The majority of MRSA colonized children not given eradication treatment are still colonized one year later. Systemic antibiotics improve the eradication rate
(2018) In Infectious Diseases 50(9). p.687-696- Abstract
Background: Colonization with methicillin-resistant Staphylococcus aureus (MRSA) can cause endogenously derived infections and be a source of transmission to other people. Neither colonization time of asymptomatic MRSA colonization nor the effect of treatment aiming at MRSA eradication in children has been thoroughly investigated. Methods: Two hundred ninety-three children <18 years in the mandatory follow-up program for MRSA-carriers in Malmö, Sweden were evaluated. Samples from the throat, nares, perineum and skin lesions from each child were screened for MRSA with a PCR-based broth enrichment method. PVL presence and spa-type were evaluated in a majority of cases. The sampling was repeated approximately every 6 month after initial... (More)
Background: Colonization with methicillin-resistant Staphylococcus aureus (MRSA) can cause endogenously derived infections and be a source of transmission to other people. Neither colonization time of asymptomatic MRSA colonization nor the effect of treatment aiming at MRSA eradication in children has been thoroughly investigated. Methods: Two hundred ninety-three children <18 years in the mandatory follow-up program for MRSA-carriers in Malmö, Sweden were evaluated. Samples from the throat, nares, perineum and skin lesions from each child were screened for MRSA with a PCR-based broth enrichment method. PVL presence and spa-type were evaluated in a majority of cases. The sampling was repeated approximately every 6 month after initial detection. When three consecutive sets of negative samples during at least a 6-month period were obtained, the MRSA was considered permanently eradicated. MRSA eradication treatment given, on clinical grounds during follow-up, was noted. Results: One year after detection 62% of the untreated children were still MRSA positive and after 2 years 28%. MRSA throat colonization and having MRSA positive household contacts significantly prolonged the observed colonization time. Topical MRSA eradication treatment was successful in 36% of cases and in 65% if systemic antibiotics were added. Presence of PVL correlated with shorter observed colonization time in the older age group and with increased eradication success among throat carriers. Conclusion: MRSA throat colonization and having MRSA positive household contacts prolongs the time of MRSA colonization in children. Systemic antibiotics enhance the effect of MRSA eradication treatment.
(Less)
- author
- Jörgensen, Jimmy LU ; Månsson, Fredrik LU ; Janson, Håkan LU ; Petersson, Ann Cathrine LU and Nilsson, Anna C. LU
- organization
- publishing date
- 2018-09-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Carrier, Children, Colonization time, Eradication treatment, MRSA, Risk factors
- in
- Infectious Diseases
- volume
- 50
- issue
- 9
- pages
- 687 - 696
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:29688141
- scopus:85046494592
- ISSN
- 2374-4235
- DOI
- 10.1080/23744235.2018.1459828
- language
- English
- LU publication?
- yes
- id
- dbec8953-73c0-4896-8c81-00c6fbee3e5f
- date added to LUP
- 2018-05-15 10:51:47
- date last changed
- 2024-08-19 17:56:37
@article{dbec8953-73c0-4896-8c81-00c6fbee3e5f, abstract = {{<p>Background: Colonization with methicillin-resistant Staphylococcus aureus (MRSA) can cause endogenously derived infections and be a source of transmission to other people. Neither colonization time of asymptomatic MRSA colonization nor the effect of treatment aiming at MRSA eradication in children has been thoroughly investigated. Methods: Two hundred ninety-three children <18 years in the mandatory follow-up program for MRSA-carriers in Malmö, Sweden were evaluated. Samples from the throat, nares, perineum and skin lesions from each child were screened for MRSA with a PCR-based broth enrichment method. PVL presence and spa-type were evaluated in a majority of cases. The sampling was repeated approximately every 6 month after initial detection. When three consecutive sets of negative samples during at least a 6-month period were obtained, the MRSA was considered permanently eradicated. MRSA eradication treatment given, on clinical grounds during follow-up, was noted. Results: One year after detection 62% of the untreated children were still MRSA positive and after 2 years 28%. MRSA throat colonization and having MRSA positive household contacts significantly prolonged the observed colonization time. Topical MRSA eradication treatment was successful in 36% of cases and in 65% if systemic antibiotics were added. Presence of PVL correlated with shorter observed colonization time in the older age group and with increased eradication success among throat carriers. Conclusion: MRSA throat colonization and having MRSA positive household contacts prolongs the time of MRSA colonization in children. Systemic antibiotics enhance the effect of MRSA eradication treatment.</p>}}, author = {{Jörgensen, Jimmy and Månsson, Fredrik and Janson, Håkan and Petersson, Ann Cathrine and Nilsson, Anna C.}}, issn = {{2374-4235}}, keywords = {{Carrier; Children; Colonization time; Eradication treatment; MRSA; Risk factors}}, language = {{eng}}, month = {{09}}, number = {{9}}, pages = {{687--696}}, publisher = {{Informa Healthcare}}, series = {{Infectious Diseases}}, title = {{The majority of MRSA colonized children not given eradication treatment are still colonized one year later. Systemic antibiotics improve the eradication rate}}, url = {{http://dx.doi.org/10.1080/23744235.2018.1459828}}, doi = {{10.1080/23744235.2018.1459828}}, volume = {{50}}, year = {{2018}}, }