments in joint fluid}}, volume = {{6}}, year = {{1988}}, }