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Association of IRS1 genetic variants with glucose control and insulin resistance in type 2 diabetic patients from Bosnia and Herzegovina

Mahmutovic, Lejla; Bego, Tamer; Sterner, Maria LU ; Gremsperger, Gabriella LU ; Ahlqvist, Emma LU ; Velija Asimi, Zelija; Prnjavorac, Besim; Hamad, Nour; Causevic, Adlija and Groop, Leif LU , et al. (2019) In Drug Metabolism and Personalized Therapy
Abstract


Previous studies reported conflicting results regarding association of insulin receptor substrate 1 (IRS1) gene variation with type 2 diabetes (T2D) and insulin resistance (IR) in different ethnic groups. We examined the association of rs7578326, rs2943641, and rs4675095 in the IRS1 gene with T2D and related traits in a population from Bosnia and Herzegovina, which is one of the European countries with the highest T2D prevalence of 12.5%. Our study included 390 T2D patients and 252 control subjects. Biochemical parameters, including fasting glucose (FG), fasting insulin (FI), homeostasis model assessment insulin resistance index (HOMA-IR), and HbA ... (More)


Previous studies reported conflicting results regarding association of insulin receptor substrate 1 (IRS1) gene variation with type 2 diabetes (T2D) and insulin resistance (IR) in different ethnic groups. We examined the association of rs7578326, rs2943641, and rs4675095 in the IRS1 gene with T2D and related traits in a population from Bosnia and Herzegovina, which is one of the European countries with the highest T2D prevalence of 12.5%. Our study included 390 T2D patients and 252 control subjects. Biochemical parameters, including fasting glucose (FG), fasting insulin (FI), homeostasis model assessment insulin resistance index (HOMA-IR), and HbA
1c
were measured in all participants. Genotyping analysis was performed by Mass Array Sequenom iPlex platform. Our results demonstrated that rs7578326 and rs4675095 variants were associated with increased FG levels. The rs7578326 was also associated with higher FI, HOMA-IR (B = 0.08, 95% CI [0.01, 0.15], p
add
= 0.025; B = 0.079, 95% CI [0.006, 0.150], p
add
= 0.033, respectively) in T2D, and with HbA
1c
(B = 0.034, 95% CI [0.003, 0.065], p
dom
= 0.035) in non-drug-treated T2D. In contrast, rs2943641 C allele was associated with lower FG levels in control subjects (B = -0.17, 95% CI [-0.03, -0.002], p
add
= 0.030) and HbA
1c
(B = 0.03, 95% CI [0.002, 0.06], p
dom
= 0.040) in non-drug-treated T2D. We report the association between common variants in IRS1 gene with insulin resistance, glucose, and HbA
1c
levels in Bosnia and Herzegovina's population.

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organization
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Contribution to journal
publication status
epub
subject
keywords
fasting glucose, HbA, HOMA-IR, insulin resistance, IRS1, single nucleotide polymorphism
in
Drug Metabolism and Personalized Therapy
publisher
De Gruyter
external identifiers
  • scopus:85063496696
ISSN
2363-8907
DOI
10.1515/dmpt-2018-0031
language
English
LU publication?
yes
id
daf5c5d4-53c9-43f9-97c9-7b830a0cb7b7
date added to LUP
2019-04-10 13:31:09
date last changed
2019-04-30 04:11:08
@article{daf5c5d4-53c9-43f9-97c9-7b830a0cb7b7,
  abstract     = {<p><br>
                                                         Previous studies reported conflicting results regarding association of insulin receptor substrate 1 (IRS1) gene variation with type 2 diabetes (T2D) and insulin resistance (IR) in different ethnic groups. We examined the association of rs7578326, rs2943641, and rs4675095 in the IRS1 gene with T2D and related traits in a population from Bosnia and Herzegovina, which is one of the European countries with the highest T2D prevalence of 12.5%. Our study included 390 T2D patients and 252 control subjects. Biochemical parameters, including fasting glucose (FG), fasting insulin (FI), homeostasis model assessment insulin resistance index (HOMA-IR), and HbA                             <br>
                            <sub>1c</sub><br>
                                                          were measured in all participants. Genotyping analysis was performed by Mass Array Sequenom iPlex platform. Our results demonstrated that rs7578326 and rs4675095 variants were associated with increased FG levels. The rs7578326 was also associated with higher FI, HOMA-IR (B = 0.08, 95% CI [0.01, 0.15], p                             <br>
                            <sub>add</sub><br>
                                                          = 0.025; B = 0.079, 95% CI [0.006, 0.150], p                             <br>
                            <sub>add</sub><br>
                                                          = 0.033, respectively) in T2D, and with HbA                             <br>
                            <sub>1c</sub><br>
                                                          (B = 0.034, 95% CI [0.003, 0.065], p                             <br>
                            <sub>dom</sub><br>
                                                          = 0.035) in non-drug-treated T2D. In contrast, rs2943641 C allele was associated with lower FG levels in control subjects (B = -0.17, 95% CI [-0.03, -0.002], p                             <br>
                            <sub>add</sub><br>
                                                          = 0.030) and HbA                             <br>
                            <sub>1c</sub><br>
                                                          (B = 0.03, 95% CI [0.002, 0.06], p                             <br>
                            <sub>dom</sub><br>
                                                          = 0.040) in non-drug-treated T2D. We report the association between common variants in IRS1 gene with insulin resistance, glucose, and HbA                             <br>
                            <sub>1c</sub><br>
                                                          levels in Bosnia and Herzegovina's population.                         <br>
                        </p>},
  author       = {Mahmutovic, Lejla and Bego, Tamer and Sterner, Maria and Gremsperger, Gabriella and Ahlqvist, Emma and Velija Asimi, Zelija and Prnjavorac, Besim and Hamad, Nour and Causevic, Adlija and Groop, Leif and Semiz, Sabina},
  issn         = {2363-8907},
  keyword      = {fasting glucose,HbA,HOMA-IR,insulin resistance,IRS1,single nucleotide polymorphism},
  language     = {eng},
  publisher    = {De Gruyter},
  series       = {Drug Metabolism and Personalized Therapy},
  title        = {Association of IRS1 genetic variants with glucose control and insulin resistance in type 2 diabetic patients from Bosnia and Herzegovina},
  url          = {http://dx.doi.org/10.1515/dmpt-2018-0031},
  year         = {2019},
}