The impact of PRODIGE 7 on the current worldwide practice of CRS-HIPEC for colorectal peritoneal metastases : A web-based survey and 2021 statement by Peritoneal Surface Oncology Group International (PSOGI)
(2021) In European Journal of Surgical Oncology 47(11). p.2888-2892- Abstract
Introduction: The PRODIGE 7-trial investigated the additional value of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) to cytoreductive surgery (CRS) for patients with colorectal peritoneal metastases (CPM). The results of PRODIGE 7 were presented at the 2018 ASCO meeting showing that 30 min oxaliplatin-based HIPEC did not improve overall survival. The current study investigated the impact of PRODIGE 7 on the worldwide practice of CRS and HIPEC. Materials and methods: CRS-HIPEC experts from 19 countries were invited through the Peritoneal Surface Oncology Group International (PSOGI) to complete an online survey concerning the current CRS-HIPEC practice in their hospital and country, and were asked to appraise the effect of PRODIGE 7.... (More)
Introduction: The PRODIGE 7-trial investigated the additional value of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) to cytoreductive surgery (CRS) for patients with colorectal peritoneal metastases (CPM). The results of PRODIGE 7 were presented at the 2018 ASCO meeting showing that 30 min oxaliplatin-based HIPEC did not improve overall survival. The current study investigated the impact of PRODIGE 7 on the worldwide practice of CRS and HIPEC. Materials and methods: CRS-HIPEC experts from 19 countries were invited through the Peritoneal Surface Oncology Group International (PSOGI) to complete an online survey concerning the current CRS-HIPEC practice in their hospital and country, and were asked to appraise the effect of PRODIGE 7. Results: The survey was completed by 18/19 experts. Although their personal opinions of CRS-HIPEC were barely influenced by PRODIGE 7, they reported a substantial impact on daily practice. This included a switch towards Mitomycin-C based HIPEC-regimens and prolongation of HIPEC perfusion time, a reduction in the number of referrals from non-HIPEC centers, a reduction in national consensus, the removal of HIPEC from national guidelines, and a reduced reimbursement rate. Conclusion: The PRODIGE 7 has had a major impact on the practice of CRS-HIPEC for CPM worldwide. HIPEC remains an attractive option with potential for control and eradication of disease and further studies into the optimal HIPEC-regimen are urgently needed. Meanwhile, given the complexity of the treatment of patients with CPM, and the proven benefits of optimal CRS, referral of patients with potentially resectable CPM to expert centers is recommended whilst the precise role of HIPEC is further evaluated.
(Less)
- author
- publishing date
- 2021-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Colorectal peritoneal metastases, CRS-HIPEC, HIPEC, PRODIGE 7
- in
- European Journal of Surgical Oncology
- volume
- 47
- issue
- 11
- pages
- 2888 - 2892
- publisher
- Elsevier
- external identifiers
-
- pmid:34020808
- scopus:85106384899
- ISSN
- 0748-7983
- DOI
- 10.1016/j.ejso.2021.05.023
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2021
- id
- db53fcbe-87d5-4151-994b-b42ef045a3da
- date added to LUP
- 2022-03-31 12:41:03
- date last changed
- 2024-04-13 13:00:55
@article{db53fcbe-87d5-4151-994b-b42ef045a3da,
abstract = {{<p>Introduction: The PRODIGE 7-trial investigated the additional value of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) to cytoreductive surgery (CRS) for patients with colorectal peritoneal metastases (CPM). The results of PRODIGE 7 were presented at the 2018 ASCO meeting showing that 30 min oxaliplatin-based HIPEC did not improve overall survival. The current study investigated the impact of PRODIGE 7 on the worldwide practice of CRS and HIPEC. Materials and methods: CRS-HIPEC experts from 19 countries were invited through the Peritoneal Surface Oncology Group International (PSOGI) to complete an online survey concerning the current CRS-HIPEC practice in their hospital and country, and were asked to appraise the effect of PRODIGE 7. Results: The survey was completed by 18/19 experts. Although their personal opinions of CRS-HIPEC were barely influenced by PRODIGE 7, they reported a substantial impact on daily practice. This included a switch towards Mitomycin-C based HIPEC-regimens and prolongation of HIPEC perfusion time, a reduction in the number of referrals from non-HIPEC centers, a reduction in national consensus, the removal of HIPEC from national guidelines, and a reduced reimbursement rate. Conclusion: The PRODIGE 7 has had a major impact on the practice of CRS-HIPEC for CPM worldwide. HIPEC remains an attractive option with potential for control and eradication of disease and further studies into the optimal HIPEC-regimen are urgently needed. Meanwhile, given the complexity of the treatment of patients with CPM, and the proven benefits of optimal CRS, referral of patients with potentially resectable CPM to expert centers is recommended whilst the precise role of HIPEC is further evaluated.</p>}},
author = {{van de Vlasakker, Vincent C.J. and Lurvink, Robin J. and Cashin, Peter H. and Ceelen, Wim and Deraco, Marcello and Goéré, Diane and González-Moreno, Santiago and Lehmann, Kuno and Li, Yan and Moran, Brendan and Morris, David L. and Piso, Pompiliu and Quadros, Claudio A. and Rau, Beate and Somashekhar, S. P. and Sommariva, Antonio and van der Speeten, Kurt and Spiliotis, John and Sugarbaker, Paul H. and Teo, Melissa C.C. and Verwaal, Vic J. and Yonemura, Yutaka and Glehen, Olivier and de Hingh, Ignace H.J.T.}},
issn = {{0748-7983}},
keywords = {{Colorectal peritoneal metastases; CRS-HIPEC; HIPEC; PRODIGE 7}},
language = {{eng}},
number = {{11}},
pages = {{2888--2892}},
publisher = {{Elsevier}},
series = {{European Journal of Surgical Oncology}},
title = {{The impact of PRODIGE 7 on the current worldwide practice of CRS-HIPEC for colorectal peritoneal metastases : A web-based survey and 2021 statement by Peritoneal Surface Oncology Group International (PSOGI)}},
url = {{http://dx.doi.org/10.1016/j.ejso.2021.05.023}},
doi = {{10.1016/j.ejso.2021.05.023}},
volume = {{47}},
year = {{2021}},
}