Goodpasture's syndrome with concomitant immune complex mixed membranous and proliferative glomerulonephritis
(2014) In Clinical Nephrology 81(3). p.216-223- Abstract
- Classical Goodpasture's (GP) syndrome is a monophasic illness characterized by pulmonary hemorrhage and rapidly progressive glomerulonephritis with linear IgG deposition along the glomerular and distal tubular basement membrane and destructive necrotizing diffuse extracapillary crescentic glomerulonephritis. The majority of patients have circulating anti-glomerular basement membrane (GBM) antibodies, detectable with standard anti-GBM ELISA. Concurrence of GP syndrome with proliferative glomerulonephritis has only rarely been described. In this report, for the first time we describe in a 21-year-old woman GP syndrome with 50% crescentic sclerosing glomerulonephritis with linear immunofluorescence characteristic of anti-GBM pathogenesis,... (More)
- Classical Goodpasture's (GP) syndrome is a monophasic illness characterized by pulmonary hemorrhage and rapidly progressive glomerulonephritis with linear IgG deposition along the glomerular and distal tubular basement membrane and destructive necrotizing diffuse extracapillary crescentic glomerulonephritis. The majority of patients have circulating anti-glomerular basement membrane (GBM) antibodies, detectable with standard anti-GBM ELISA. Concurrence of GP syndrome with proliferative glomerulonephritis has only rarely been described. In this report, for the first time we describe in a 21-year-old woman GP syndrome with 50% crescentic sclerosing glomerulonephritis with linear immunofluorescence characteristic of anti-GBM pathogenesis, combined with mixed membranous and membranoproliferative glomerulonephritis with granular immunofluorescence and subepithelial, mesangial and subendothelial deposits characterizing immune complex pathogenesis. The clinical picture was also unusual for GP syndrome, manifesting a recurrent but non-progressive course, nephrotic syndrome, normal renal function and low values of anti-GBM antibodies, identified only by novel more sensitive techniques. (Less)
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https://lup.lub.lu.se/record/4871865
- author
- Jurcic, Vesna ; Vizjak, Alenka ; Rigler, Andreja Ales ; Jeruc, Jera ; Wieslander, Jörgen LU and Ferluga, Dusan
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Goodpasture's syndrome, anti-GBM, membranous glomerulonephritis, membranoproliferative glomerulonephritis
- in
- Clinical Nephrology
- volume
- 81
- issue
- 3
- pages
- 216 - 223
- publisher
- Dustri-Verlag
- external identifiers
-
- wos:000344794600011
- scopus:84894042225
- pmid:23320965
- ISSN
- 0301-0430
- DOI
- 10.5414/CN107454
- language
- English
- LU publication?
- yes
- id
- dc206ed6-6048-4e4c-985e-b0ccb7090cb7 (old id 4871865)
- date added to LUP
- 2016-04-01 13:45:27
- date last changed
- 2022-01-27 20:53:59
@article{dc206ed6-6048-4e4c-985e-b0ccb7090cb7,
abstract = {{Classical Goodpasture's (GP) syndrome is a monophasic illness characterized by pulmonary hemorrhage and rapidly progressive glomerulonephritis with linear IgG deposition along the glomerular and distal tubular basement membrane and destructive necrotizing diffuse extracapillary crescentic glomerulonephritis. The majority of patients have circulating anti-glomerular basement membrane (GBM) antibodies, detectable with standard anti-GBM ELISA. Concurrence of GP syndrome with proliferative glomerulonephritis has only rarely been described. In this report, for the first time we describe in a 21-year-old woman GP syndrome with 50% crescentic sclerosing glomerulonephritis with linear immunofluorescence characteristic of anti-GBM pathogenesis, combined with mixed membranous and membranoproliferative glomerulonephritis with granular immunofluorescence and subepithelial, mesangial and subendothelial deposits characterizing immune complex pathogenesis. The clinical picture was also unusual for GP syndrome, manifesting a recurrent but non-progressive course, nephrotic syndrome, normal renal function and low values of anti-GBM antibodies, identified only by novel more sensitive techniques.}},
author = {{Jurcic, Vesna and Vizjak, Alenka and Rigler, Andreja Ales and Jeruc, Jera and Wieslander, Jörgen and Ferluga, Dusan}},
issn = {{0301-0430}},
keywords = {{Goodpasture's syndrome; anti-GBM; membranous glomerulonephritis; membranoproliferative glomerulonephritis}},
language = {{eng}},
number = {{3}},
pages = {{216--223}},
publisher = {{Dustri-Verlag}},
series = {{Clinical Nephrology}},
title = {{Goodpasture's syndrome with concomitant immune complex mixed membranous and proliferative glomerulonephritis}},
url = {{http://dx.doi.org/10.5414/CN107454}},
doi = {{10.5414/CN107454}},
volume = {{81}},
year = {{2014}},
}