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Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

Zhao, Wei; Rasheed, Asif; Tikkanen, Emmi; Lee, Jung-Jin ; Butterworth, Adam S.; Howson, Joanna M. M.; Orho-Melander, Marju LU and Melander, Olle LU (2017) In Nature Genetics 49(10). p.1450-1457
Abstract
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLADRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint T2D- CHD analysis identified eight variants-two of which are coding-where T2D and CHD associations appear to colocalize, including a new joint T2D-CHD association at the CCDC92 locus that also replicated for T2D. The variants associated with... (More)
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLADRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint T2D- CHD analysis identified eight variants-two of which are coding-where T2D and CHD associations appear to colocalize, including a new joint T2D-CHD association at the CCDC92 locus that also replicated for T2D. The variants associated with both outcomes implicate new pathways as well as targets of existing drugs, including icosapent ethyl and adipocyte fatty-acid-binding protein. © 2017 Nature America, Inc., part of Springer Nature. All rights reserved. (Less)
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keywords
fatty acid binding protein 4, icosapentaenoic acid ethyl ester, biological marker, HLA DRB5 antigen, Article, CCDC92 gene, controlled study, East Asian, European, gene, gene locus, genetic risk, genetic susceptibility, genetic variability, genetic variation, genome-wide association study, HLA DRB5 gene, human, ischemic heart disease, major clinical study, non insulin dependent diabetes mellitus, priority journal, single nucleotide polymorphism, South Asian, Asia, Asian continental ancestry group, Caucasian, comorbidity, comparative study, Coronary Disease, Diabetes Mellitus, Type 2, Europe, genetic predisposition, genetics, metabolic syndrome X, metabolism, missense mutation, molecularly targeted therapy, risk factor, Asian Continental Ancestry Group, Biomarkers, Comorbidity, European Continental Ancestry Group, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, HLA-DRB5 Chains, Humans, Metabolic Networks and Pathways, Metabolic Syndrome X, Molecular Targeted Therapy, Mutation, Missense, Polymorphism, Single Nucleotide, Risk Factors
in
Nature Genetics
volume
49
issue
10
pages
8 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85030173238
  • wos:000411855800008
ISSN
1546-1718
DOI
10.1038/ng.3943
language
English
LU publication?
yes
id
db6e83ee-0dbb-4341-94c7-b5e33b0f36ff
date added to LUP
2017-11-28 11:08:07
date last changed
2018-10-16 04:02:10
@article{db6e83ee-0dbb-4341-94c7-b5e33b0f36ff,
  abstract     = {To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLADRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint T2D- CHD analysis identified eight variants-two of which are coding-where T2D and CHD associations appear to colocalize, including a new joint T2D-CHD association at the CCDC92 locus that also replicated for T2D. The variants associated with both outcomes implicate new pathways as well as targets of existing drugs, including icosapent ethyl and adipocyte fatty-acid-binding protein. © 2017 Nature America, Inc., part of Springer Nature. All rights reserved.},
  author       = {Zhao, Wei and Rasheed, Asif and Tikkanen, Emmi and Lee, Jung-Jin  and Butterworth, Adam S. and Howson, Joanna M. M. and Orho-Melander, Marju and Melander, Olle},
  issn         = {1546-1718},
  keyword      = {fatty acid binding protein 4,icosapentaenoic acid ethyl ester,biological marker,HLA DRB5 antigen,Article,CCDC92 gene,controlled study,East Asian,European,gene,gene locus,genetic risk,genetic susceptibility,genetic variability,genetic variation,genome-wide association study,HLA DRB5 gene,human,ischemic heart disease,major clinical study,non insulin dependent diabetes mellitus,priority journal,single nucleotide polymorphism,South Asian,Asia,Asian continental ancestry group,Caucasian,comorbidity,comparative study,Coronary Disease,Diabetes Mellitus, Type 2,Europe,genetic predisposition,genetics,metabolic syndrome X,metabolism,missense mutation,molecularly targeted therapy,risk factor,Asian Continental Ancestry Group,Biomarkers,Comorbidity,European Continental Ancestry Group,Genetic Loci,Genetic Predisposition to Disease,Genome-Wide Association Study,HLA-DRB5 Chains,Humans,Metabolic Networks and Pathways,Metabolic Syndrome X,Molecular Targeted Therapy,Mutation, Missense,Polymorphism, Single Nucleotide,Risk Factors},
  language     = {eng},
  number       = {10},
  pages        = {1450--1457},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease},
  url          = {http://dx.doi.org/10.1038/ng.3943},
  volume       = {49},
  year         = {2017},
}