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The outcome of 9 years of consecutive patch testing with 4,4'-diaminodiphenylmethane and 4,4'-diphenylmethane diisocyanate.

Engfeldt, Malin LU ; Goossens, An ; Isaksson, Marléne LU ; Zimerson, Erik LU and Bruze, Magnus LU (2013) In Contact Dermatitis 68(2). p.98-102
Abstract
Background:

Two outbreaks of allergic contact dermatitis caused by isocyanates at two companies in southern Sweden initiated a research project focusing on contact allergy to isocyanates. Within the project, there was an interest in determining how often contact allergy to the most common isocyanate, diphenylmethane-4,4'-diisocyanate (4,4'-MDI), occurred.



Objectives:

To determine and compare the occurrence of contact allergy to 4,4'-MDI, its corresponding amine 4,4'-diaminodiphenylmethane (4,4'-MDA), and polymeric diphenylmethane diisocyanate (PMDI) in a Swedish and a Belgian study population. Patients and method. The study population consisted of 6190 consecutively patch tested dermatitis patients:... (More)
Background:

Two outbreaks of allergic contact dermatitis caused by isocyanates at two companies in southern Sweden initiated a research project focusing on contact allergy to isocyanates. Within the project, there was an interest in determining how often contact allergy to the most common isocyanate, diphenylmethane-4,4'-diisocyanate (4,4'-MDI), occurred.



Objectives:

To determine and compare the occurrence of contact allergy to 4,4'-MDI, its corresponding amine 4,4'-diaminodiphenylmethane (4,4'-MDA), and polymeric diphenylmethane diisocyanate (PMDI) in a Swedish and a Belgian study population. Patients and method. The study population consisted of 6190 consecutively patch tested dermatitis patients: 5690 patients from Malmö, Sweden, and 500 patients from Leuven, Belgium. Patch test results were analysed and compared. Results. None of the Belgian patients reacted positively to 4,4'-MDI, but 5 Swedish patients did. Contact allergy to 4,4'-MDA was more common in the Belgian patients than in the Swedish patients: 3.6% and 0.9%, respectively. This could possibly be explained by the fact that the prevalence of p-phenylenediamine allergy was higher in the Belgian population.



Conclusions:

The prevalence of contact allergy to 4,4'-MDI, 4,4'-MDA and PMDI is not high enough to justify their inclusion in any baseline series. Isocyanate allergic individuals should be detected by aimed testing with isocyanate series and work materials. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
4, contact allergy, 4'-diaminodiphenylmethane, diphenylmethane-4, 4'-diisocyanate, 4'-MDA, 4'-MDI
in
Contact Dermatitis
volume
68
issue
2
pages
98 - 102
publisher
Wiley-Blackwell
external identifiers
  • wos:000313122000005
  • pmid:22928981
  • scopus:84872085657
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2012.02158.x
language
English
LU publication?
yes
id
db015567-3e95-462a-a04f-9cfa972e05d2 (old id 3047053)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22928981?dopt=Abstract
date added to LUP
2016-04-01 10:02:27
date last changed
2022-08-05 02:42:08
@article{db015567-3e95-462a-a04f-9cfa972e05d2,
  abstract     = {{Background:<br/><br>
Two outbreaks of allergic contact dermatitis caused by isocyanates at two companies in southern Sweden initiated a research project focusing on contact allergy to isocyanates. Within the project, there was an interest in determining how often contact allergy to the most common isocyanate, diphenylmethane-4,4'-diisocyanate (4,4'-MDI), occurred. <br/><br>
<br/><br>
Objectives:<br/><br>
To determine and compare the occurrence of contact allergy to 4,4'-MDI, its corresponding amine 4,4'-diaminodiphenylmethane (4,4'-MDA), and polymeric diphenylmethane diisocyanate (PMDI) in a Swedish and a Belgian study population. Patients and method. The study population consisted of 6190 consecutively patch tested dermatitis patients: 5690 patients from Malmö, Sweden, and 500 patients from Leuven, Belgium. Patch test results were analysed and compared. Results. None of the Belgian patients reacted positively to 4,4'-MDI, but 5 Swedish patients did. Contact allergy to 4,4'-MDA was more common in the Belgian patients than in the Swedish patients: 3.6% and 0.9%, respectively. This could possibly be explained by the fact that the prevalence of p-phenylenediamine allergy was higher in the Belgian population. <br/><br>
<br/><br>
Conclusions:<br/><br>
The prevalence of contact allergy to 4,4'-MDI, 4,4'-MDA and PMDI is not high enough to justify their inclusion in any baseline series. Isocyanate allergic individuals should be detected by aimed testing with isocyanate series and work materials.}},
  author       = {{Engfeldt, Malin and Goossens, An and Isaksson, Marléne and Zimerson, Erik and Bruze, Magnus}},
  issn         = {{0105-1873}},
  keywords     = {{4; contact allergy; 4'-diaminodiphenylmethane; diphenylmethane-4; 4'-diisocyanate; 4'-MDA; 4'-MDI}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{98--102}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{The outcome of 9 years of consecutive patch testing with 4,4'-diaminodiphenylmethane and 4,4'-diphenylmethane diisocyanate.}},
  url          = {{http://dx.doi.org/10.1111/j.1600-0536.2012.02158.x}},
  doi          = {{10.1111/j.1600-0536.2012.02158.x}},
  volume       = {{68}},
  year         = {{2013}},
}