Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis : A longitudinal Swedish study
(2021) In Rheumatology (Bulgaria) 60(9). p.4085-4093- Abstract
Objectives: Antibodies against anti-CD74 are related to axial spondyloarthritis (axSpA). The objectives were (i) to study IgA anti-CD74 in radiographic (r)-axSpA patients in the Backbone cohort and to calculate the sensitivity and specificity of anti-CD74, (ii) to study the fluctuation of IgA anti-CD74 levels in prospectively collected samples, and (iii) to explore the relation between IgA anti-CD74 and radiographic spinal changes. Methods: IgA anti-CD74 was analysed by ELISA in 155 patients with r-axSpA and age-and sex-matched controls. BASDAI, ASDAS, BASFI and BASMI were assessed and spinal radiographs were scored for r-axSpA-related changes with mSASSS. Previously donated samples, before inclusion in the Backbone study, were... (More)
Objectives: Antibodies against anti-CD74 are related to axial spondyloarthritis (axSpA). The objectives were (i) to study IgA anti-CD74 in radiographic (r)-axSpA patients in the Backbone cohort and to calculate the sensitivity and specificity of anti-CD74, (ii) to study the fluctuation of IgA anti-CD74 levels in prospectively collected samples, and (iii) to explore the relation between IgA anti-CD74 and radiographic spinal changes. Methods: IgA anti-CD74 was analysed by ELISA in 155 patients with r-axSpA and age-and sex-matched controls. BASDAI, ASDAS, BASFI and BASMI were assessed and spinal radiographs were scored for r-axSpA-related changes with mSASSS. Previously donated samples, before inclusion in the Backbone study, were identified in the Medical Biobank of Northern Sweden. Results: A total of 155 patients comprising 69% men and 31% women, age [mean (s.d.)] 55.5 (11.4) years and 152 (98.1%) HLA-B27 positive, were included. The plasma level of IgA anti-CD74 was significantly higher in the patients [median (interquartile range), 12.9 (7.9-17.9) U/ml] compared with controls [10.9 (7.2-14.6) U/ml, P = 0.003]. IgA anti-CD74 was above the cut-off level of 20 U/ml in 36/155 (23.2%) patients and in 15/151 (9.9%) controls (P = 0.002). Multivariable logistic regression analyses revealed ≥1 syndesmophyte associated with IgA anti-CD74 (odds ratio 5.64; 95% CI: 1.02, 35.58; P = 0.048) adjusted for hsCRP, smoking, BMI, sex and age. No distinct pattern of IgA anti-CD74 over time was revealed. Conclusion: Plasma levels of IgA anti-CD74 were increased in r-axSpA and independently associated with radiographic spinal changes, which suggests that IgA anti-CD74 could play a role in the pathogenies of r-axSpA.
(Less)
- author
- Do, Lan ; Granåsen, Gabriel ; Hellman, Urban ; Lejon, Kristina ; Geijer, Mats LU ; Baraliakos, Xenofon ; Witte, Torsten and Forsblad-D'elia, Helena
- organization
- publishing date
- 2021-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- IgA anti-CD74, Outcomes research, Radiographic axial spondyloarthritis ankylosing spondylitis
- in
- Rheumatology (Bulgaria)
- volume
- 60
- issue
- 9
- pages
- 9 pages
- publisher
- Meditsiinski Unversitet-Sofia
- external identifiers
-
- scopus:85114422689
- pmid:33369649
- ISSN
- 1310-0505
- DOI
- 10.1093/rheumatology/keaa882
- language
- English
- LU publication?
- yes
- id
- db01ea10-de13-49e7-b1a9-9e65acff19b5
- date added to LUP
- 2022-02-22 13:53:09
- date last changed
- 2024-06-27 12:25:14
@article{db01ea10-de13-49e7-b1a9-9e65acff19b5,
abstract = {{<p>Objectives: Antibodies against anti-CD74 are related to axial spondyloarthritis (axSpA). The objectives were (i) to study IgA anti-CD74 in radiographic (r)-axSpA patients in the Backbone cohort and to calculate the sensitivity and specificity of anti-CD74, (ii) to study the fluctuation of IgA anti-CD74 levels in prospectively collected samples, and (iii) to explore the relation between IgA anti-CD74 and radiographic spinal changes. Methods: IgA anti-CD74 was analysed by ELISA in 155 patients with r-axSpA and age-and sex-matched controls. BASDAI, ASDAS, BASFI and BASMI were assessed and spinal radiographs were scored for r-axSpA-related changes with mSASSS. Previously donated samples, before inclusion in the Backbone study, were identified in the Medical Biobank of Northern Sweden. Results: A total of 155 patients comprising 69% men and 31% women, age [mean (s.d.)] 55.5 (11.4) years and 152 (98.1%) HLA-B27 positive, were included. The plasma level of IgA anti-CD74 was significantly higher in the patients [median (interquartile range), 12.9 (7.9-17.9) U/ml] compared with controls [10.9 (7.2-14.6) U/ml, P = 0.003]. IgA anti-CD74 was above the cut-off level of 20 U/ml in 36/155 (23.2%) patients and in 15/151 (9.9%) controls (P = 0.002). Multivariable logistic regression analyses revealed ≥1 syndesmophyte associated with IgA anti-CD74 (odds ratio 5.64; 95% CI: 1.02, 35.58; P = 0.048) adjusted for hsCRP, smoking, BMI, sex and age. No distinct pattern of IgA anti-CD74 over time was revealed. Conclusion: Plasma levels of IgA anti-CD74 were increased in r-axSpA and independently associated with radiographic spinal changes, which suggests that IgA anti-CD74 could play a role in the pathogenies of r-axSpA. </p>}},
author = {{Do, Lan and Granåsen, Gabriel and Hellman, Urban and Lejon, Kristina and Geijer, Mats and Baraliakos, Xenofon and Witte, Torsten and Forsblad-D'elia, Helena}},
issn = {{1310-0505}},
keywords = {{IgA anti-CD74; Outcomes research; Radiographic axial spondyloarthritis ankylosing spondylitis}},
language = {{eng}},
month = {{09}},
number = {{9}},
pages = {{4085--4093}},
publisher = {{Meditsiinski Unversitet-Sofia}},
series = {{Rheumatology (Bulgaria)}},
title = {{Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis : A longitudinal Swedish study}},
url = {{http://dx.doi.org/10.1093/rheumatology/keaa882}},
doi = {{10.1093/rheumatology/keaa882}},
volume = {{60}},
year = {{2021}},
}