Endometriosis diagnosed by ultrasound is associated with lower live birth rates in women undergoing their first IVF/ICSI treatment
Alson, Sara LU
; Henic, Emir
LU
; Jokubkiene, Ligita
LU
and Sladkevicius, Povilas
LU
(2024)
In Fertility and Sterility
- Abstract
- Objective
To study the cumulative live birth rate (CLBR) after the first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment in women with or without deep-infiltrating endometriosis (DIE) and/or endometrioma diagnosed by transvaginal ultrasonography (TVUS), using the International Deep Endometriosis Analysis (IDEA) group definitions.
Design
Prospective observational cohort study at a university hospital.
Patients(s)
In total, 1,040 women with subfertility aged 25 to ≤39 years were undergoing their first IVF/ICSI treatment between January 2019 and October 2022. Of these, 234 (22.5%; 95% confidence interval [CI], 20.0–25.0) women were diagnosed with DIE and/or endometrioma at systematic TVUS... (More) - Objective
To study the cumulative live birth rate (CLBR) after the first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment in women with or without deep-infiltrating endometriosis (DIE) and/or endometrioma diagnosed by transvaginal ultrasonography (TVUS), using the International Deep Endometriosis Analysis (IDEA) group definitions.
Design
Prospective observational cohort study at a university hospital.
Patients(s)
In total, 1,040 women with subfertility aged 25 to ≤39 years were undergoing their first IVF/ICSI treatment between January 2019 and October 2022. Of these, 234 (22.5%; 95% confidence interval [CI], 20.0–25.0) women were diagnosed with DIE and/or endometrioma at systematic TVUS before starting their treatment.
Intervention(s)
All women underwent their first IVF or ICSI treatment. Fresh and/or frozen embryos from the first cycle were used until pregnancy was achieved or no embryos remained.
Main Outcome Measure(s)
Cumulative live birth rate after the first IVF/ICSI cycle in women with or without DIE and/or endometrioma.
Result(s)
The CLBR after the first IVF/ICSI treatment in the total cohort of women was 426/1,040 (41.0%; 95% CI, 38.0–44.0). Women with DIE and/or endometrioma had a lower CLBR (78/234, 33.3%; 95% CI, 27.3–39.4) than women without the disease (348/806, 43.2%; 95% CI, 39.8–46.6). The crude relative risk (RR) for cumulative live birth for women with DIE and/or endometrioma was 0.77; 95% CI, 0.63–0.94, and after adjustments were made for age, body mass index, s-antimüllerian hormone, stimulation protocol, and day for embryo transfer, the adjusted RR was 0.63; 95% CI, 0.48–0.82. There was no difference in the number of retrieved mature oocytes, fertilization rate, or good quality embryos between the 2 groups.
Conclusion
The presence of DIE and/or endometrioma diagnosed by TVUS lowers the chance of live birth in women undergoing their first IVF/ICSI treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/dbdc7208-9834-4806-a11f-a1c41b6bd433
- author
- Alson, Sara
LU
; Henic, Emir
LU
; Jokubkiene, Ligita
LU
and Sladkevicius, Povilas
LU
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- gynaecology, reproduction, ultrasound, infertility, IVF / ICSI, Endometriosis
- in
- Fertility and Sterility
- publisher
- Elsevier
- external identifiers
-
- pmid:38246403
- scopus:85187285602
- ISSN
- 1556-5653
- DOI
- 10.1016/j.fertnstert.2024.01.023
- project
- Deep infiltrating endometriosis (DIE) diagnosed by ultrasound in subfertile women - effect on Anti-Müllerian Hormone (AMH), antral follicle count (AFC) and fertility treatment outcome.
- language
- English
- LU publication?
- yes
- additional info
- 10.1016/j.fertnstert.2024.01.023
- id
- dbdc7208-9834-4806-a11f-a1c41b6bd433
- date added to LUP
- 2024-03-05 15:29:57
- date last changed
- 2024-04-23 17:24:34
@article{dbdc7208-9834-4806-a11f-a1c41b6bd433,
abstract = {{Objective<br/>To study the cumulative live birth rate (CLBR) after the first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment in women with or without deep-infiltrating endometriosis (DIE) and/or endometrioma diagnosed by transvaginal ultrasonography (TVUS), using the International Deep Endometriosis Analysis (IDEA) group definitions.<br/>Design<br/>Prospective observational cohort study at a university hospital.<br/>Patients(s)<br/>In total, 1,040 women with subfertility aged 25 to ≤39 years were undergoing their first IVF/ICSI treatment between January 2019 and October 2022. Of these, 234 (22.5%; 95% confidence interval [CI], 20.0–25.0) women were diagnosed with DIE and/or endometrioma at systematic TVUS before starting their treatment.<br/>Intervention(s)<br/>All women underwent their first IVF or ICSI treatment. Fresh and/or frozen embryos from the first cycle were used until pregnancy was achieved or no embryos remained.<br/>Main Outcome Measure(s)<br/>Cumulative live birth rate after the first IVF/ICSI cycle in women with or without DIE and/or endometrioma.<br/>Result(s)<br/>The CLBR after the first IVF/ICSI treatment in the total cohort of women was 426/1,040 (41.0%; 95% CI, 38.0–44.0). Women with DIE and/or endometrioma had a lower CLBR (78/234, 33.3%; 95% CI, 27.3–39.4) than women without the disease (348/806, 43.2%; 95% CI, 39.8–46.6). The crude relative risk (RR) for cumulative live birth for women with DIE and/or endometrioma was 0.77; 95% CI, 0.63–0.94, and after adjustments were made for age, body mass index, s-antimüllerian hormone, stimulation protocol, and day for embryo transfer, the adjusted RR was 0.63; 95% CI, 0.48–0.82. There was no difference in the number of retrieved mature oocytes, fertilization rate, or good quality embryos between the 2 groups.<br/>Conclusion<br/>The presence of DIE and/or endometrioma diagnosed by TVUS lowers the chance of live birth in women undergoing their first IVF/ICSI treatment.}},
author = {{Alson, Sara and Henic, Emir and Jokubkiene, Ligita and Sladkevicius, Povilas}},
issn = {{1556-5653}},
keywords = {{gynaecology; reproduction; ultrasound; infertility; IVF / ICSI; Endometriosis}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Fertility and Sterility}},
title = {{Endometriosis diagnosed by ultrasound is associated with lower live birth rates in women undergoing their first IVF/ICSI treatment}},
url = {{http://dx.doi.org/10.1016/j.fertnstert.2024.01.023}},
doi = {{10.1016/j.fertnstert.2024.01.023}},
year = {{2024}},
}