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Babesia divergens Shows Equal Predilection for Human ABO Blood Types in an In Vitro Erythrocyte Preference Assay.

Tijani, Muyideen K LU ; Danielsson, Lena LU ; Storry, Jill R LU ; Olsson, Martin L LU orcid and Persson, Kristina E M LU (2023) In Pathogens 12(6). p.1-10
Abstract


Babesia is spread to humans via ticks or blood transfusions. Severity of
Plasmodium falciparum malaria is strongly correlated to the ABO blood group of the patient.
Babesia divergens is an intraerythrocytic parasite with many similarities to malaria, but the impact of ABO on the susceptibility to and progression of the infection in humans is unknown. We have now cultured
B. divergens in human group A, B and O erythrocytes in vitro and measured rates of multiplication. The predilection for the different erythrocyte types was also determined using an in vitro erythrocyte preference assay when the parasites were grown in group A, B or O erythrocytes over time and then offered to invade differently stained... (More)


Babesia is spread to humans via ticks or blood transfusions. Severity of
Plasmodium falciparum malaria is strongly correlated to the ABO blood group of the patient.
Babesia divergens is an intraerythrocytic parasite with many similarities to malaria, but the impact of ABO on the susceptibility to and progression of the infection in humans is unknown. We have now cultured
B. divergens in human group A, B and O erythrocytes in vitro and measured rates of multiplication. The predilection for the different erythrocyte types was also determined using an in vitro erythrocyte preference assay when the parasites were grown in group A, B or O erythrocytes over time and then offered to invade differently stained erythrocytes of all the blood types at the same time. The results showed no difference in multiplication rates for the different blood types, and the parasite exhibited no obvious morphological differences in the different blood types. When cultured first in one blood type and then offered to grow in the others, the preference assay showed that there was no difference between the A, B or O blood groups. In conclusion, this indicates that individuals of the different ABO blood types are likely to be equally susceptible to
B. divergens infections.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pathogens
volume
12
issue
6
pages
1 - 10
publisher
MDPI AG
external identifiers
  • scopus:85163622369
  • pmid:37375493
ISSN
2076-0817
DOI
10.3390/pathogens12060803
language
English
LU publication?
yes
id
db7d5281-7b7b-4900-892b-24f322aabc2c
date added to LUP
2023-07-10 15:11:09
date last changed
2024-04-19 23:17:24
@article{db7d5281-7b7b-4900-892b-24f322aabc2c,
  abstract     = {{<p><br>
 Babesia is spread to humans via ticks or blood transfusions. Severity of <br>
 Plasmodium falciparum malaria is strongly correlated to the ABO blood group of the patient. <br>
 Babesia divergens is an intraerythrocytic parasite with many similarities to malaria, but the impact of ABO on the susceptibility to and progression of the infection in humans is unknown. We have now cultured <br>
 B. divergens in human group A, B and O erythrocytes in vitro and measured rates of multiplication. The predilection for the different erythrocyte types was also determined using an in vitro erythrocyte preference assay when the parasites were grown in group A, B or O erythrocytes over time and then offered to invade differently stained erythrocytes of all the blood types at the same time. The results showed no difference in multiplication rates for the different blood types, and the parasite exhibited no obvious morphological differences in the different blood types. When cultured first in one blood type and then offered to grow in the others, the preference assay showed that there was no difference between the A, B or O blood groups. In conclusion, this indicates that individuals of the different ABO blood types are likely to be equally susceptible to<br>
 B. divergens infections.<br>
 </p>}},
  author       = {{Tijani, Muyideen K and Danielsson, Lena and Storry, Jill R and Olsson, Martin L and Persson, Kristina E M}},
  issn         = {{2076-0817}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{6}},
  pages        = {{1--10}},
  publisher    = {{MDPI AG}},
  series       = {{Pathogens}},
  title        = {{Babesia divergens Shows Equal Predilection for Human ABO Blood Types in an In Vitro Erythrocyte Preference Assay.}},
  url          = {{http://dx.doi.org/10.3390/pathogens12060803}},
  doi          = {{10.3390/pathogens12060803}},
  volume       = {{12}},
  year         = {{2023}},
}