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Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial.

Chapman, Kenneth R ; Burdon, Jonathan G W ; Piitulainen, Eeva LU ; Sandhaus, Robert A ; Seersholm, Niels ; Stocks, James M ; Stoel, Berend C ; Huang, Liping ; Yao, Zhenling and Edelman, Jonathan M , et al. (2015) In The Lancet 386(9991). p.360-368
Abstract
The efficacy of α1 proteinase inhibitor (A1PI) augmentation treatment for α1 antitrypsin deficiency has not been substantiated by a randomised, placebo-controlled trial. CT-measured lung density is a more sensitive measure of disease progression in α1 antitrypsin deficiency emphysema than spirometry is, so we aimed to assess the efficacy of augmentation treatment with this measure.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet
volume
386
issue
9991
pages
360 - 368
publisher
Elsevier
external identifiers
  • pmid:26026936
  • wos:000358448400025
  • scopus:84937969384
ISSN
1474-547X
DOI
10.1016/S0140-6736(15)60860-1
language
English
LU publication?
yes
id
db4f97f8-0b5b-4185-a1a6-245da19bbe27 (old id 7508712)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26026936?dopt=Abstract
date added to LUP
2016-04-01 09:51:06
date last changed
2022-04-27 07:44:59
@article{db4f97f8-0b5b-4185-a1a6-245da19bbe27,
  abstract     = {{The efficacy of α1 proteinase inhibitor (A1PI) augmentation treatment for α1 antitrypsin deficiency has not been substantiated by a randomised, placebo-controlled trial. CT-measured lung density is a more sensitive measure of disease progression in α1 antitrypsin deficiency emphysema than spirometry is, so we aimed to assess the efficacy of augmentation treatment with this measure.}},
  author       = {{Chapman, Kenneth R and Burdon, Jonathan G W and Piitulainen, Eeva and Sandhaus, Robert A and Seersholm, Niels and Stocks, James M and Stoel, Berend C and Huang, Liping and Yao, Zhenling and Edelman, Jonathan M and McElvaney, Noel G}},
  issn         = {{1474-547X}},
  language     = {{eng}},
  number       = {{9991}},
  pages        = {{360--368}},
  publisher    = {{Elsevier}},
  series       = {{The Lancet}},
  title        = {{Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial.}},
  url          = {{http://dx.doi.org/10.1016/S0140-6736(15)60860-1}},
  doi          = {{10.1016/S0140-6736(15)60860-1}},
  volume       = {{386}},
  year         = {{2015}},
}