Target finding of pain nerve fibers : neural growth mechanisms in the tooth pulp
(2007) In Physiology & Behavior 92(1-2). p.5-40- Abstract
The tooth pulp has a dense sensory innervation which, upon stimulation, conveys sensory signals perceived as pain. This innervation, which originates from the trigeminal ganglion, is established through a series of regulated steps during development, and represents an interesting example of tissue targeting by pain-specific nerves. We have investigated various potentially neurotrophic and neurorepulsive influences during this process. The dental papilla/pulp appears to secrete neurite growth inhibitory molecular factors at early stages, which prevent nerve fibers from entering the tissue at what appears to be inappropriate timepoints. Later, a shift from repulsive to attractive factors apparently takes place, and nerve fibers then enter... (More)
The tooth pulp has a dense sensory innervation which, upon stimulation, conveys sensory signals perceived as pain. This innervation, which originates from the trigeminal ganglion, is established through a series of regulated steps during development, and represents an interesting example of tissue targeting by pain-specific nerves. We have investigated various potentially neurotrophic and neurorepulsive influences during this process. The dental papilla/pulp appears to secrete neurite growth inhibitory molecular factors at early stages, which prevent nerve fibers from entering the tissue at what appears to be inappropriate timepoints. Later, a shift from repulsive to attractive factors apparently takes place, and nerve fibers then enter the tooth. When nerve fibers have invaded the dental mesenchyme, a complicated interplay of secreted and membrane-bound factors probably directs the nerve terminals to appropriate sites. Laminin-8 (alpha4beta1gamma1, Lm-411), which is produced by pulpal cells, emerges as an important candidate molecule in this context. Insights into the interactions between the dental pulp nerve fibers and their environment may become important in the search for novel ways to ameliorate pain in the tooth, as well as at other sites.
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- author
- Fried, Kaj ; Lillesaar, Christina ; Sime, Wondossen LU ; Kaukua, Nina and Patarroyo, Manuel
- publishing date
- 2007-09-10
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Dental Pulp/innervation, Extracellular Matrix Proteins/physiology, Humans, Nerve Endings/growth & development, Nerve Growth Factors/metabolism, Neurites/physiology, Nociceptors/growth & development, Signal Transduction/physiology, Tooth/innervation
- in
- Physiology & Behavior
- volume
- 92
- issue
- 1-2
- pages
- 5 - 40
- publisher
- Elsevier
- external identifiers
-
- pmid:17585959
- scopus:34548542031
- ISSN
- 0031-9384
- DOI
- 10.1016/j.physbeh.2007.05.032
- language
- English
- LU publication?
- no
- id
- da7359a5-d4bc-4d26-8746-15081b4ca0e7
- date added to LUP
- 2024-09-30 20:24:14
- date last changed
- 2024-10-15 07:47:02
@article{da7359a5-d4bc-4d26-8746-15081b4ca0e7,
abstract = {{<p>The tooth pulp has a dense sensory innervation which, upon stimulation, conveys sensory signals perceived as pain. This innervation, which originates from the trigeminal ganglion, is established through a series of regulated steps during development, and represents an interesting example of tissue targeting by pain-specific nerves. We have investigated various potentially neurotrophic and neurorepulsive influences during this process. The dental papilla/pulp appears to secrete neurite growth inhibitory molecular factors at early stages, which prevent nerve fibers from entering the tissue at what appears to be inappropriate timepoints. Later, a shift from repulsive to attractive factors apparently takes place, and nerve fibers then enter the tooth. When nerve fibers have invaded the dental mesenchyme, a complicated interplay of secreted and membrane-bound factors probably directs the nerve terminals to appropriate sites. Laminin-8 (alpha4beta1gamma1, Lm-411), which is produced by pulpal cells, emerges as an important candidate molecule in this context. Insights into the interactions between the dental pulp nerve fibers and their environment may become important in the search for novel ways to ameliorate pain in the tooth, as well as at other sites.</p>}},
author = {{Fried, Kaj and Lillesaar, Christina and Sime, Wondossen and Kaukua, Nina and Patarroyo, Manuel}},
issn = {{0031-9384}},
keywords = {{Animals; Dental Pulp/innervation; Extracellular Matrix Proteins/physiology; Humans; Nerve Endings/growth & development; Nerve Growth Factors/metabolism; Neurites/physiology; Nociceptors/growth & development; Signal Transduction/physiology; Tooth/innervation}},
language = {{eng}},
month = {{09}},
number = {{1-2}},
pages = {{5--40}},
publisher = {{Elsevier}},
series = {{Physiology & Behavior}},
title = {{Target finding of pain nerve fibers : neural growth mechanisms in the tooth pulp}},
url = {{http://dx.doi.org/10.1016/j.physbeh.2007.05.032}},
doi = {{10.1016/j.physbeh.2007.05.032}},
volume = {{92}},
year = {{2007}},
}