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Lower bone turnover and relative bone deficits in men with metabolic syndrome : a matter of insulin sensitivity? The European Male Ageing Study

Laurent, M. R. ; Cook, M. J. ; Gielen, E. ; Ward, K. A. ; Antonio, L. ; Adams, J. E. ; Decallonne, B. ; Bartfai, G. ; Casanueva, F. F. and Forti, G. , et al. (2016) In Osteoporosis International 27(11). p.3227-3237
Abstract

Summary: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. Introduction: Metabolic syndrome (MetS) has been associated with lower bone turnover and relative bone mass or strength deficits (i.e. not proportionate to body mass index, BMI), but the relative contributions of MetS components related to insulin sensitivity or obesity to male bone health remain unclear. Methods: We determined cross-sectional associations of... (More)

Summary: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. Introduction: Metabolic syndrome (MetS) has been associated with lower bone turnover and relative bone mass or strength deficits (i.e. not proportionate to body mass index, BMI), but the relative contributions of MetS components related to insulin sensitivity or obesity to male bone health remain unclear. Methods: We determined cross-sectional associations of MetS, its components and insulin sensitivity (by homeostatic model assessment-insulin sensitivity (HOMA-S)) using linear regression models adjusted for age, centre, smoking, alcohol, and BMI. Bone turnover markers and heel broadband ultrasound attenuation (BUA) were measured in 3129 men aged 40–79. Two centres measured total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD, n = 527) and performed radius peripheral quantitative computed tomography (pQCT, n = 595). Results: MetS was present in 975 men (31.2 %). Men with MetS had lower β C-terminal cross-linked telopeptide (β-CTX), N-terminal propeptide of type I procollagen (PINP) and osteocalcin (P <0.0001) and higher total hip, femoral neck, and lumbar spine aBMD (P ≤ 0.03). Among MetS components, only hypertriglyceridaemia and hyperglycaemia were independently associated with PINP and β-CTX. Hyperglycaemia was negatively associated with BUA, hypertriglyceridaemia with hip aBMD and radius cross-sectional area (CSA) and stress–strain index. HOMA-S was similarly associated with PINP and β-CTX, BUA, and radius CSA in BMI-adjusted models. Conclusions: Men with MetS have higher aBMD in association with their greater body mass, while their lower bone turnover and relative deficits in heel BUA and radius CSA are mainly related to correlates of insulin sensitivity. Our findings support the hypothesis that underlying metabolic complications may be involved in the bone’s failure to adapt to increasing bodily loads in men with MetS.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bone mineral density, Bone turnover, Male, Metabolic syndrome, Obesity, Peripheral quantitative computed tomography
in
Osteoporosis International
volume
27
issue
11
pages
3227 - 3237
publisher
Springer
external identifiers
  • pmid:27273111
  • wos:000388954600012
  • scopus:84976309693
ISSN
0937-941X
DOI
10.1007/s00198-016-3656-x
language
English
LU publication?
yes
id
db0d9f26-0ff3-4a36-a101-8449e8c00238
date added to LUP
2016-07-20 11:05:56
date last changed
2025-01-12 09:08:08
@article{db0d9f26-0ff3-4a36-a101-8449e8c00238,
  abstract     = {{<p>Summary: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. Introduction: Metabolic syndrome (MetS) has been associated with lower bone turnover and relative bone mass or strength deficits (i.e. not proportionate to body mass index, BMI), but the relative contributions of MetS components related to insulin sensitivity or obesity to male bone health remain unclear. Methods: We determined cross-sectional associations of MetS, its components and insulin sensitivity (by homeostatic model assessment-insulin sensitivity (HOMA-S)) using linear regression models adjusted for age, centre, smoking, alcohol, and BMI. Bone turnover markers and heel broadband ultrasound attenuation (BUA) were measured in 3129 men aged 40–79. Two centres measured total hip, femoral neck, and lumbar spine areal bone mineral density (<sub>a</sub>BMD, n = 527) and performed radius peripheral quantitative computed tomography (pQCT, n = 595). Results: MetS was present in 975 men (31.2 %). Men with MetS had lower β C-terminal cross-linked telopeptide (β-CTX), N-terminal propeptide of type I procollagen (PINP) and osteocalcin (P &lt;0.0001) and higher total hip, femoral neck, and lumbar spine <sub>a</sub>BMD (P ≤ 0.03). Among MetS components, only hypertriglyceridaemia and hyperglycaemia were independently associated with PINP and β-CTX. Hyperglycaemia was negatively associated with BUA, hypertriglyceridaemia with hip <sub>a</sub>BMD and radius cross-sectional area (CSA) and stress–strain index. HOMA-S was similarly associated with PINP and β-CTX, BUA, and radius CSA in BMI-adjusted models. Conclusions: Men with MetS have higher <sub>a</sub>BMD in association with their greater body mass, while their lower bone turnover and relative deficits in heel BUA and radius CSA are mainly related to correlates of insulin sensitivity. Our findings support the hypothesis that underlying metabolic complications may be involved in the bone’s failure to adapt to increasing bodily loads in men with MetS.</p>}},
  author       = {{Laurent, M. R. and Cook, M. J. and Gielen, E. and Ward, K. A. and Antonio, L. and Adams, J. E. and Decallonne, B. and Bartfai, G. and Casanueva, F. F. and Forti, G. and Giwercman, A. and Huhtaniemi, I. T. and Kula, K. and Lean, M. E J and Lee, D. M. and Pendleton, N. and Punab, M. and Claessens, F. and Wu, F. C W and Vanderschueren, D. and Pye, S. R. and O’Neill, T. W. and Emas Group, Group}},
  issn         = {{0937-941X}},
  keywords     = {{Bone mineral density; Bone turnover; Male; Metabolic syndrome; Obesity; Peripheral quantitative computed tomography}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{3227--3237}},
  publisher    = {{Springer}},
  series       = {{Osteoporosis International}},
  title        = {{Lower bone turnover and relative bone deficits in men with metabolic syndrome : a matter of insulin sensitivity? The European Male Ageing Study}},
  url          = {{http://dx.doi.org/10.1007/s00198-016-3656-x}},
  doi          = {{10.1007/s00198-016-3656-x}},
  volume       = {{27}},
  year         = {{2016}},
}