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Target finding of pain nerve fibers : neural growth mechanisms in the tooth pulp

Fried, Kaj ; Lillesaar, Christina ; Sime, Wondossen LU ; Kaukua, Nina and Patarroyo, Manuel (2007) In Physiology & Behavior 92(1-2). p.5-40
Abstract

The tooth pulp has a dense sensory innervation which, upon stimulation, conveys sensory signals perceived as pain. This innervation, which originates from the trigeminal ganglion, is established through a series of regulated steps during development, and represents an interesting example of tissue targeting by pain-specific nerves. We have investigated various potentially neurotrophic and neurorepulsive influences during this process. The dental papilla/pulp appears to secrete neurite growth inhibitory molecular factors at early stages, which prevent nerve fibers from entering the tissue at what appears to be inappropriate timepoints. Later, a shift from repulsive to attractive factors apparently takes place, and nerve fibers then enter... (More)

The tooth pulp has a dense sensory innervation which, upon stimulation, conveys sensory signals perceived as pain. This innervation, which originates from the trigeminal ganglion, is established through a series of regulated steps during development, and represents an interesting example of tissue targeting by pain-specific nerves. We have investigated various potentially neurotrophic and neurorepulsive influences during this process. The dental papilla/pulp appears to secrete neurite growth inhibitory molecular factors at early stages, which prevent nerve fibers from entering the tissue at what appears to be inappropriate timepoints. Later, a shift from repulsive to attractive factors apparently takes place, and nerve fibers then enter the tooth. When nerve fibers have invaded the dental mesenchyme, a complicated interplay of secreted and membrane-bound factors probably directs the nerve terminals to appropriate sites. Laminin-8 (alpha4beta1gamma1, Lm-411), which is produced by pulpal cells, emerges as an important candidate molecule in this context. Insights into the interactions between the dental pulp nerve fibers and their environment may become important in the search for novel ways to ameliorate pain in the tooth, as well as at other sites.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Dental Pulp/innervation, Extracellular Matrix Proteins/physiology, Humans, Nerve Endings/growth & development, Nerve Growth Factors/metabolism, Neurites/physiology, Nociceptors/growth & development, Signal Transduction/physiology, Tooth/innervation
in
Physiology & Behavior
volume
92
issue
1-2
pages
5 - 40
publisher
Elsevier
external identifiers
  • scopus:34548542031
  • pmid:17585959
ISSN
0031-9384
DOI
10.1016/j.physbeh.2007.05.032
language
English
LU publication?
no
id
da7359a5-d4bc-4d26-8746-15081b4ca0e7
date added to LUP
2024-09-30 20:24:14
date last changed
2024-10-01 11:40:46
@article{da7359a5-d4bc-4d26-8746-15081b4ca0e7,
  abstract     = {{<p>The tooth pulp has a dense sensory innervation which, upon stimulation, conveys sensory signals perceived as pain. This innervation, which originates from the trigeminal ganglion, is established through a series of regulated steps during development, and represents an interesting example of tissue targeting by pain-specific nerves. We have investigated various potentially neurotrophic and neurorepulsive influences during this process. The dental papilla/pulp appears to secrete neurite growth inhibitory molecular factors at early stages, which prevent nerve fibers from entering the tissue at what appears to be inappropriate timepoints. Later, a shift from repulsive to attractive factors apparently takes place, and nerve fibers then enter the tooth. When nerve fibers have invaded the dental mesenchyme, a complicated interplay of secreted and membrane-bound factors probably directs the nerve terminals to appropriate sites. Laminin-8 (alpha4beta1gamma1, Lm-411), which is produced by pulpal cells, emerges as an important candidate molecule in this context. Insights into the interactions between the dental pulp nerve fibers and their environment may become important in the search for novel ways to ameliorate pain in the tooth, as well as at other sites.</p>}},
  author       = {{Fried, Kaj and Lillesaar, Christina and Sime, Wondossen and Kaukua, Nina and Patarroyo, Manuel}},
  issn         = {{0031-9384}},
  keywords     = {{Animals; Dental Pulp/innervation; Extracellular Matrix Proteins/physiology; Humans; Nerve Endings/growth & development; Nerve Growth Factors/metabolism; Neurites/physiology; Nociceptors/growth & development; Signal Transduction/physiology; Tooth/innervation}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{1-2}},
  pages        = {{5--40}},
  publisher    = {{Elsevier}},
  series       = {{Physiology & Behavior}},
  title        = {{Target finding of pain nerve fibers : neural growth mechanisms in the tooth pulp}},
  url          = {{http://dx.doi.org/10.1016/j.physbeh.2007.05.032}},
  doi          = {{10.1016/j.physbeh.2007.05.032}},
  volume       = {{92}},
  year         = {{2007}},
}