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Discovery of Teneurins

Baumgartner, Stefan LU and Wides, Ron (2019) In Frontiers in Neuroscience 13. p.1-9
Abstract

Teneurins were first discovered and published in 1993 and 1994, in Drosophila melanogaster as Ten-a and Ten-m. They were initially described as cell surface proteins, and as pair-rule genes. Later, they proved to be type II transmembrane proteins, and not to be pair-rule genes. Ten-m might nonetheless have had an ancestral function in clock-based segmentation as a Ten-m oscillator. The turn of the millennium saw a watershed of vertebrate Teneurin discovery, which was soon complemented by Teneurin protein annotations from whole genome sequence publications. Teneurins encode proteins with essentially invariant domain order and size. The first years of Teneurin studies in many experimental systems led to key insights, and a unified... (More)

Teneurins were first discovered and published in 1993 and 1994, in Drosophila melanogaster as Ten-a and Ten-m. They were initially described as cell surface proteins, and as pair-rule genes. Later, they proved to be type II transmembrane proteins, and not to be pair-rule genes. Ten-m might nonetheless have had an ancestral function in clock-based segmentation as a Ten-m oscillator. The turn of the millennium saw a watershed of vertebrate Teneurin discovery, which was soon complemented by Teneurin protein annotations from whole genome sequence publications. Teneurins encode proteins with essentially invariant domain order and size. The first years of Teneurin studies in many experimental systems led to key insights, and a unified picture, of Teneurin proteins.

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publication status
published
subject
in
Frontiers in Neuroscience
volume
13
pages
1 - 9
publisher
Frontiers
ISSN
1662-4548
DOI
10.3389/fnins.2019.00230
language
English
LU publication?
yes
id
da551cff-3c76-44fd-8eef-4ebe8ea5ecb7
date added to LUP
2019-05-21 14:17:26
date last changed
2019-05-24 02:17:21
@article{da551cff-3c76-44fd-8eef-4ebe8ea5ecb7,
  abstract     = {<p>Teneurins were first discovered and published in 1993 and 1994, in Drosophila melanogaster as Ten-a and Ten-m. They were initially described as cell surface proteins, and as pair-rule genes. Later, they proved to be type II transmembrane proteins, and not to be pair-rule genes. Ten-m might nonetheless have had an ancestral function in clock-based segmentation as a Ten-m oscillator. The turn of the millennium saw a watershed of vertebrate Teneurin discovery, which was soon complemented by Teneurin protein annotations from whole genome sequence publications. Teneurins encode proteins with essentially invariant domain order and size. The first years of Teneurin studies in many experimental systems led to key insights, and a unified picture, of Teneurin proteins.</p>},
  articleno    = {230},
  author       = {Baumgartner, Stefan and Wides, Ron},
  issn         = {1662-4548},
  language     = {eng},
  pages        = {1--9},
  publisher    = {Frontiers},
  series       = {Frontiers in Neuroscience},
  title        = {Discovery of Teneurins},
  url          = {http://dx.doi.org/10.3389/fnins.2019.00230},
  volume       = {13},
  year         = {2019},
}