Lupus anticoagulants in two children-bleeding due to nonphospholipid-dependent antiprothrombin antibodies.
(2012) In European Journal of Pediatrics 171(9). p.1383-1387- Abstract
- We describe two children with significant bleeding: one with multiple ecchymoses and the other with scrotal bleeding. In both patients, the activated partial thromboplastin time (APTT) was prolonged, with positivity for lupus anticoagulants (LA). However, the Owren prothrombin time (PT), usually insensitive for LA, was also prolonged. The presence of LA is associated with diverse clinical manifestations, with most patients being asymptomatic while others present venous or arterial thrombosis. Bleeding in conjunction with LA is rare and it is unusual to see prolongation of the Owren PT assay due to LA. An extended laboratory investigation of one of the patient's plasma revealed not only LA but also a specific nonphospholipid-dependent... (More)
- We describe two children with significant bleeding: one with multiple ecchymoses and the other with scrotal bleeding. In both patients, the activated partial thromboplastin time (APTT) was prolonged, with positivity for lupus anticoagulants (LA). However, the Owren prothrombin time (PT), usually insensitive for LA, was also prolonged. The presence of LA is associated with diverse clinical manifestations, with most patients being asymptomatic while others present venous or arterial thrombosis. Bleeding in conjunction with LA is rare and it is unusual to see prolongation of the Owren PT assay due to LA. An extended laboratory investigation of one of the patient's plasma revealed not only LA but also a specific nonphospholipid-dependent antiprothrombin antibody causing an acquired hypoprothrombinemia. Conclusion: It is likely that the low prothrombin activity and not the LA caused the bleeding. The bleeding signs and symptoms in both patients subsided when the PT was normalized, although the prolonged APTT and the LA remained. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2519162
- author
- Knobe, Karin LU ; Tedgård, Ulf LU ; Ek, Torben ; Sandström, Per-Erik and Hillarp, Andreas LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Pediatrics
- volume
- 171
- issue
- 9
- pages
- 1383 - 1387
- publisher
- Springer
- external identifiers
-
- wos:000307701100012
- pmid:22527568
- scopus:84865967827
- pmid:22527568
- ISSN
- 1432-1076
- DOI
- 10.1007/s00431-012-1737-1
- language
- English
- LU publication?
- yes
- id
- db5b630b-3603-4e75-b050-2e6feb8a386c (old id 2519162)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22527568?dopt=Abstract
- date added to LUP
- 2016-04-01 10:55:23
- date last changed
- 2022-01-26 03:45:55
@article{db5b630b-3603-4e75-b050-2e6feb8a386c, abstract = {{We describe two children with significant bleeding: one with multiple ecchymoses and the other with scrotal bleeding. In both patients, the activated partial thromboplastin time (APTT) was prolonged, with positivity for lupus anticoagulants (LA). However, the Owren prothrombin time (PT), usually insensitive for LA, was also prolonged. The presence of LA is associated with diverse clinical manifestations, with most patients being asymptomatic while others present venous or arterial thrombosis. Bleeding in conjunction with LA is rare and it is unusual to see prolongation of the Owren PT assay due to LA. An extended laboratory investigation of one of the patient's plasma revealed not only LA but also a specific nonphospholipid-dependent antiprothrombin antibody causing an acquired hypoprothrombinemia. Conclusion: It is likely that the low prothrombin activity and not the LA caused the bleeding. The bleeding signs and symptoms in both patients subsided when the PT was normalized, although the prolonged APTT and the LA remained.}}, author = {{Knobe, Karin and Tedgård, Ulf and Ek, Torben and Sandström, Per-Erik and Hillarp, Andreas}}, issn = {{1432-1076}}, language = {{eng}}, number = {{9}}, pages = {{1383--1387}}, publisher = {{Springer}}, series = {{European Journal of Pediatrics}}, title = {{Lupus anticoagulants in two children-bleeding due to nonphospholipid-dependent antiprothrombin antibodies.}}, url = {{https://lup.lub.lu.se/search/files/2239382/2596543.pdf}}, doi = {{10.1007/s00431-012-1737-1}}, volume = {{171}}, year = {{2012}}, }