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Clusters of risk factors in metabolic syndrome and their influence on central blood pressure in a global study

Laucyte-Cibulskiene, Agne LU orcid ; Chen, Chen Huan ; Cockroft, John ; Cunha, Pedro G. ; Kavousi, Maryam ; Laucevicius, Aleksandras ; Muiesan, Maria Lorenza ; Rietzschel, Ernst R. ; Ryliskyte, Ligita and Strazhesko, Irina D. , et al. (2022) In Scientific Reports 12(1).
Abstract

The effect of metabolic syndrome (MetS) and clusters of its components on central blood pressure (CBP) has not been well characterized. We aimed to describe the effect of MetS and clusters of its components on CBP in a large population and to identify whether this effect differs in men and women. We studied 15,609 volunteers (43% women) from 10 cohorts worldwide who participated in the Metabolic syndrome and Artery REsearch Consortium. MetS was defined according to the NCEP-ATP III criteria (GHTBW, glucose, high-density lipoprotein cholesterol, triglyceride, blood pressure, waist circumference). CBP was measured noninvasively and acquired from pulse wave analysis by applanation tonometry. MetS was associated with a 50% greater odds of... (More)

The effect of metabolic syndrome (MetS) and clusters of its components on central blood pressure (CBP) has not been well characterized. We aimed to describe the effect of MetS and clusters of its components on CBP in a large population and to identify whether this effect differs in men and women. We studied 15,609 volunteers (43% women) from 10 cohorts worldwide who participated in the Metabolic syndrome and Artery REsearch Consortium. MetS was defined according to the NCEP-ATP III criteria (GHTBW, glucose, high-density lipoprotein cholesterol, triglyceride, blood pressure, waist circumference). CBP was measured noninvasively and acquired from pulse wave analysis by applanation tonometry. MetS was associated with a 50% greater odds of having higher CSBP. After controlling for age, male sex, non HDL cholesterol, diabetes mellitus, and mean arterial pressure, only specific clusters of MetS components were associated with a higher CSBP; and some of them were significant in women but not in men. We identified “risky clusters” of MetS variables associated with high CSBP. Future studies are needed to confirm they identify subjects at high risk of accelerated arterial aging and, thus, need more intensive clinical management.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
12
issue
1
article number
14409
publisher
Nature Publishing Group
external identifiers
  • pmid:36002468
  • scopus:85136486138
ISSN
2045-2322
DOI
10.1038/s41598-022-18094-y
language
English
LU publication?
yes
id
dc1d4c04-a974-4795-8423-d6a29a55d94d
date added to LUP
2022-12-29 10:58:45
date last changed
2024-04-04 15:06:23
@article{dc1d4c04-a974-4795-8423-d6a29a55d94d,
  abstract     = {{<p>The effect of metabolic syndrome (MetS) and clusters of its components on central blood pressure (CBP) has not been well characterized. We aimed to describe the effect of MetS and clusters of its components on CBP in a large population and to identify whether this effect differs in men and women. We studied 15,609 volunteers (43% women) from 10 cohorts worldwide who participated in the Metabolic syndrome and Artery REsearch Consortium. MetS was defined according to the NCEP-ATP III criteria (GHTBW, glucose, high-density lipoprotein cholesterol, triglyceride, blood pressure, waist circumference). CBP was measured noninvasively and acquired from pulse wave analysis by applanation tonometry. MetS was associated with a 50% greater odds of having higher CSBP. After controlling for age, male sex, non HDL cholesterol, diabetes mellitus, and mean arterial pressure, only specific clusters of MetS components were associated with a higher CSBP; and some of them were significant in women but not in men. We identified “risky clusters” of MetS variables associated with high CSBP. Future studies are needed to confirm they identify subjects at high risk of accelerated arterial aging and, thus, need more intensive clinical management.</p>}},
  author       = {{Laucyte-Cibulskiene, Agne and Chen, Chen Huan and Cockroft, John and Cunha, Pedro G. and Kavousi, Maryam and Laucevicius, Aleksandras and Muiesan, Maria Lorenza and Rietzschel, Ernst R. and Ryliskyte, Ligita and Strazhesko, Irina D. and Vlachopoulos, Charalambos and Cotter, Jorge and Dudinskaya, Ekatherina N. and Gale, Nichola and Ahmadizar, Fariba and Mattace-Raso, Francesco U.S. and Munnery, Maggie and Oliveira, Pedro and Paini, Anna and Salvetti, Massimo and Tkacheva, Olga N. and Lakatta, Edward G. and Nilsson, Peter M. and Scuteri, Angelo}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Clusters of risk factors in metabolic syndrome and their influence on central blood pressure in a global study}},
  url          = {{http://dx.doi.org/10.1038/s41598-022-18094-y}},
  doi          = {{10.1038/s41598-022-18094-y}},
  volume       = {{12}},
  year         = {{2022}},
}