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MR Fingerprinting with b-Tensor Encoding for Simultaneous Quantification of Relaxation and Diffusion in a Single Scan

Afzali, Maryam ; Mueller, Lars ; Sakaie, Ken ; Hu, Siyuan ; Chen, Yong ; Szczepankiewicz, Filip LU orcid ; Griswold, Mark A. ; Jones, Derek K. and Ma, Dan (2022) In Magnetic Resonance in Medicine 88(5). p.2043-2057
Abstract

Purpose: Although both relaxation and diffusion imaging are sensitive to tissue microstructure, studies have reported limited sensitivity and robustness of using relaxation or conventional diffusion alone to characterize tissue microstructure. Recently, it has been shown that tensor-valued diffusion encoding and joint relaxation-diffusion quantification enable more reliable quantification of compartment-specific microstructural properties. However, scan times to acquire such data can be prohibitive. Here, we aim to simultaneously quantify relaxation and diffusion using MR fingerprinting (MRF) and b-tensor encoding in a clinically feasible time. Methods: We developed multidimensional MRF scans (mdMRF) with linear and spherical b-tensor... (More)

Purpose: Although both relaxation and diffusion imaging are sensitive to tissue microstructure, studies have reported limited sensitivity and robustness of using relaxation or conventional diffusion alone to characterize tissue microstructure. Recently, it has been shown that tensor-valued diffusion encoding and joint relaxation-diffusion quantification enable more reliable quantification of compartment-specific microstructural properties. However, scan times to acquire such data can be prohibitive. Here, we aim to simultaneously quantify relaxation and diffusion using MR fingerprinting (MRF) and b-tensor encoding in a clinically feasible time. Methods: We developed multidimensional MRF scans (mdMRF) with linear and spherical b-tensor encoding (LTE and STE) to simultaneously quantify T1, T2, and ADC maps from a single scan. The image quality, accuracy, and scan efficiency were compared between the mdMRF using LTE and STE. Moreover, we investigated the robustness of different sequence designs to signal errors and their impact on the maps. Results: T1 and T2 maps derived from the mdMRF scans have consistently high image quality, while ADC maps are sensitive to different sequence designs. Notably, the fast imaging steady state precession (FISP)-based mdMRF scan with peripheral pulse gating provides the best ADC maps that are free of image distortion and shading artifacts. Conclusion: We demonstrated the feasibility of quantifying T1, T2, and ADC maps simultaneously from a single mdMRF scan in around 24 s/slice. The map quality and quantitative values are consistent with the reference scans.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
b-tensor encoding, diffusion imaging, magnetic resonance fingerprinting, multidimensional MRF, quantitative MR, relaxometry
in
Magnetic Resonance in Medicine
volume
88
issue
5
pages
15 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85131921971
  • pmid:35713357
ISSN
0740-3194
DOI
10.1002/mrm.29352
language
English
LU publication?
yes
id
dbdcb373-5191-4e43-9717-7645e5b61d53
date added to LUP
2022-09-29 13:15:31
date last changed
2024-06-13 19:49:21
@article{dbdcb373-5191-4e43-9717-7645e5b61d53,
  abstract     = {{<p>Purpose: Although both relaxation and diffusion imaging are sensitive to tissue microstructure, studies have reported limited sensitivity and robustness of using relaxation or conventional diffusion alone to characterize tissue microstructure. Recently, it has been shown that tensor-valued diffusion encoding and joint relaxation-diffusion quantification enable more reliable quantification of compartment-specific microstructural properties. However, scan times to acquire such data can be prohibitive. Here, we aim to simultaneously quantify relaxation and diffusion using MR fingerprinting (MRF) and b-tensor encoding in a clinically feasible time. Methods: We developed multidimensional MRF scans (mdMRF) with linear and spherical b-tensor encoding (LTE and STE) to simultaneously quantify T1, T2, and ADC maps from a single scan. The image quality, accuracy, and scan efficiency were compared between the mdMRF using LTE and STE. Moreover, we investigated the robustness of different sequence designs to signal errors and their impact on the maps. Results: T1 and T2 maps derived from the mdMRF scans have consistently high image quality, while ADC maps are sensitive to different sequence designs. Notably, the fast imaging steady state precession (FISP)-based mdMRF scan with peripheral pulse gating provides the best ADC maps that are free of image distortion and shading artifacts. Conclusion: We demonstrated the feasibility of quantifying T1, T2, and ADC maps simultaneously from a single mdMRF scan in around 24 s/slice. The map quality and quantitative values are consistent with the reference scans.</p>}},
  author       = {{Afzali, Maryam and Mueller, Lars and Sakaie, Ken and Hu, Siyuan and Chen, Yong and Szczepankiewicz, Filip and Griswold, Mark A. and Jones, Derek K. and Ma, Dan}},
  issn         = {{0740-3194}},
  keywords     = {{b-tensor encoding; diffusion imaging; magnetic resonance fingerprinting; multidimensional MRF; quantitative MR; relaxometry}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{2043--2057}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Magnetic Resonance in Medicine}},
  title        = {{MR Fingerprinting with b-Tensor Encoding for Simultaneous Quantification of Relaxation and Diffusion in a Single Scan}},
  url          = {{http://dx.doi.org/10.1002/mrm.29352}},
  doi          = {{10.1002/mrm.29352}},
  volume       = {{88}},
  year         = {{2022}},
}