Persisters—as elusive as ever
Kaldalu, Niilo ; Hauryliuk, Vasili LU
and Tenson, Tanel
(2016)
In Applied Microbiology and Biotechnology
100(15).
p.6545-6553
- Abstract
Persisters—a drug-tolerant sub-population in an isogenic bacterial culture—have been featured throughout the last decade due to their important role in recurrent bacterial infections. Numerous investigations detail the mechanisms responsible for the formation of persisters and suggest exciting strategies for their eradication. In this review, we argue that the very term “persistence” is currently used to describe a large and heterogeneous set of physiological phenomena that are functions of bacterial species, strains, growth conditions, and antibiotics used in the experiments. We caution against the oversimplification of the mechanisms of persistence and urge for a more rigorous validation of the applicability of these mechanisms in... (More)
Persisters—a drug-tolerant sub-population in an isogenic bacterial culture—have been featured throughout the last decade due to their important role in recurrent bacterial infections. Numerous investigations detail the mechanisms responsible for the formation of persisters and suggest exciting strategies for their eradication. In this review, we argue that the very term “persistence” is currently used to describe a large and heterogeneous set of physiological phenomena that are functions of bacterial species, strains, growth conditions, and antibiotics used in the experiments. We caution against the oversimplification of the mechanisms of persistence and urge for a more rigorous validation of the applicability of these mechanisms in each case.
(Less)
- author
- Kaldalu, Niilo
; Hauryliuk, Vasili
LU
and Tenson, Tanel
- publishing date
- 2016-08-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Antibiotic development, Antibiotic resistance, Antibiotic tolerance, Bacterial infections, Bet hedging, Persisters
- in
- Applied Microbiology and Biotechnology
- volume
- 100
- issue
- 15
- pages
- 9 pages
- publisher
- Springer
- external identifiers
-
- scopus:84978168312
- pmid:27262568
- ISSN
- 0175-7598
- DOI
- 10.1007/s00253-016-7648-8
- language
- English
- LU publication?
- no
- additional info
- Funding Information: This study was funded by Estonian Research Council grant IUT 2–22 (T.T.), Estonian Research Council grant PUT37 (V.H.), Swedish Research Council grant 2013–4680 (V.H), Kempe Foundation (V.H.), Ragnar Söderberg Foundation (V.H.), and European Regional Development Fund through the Center of Excellence in Molecular Cell Engineering (T.T.). Publisher Copyright: © 2016, The Author(s). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
- id
- dc113e71-7130-4da5-8ca6-3acc185fb4f4
- date added to LUP
- 2021-09-24 20:44:34
- date last changed
- 2024-06-15 17:19:04
@article{dc113e71-7130-4da5-8ca6-3acc185fb4f4,
abstract = {{<p>Persisters—a drug-tolerant sub-population in an isogenic bacterial culture—have been featured throughout the last decade due to their important role in recurrent bacterial infections. Numerous investigations detail the mechanisms responsible for the formation of persisters and suggest exciting strategies for their eradication. In this review, we argue that the very term “persistence” is currently used to describe a large and heterogeneous set of physiological phenomena that are functions of bacterial species, strains, growth conditions, and antibiotics used in the experiments. We caution against the oversimplification of the mechanisms of persistence and urge for a more rigorous validation of the applicability of these mechanisms in each case.</p>}},
author = {{Kaldalu, Niilo and Hauryliuk, Vasili and Tenson, Tanel}},
issn = {{0175-7598}},
keywords = {{Antibiotic development; Antibiotic resistance; Antibiotic tolerance; Bacterial infections; Bet hedging; Persisters}},
language = {{eng}},
month = {{08}},
number = {{15}},
pages = {{6545--6553}},
publisher = {{Springer}},
series = {{Applied Microbiology and Biotechnology}},
title = {{Persisters—as elusive as ever}},
url = {{http://dx.doi.org/10.1007/s00253-016-7648-8}},
doi = {{10.1007/s00253-016-7648-8}},
volume = {{100}},
year = {{2016}},
}