Advanced

Long-term variation in influenza A virus prevalence and subtype diversity in migratory mallards in northern Europe

Latorre-Margalef, Neus LU ; Tolf, Conny; Grosbois, Vladimir; Avril, Alexis; Bengtsson, Daniel LU ; Wille, Michelle; Osterhaus, Albert D. M. E.; Fouchier, Ron A. M.; Olsen, Björn and Waldenström, Jonas LU (2014) In Proceedings of the Royal Society B: Biological Sciences 281(1781).
Abstract

Data on long-term circulation of pathogens in wildlife populations are seldom collected, and hence understanding of spatial-temporal variation in prevalence and genotypes is limited. Here, we analysed a long-term surveillance series on influenza A virus (IAV) in mallards collected at an important migratory stopover site from 2002 to 2010, and characterized seasonal dynamics in virus prevalence and subtype diversity. Prevalence dynamics were influenced by year, but retained a common pattern for all years whereby prevalence was low in spring and summer, but increased in early autumn with a first peak in August, and a second more pronounced peak during October-November. A total of 74 haemagglutinin (HA)/neuraminidase (NA) combinations were... (More)

Data on long-term circulation of pathogens in wildlife populations are seldom collected, and hence understanding of spatial-temporal variation in prevalence and genotypes is limited. Here, we analysed a long-term surveillance series on influenza A virus (IAV) in mallards collected at an important migratory stopover site from 2002 to 2010, and characterized seasonal dynamics in virus prevalence and subtype diversity. Prevalence dynamics were influenced by year, but retained a common pattern for all years whereby prevalence was low in spring and summer, but increased in early autumn with a first peak in August, and a second more pronounced peak during October-November. A total of 74 haemagglutinin (HA)/neuraminidase (NA) combinations were isolated, including all NA and most HA (H1-H12) subtypes. The most common subtype combinations were H4N6, H1N1, H2N3, H5N2, H6N2 and H11N9, and showed a clear linkage between specific HA and NA subtypes. Furthermore, there was a temporal structuring of subtypes within seasons based on HA phylogenetic relatedness. Dissimilar HA subtypes tended to have different temporal occurrence within seasons, where the subtypes that dominated in early autumn were rare in late autumn, and vice versa. This suggests that build-up of herd immunity affected IAV dynamics in this system.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Disease dynamics, Diversity, Host-pathogen interactions, Influenza A virus, Mallards, Prevalence
in
Proceedings of the Royal Society B: Biological Sciences
volume
281
issue
1781
publisher
Royal Society
external identifiers
  • scopus:84896886284
ISSN
0962-8452
DOI
10.1098/rspb.2014.0098
language
English
LU publication?
no
id
db706a8c-fc4e-458f-8622-0f4f8ef7f459
date added to LUP
2017-04-11 14:01:25
date last changed
2017-09-10 05:17:49
@article{db706a8c-fc4e-458f-8622-0f4f8ef7f459,
  abstract     = {<p>Data on long-term circulation of pathogens in wildlife populations are seldom collected, and hence understanding of spatial-temporal variation in prevalence and genotypes is limited. Here, we analysed a long-term surveillance series on influenza A virus (IAV) in mallards collected at an important migratory stopover site from 2002 to 2010, and characterized seasonal dynamics in virus prevalence and subtype diversity. Prevalence dynamics were influenced by year, but retained a common pattern for all years whereby prevalence was low in spring and summer, but increased in early autumn with a first peak in August, and a second more pronounced peak during October-November. A total of 74 haemagglutinin (HA)/neuraminidase (NA) combinations were isolated, including all NA and most HA (H1-H12) subtypes. The most common subtype combinations were H4N6, H1N1, H2N3, H5N2, H6N2 and H11N9, and showed a clear linkage between specific HA and NA subtypes. Furthermore, there was a temporal structuring of subtypes within seasons based on HA phylogenetic relatedness. Dissimilar HA subtypes tended to have different temporal occurrence within seasons, where the subtypes that dominated in early autumn were rare in late autumn, and vice versa. This suggests that build-up of herd immunity affected IAV dynamics in this system.</p>},
  articleno    = {20140098},
  author       = {Latorre-Margalef, Neus and Tolf, Conny and Grosbois, Vladimir and Avril, Alexis and Bengtsson, Daniel and Wille, Michelle and Osterhaus, Albert D. M. E. and Fouchier, Ron A. M. and Olsen, Björn and Waldenström, Jonas},
  issn         = {0962-8452},
  keyword      = {Disease dynamics,Diversity,Host-pathogen interactions,Influenza A virus,Mallards,Prevalence},
  language     = {eng},
  month        = {02},
  number       = {1781},
  publisher    = {Royal Society},
  series       = {Proceedings of the Royal Society B: Biological Sciences},
  title        = {Long-term variation in influenza A virus prevalence and subtype diversity in migratory mallards in northern Europe},
  url          = {http://dx.doi.org/10.1098/rspb.2014.0098},
  volume       = {281},
  year         = {2014},
}