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Prediction of Consolidation Tumor Ratio on Planning CT Images of Lung Cancer Patients Treated with Radiotherapy Based on Deep Learning

Tong, Yizhi ; Arimura, Hidetaka ; Yoshitake, Tadamasa ; Cui, Yunhao ; Kodama, Takumi ; Shioyama, Yoshiyuki ; Wirestam, Ronnie LU orcid and Yabuuchi, Hidetake (2024) In Applied Sciences (Switzerland) 14(8).
Abstract

This study aimed to propose an automated prediction approach of the consolidation tumor ratios (CTRs) of part-solid tumors of patients treated with radiotherapy on treatment planning computed tomography images using deep learning segmentation (DLS) models. For training the DLS model for cancer regions, a total of 115 patients with non-small cell lung cancer (NSCLC) who underwent stereotactic body radiation therapy were selected as the training dataset, including solid, part-solid, and ground-glass opacity tumors. For testing the automated prediction approach of CTRs based on segmented tumor regions, 38 patients with part-solid tumors were selected as an internal test dataset A (IN) from a same institute as the training dataset, and 49... (More)

This study aimed to propose an automated prediction approach of the consolidation tumor ratios (CTRs) of part-solid tumors of patients treated with radiotherapy on treatment planning computed tomography images using deep learning segmentation (DLS) models. For training the DLS model for cancer regions, a total of 115 patients with non-small cell lung cancer (NSCLC) who underwent stereotactic body radiation therapy were selected as the training dataset, including solid, part-solid, and ground-glass opacity tumors. For testing the automated prediction approach of CTRs based on segmented tumor regions, 38 patients with part-solid tumors were selected as an internal test dataset A (IN) from a same institute as the training dataset, and 49 patients as an external test dataset (EX) from a public database. The CTRs for part-solid tumors were predicted as ratios of the maximum diameters of solid components to those of whole tumors. Pearson correlations between reference and predicted CTRs for the two test datasets were 0.953 (IN) and 0.926 (EX) for one of the DLS models (p < 0.01). Intraclass correlation coefficients between reference and predicted CTRs for the two test datasets were 0.943 (IN) and 0.904 (EX) for the same DLS models. The findings suggest that the automated prediction approach could be robust in calculating the CTRs of part-solid tumors.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
consolidation tumor ratio, deep learning, independent test, non-small cell lung cancer (NSCLC), part-solid tumors
in
Applied Sciences (Switzerland)
volume
14
issue
8
article number
3275
publisher
MDPI AG
external identifiers
  • scopus:85192515904
ISSN
2076-3417
DOI
10.3390/app14083275
language
English
LU publication?
yes
id
dc2a11b1-8605-42e4-b0d0-92806d885247
date added to LUP
2024-05-23 15:51:42
date last changed
2024-05-23 15:52:57
@article{dc2a11b1-8605-42e4-b0d0-92806d885247,
  abstract     = {{<p>This study aimed to propose an automated prediction approach of the consolidation tumor ratios (CTRs) of part-solid tumors of patients treated with radiotherapy on treatment planning computed tomography images using deep learning segmentation (DLS) models. For training the DLS model for cancer regions, a total of 115 patients with non-small cell lung cancer (NSCLC) who underwent stereotactic body radiation therapy were selected as the training dataset, including solid, part-solid, and ground-glass opacity tumors. For testing the automated prediction approach of CTRs based on segmented tumor regions, 38 patients with part-solid tumors were selected as an internal test dataset A (IN) from a same institute as the training dataset, and 49 patients as an external test dataset (EX) from a public database. The CTRs for part-solid tumors were predicted as ratios of the maximum diameters of solid components to those of whole tumors. Pearson correlations between reference and predicted CTRs for the two test datasets were 0.953 (IN) and 0.926 (EX) for one of the DLS models (p &lt; 0.01). Intraclass correlation coefficients between reference and predicted CTRs for the two test datasets were 0.943 (IN) and 0.904 (EX) for the same DLS models. The findings suggest that the automated prediction approach could be robust in calculating the CTRs of part-solid tumors.</p>}},
  author       = {{Tong, Yizhi and Arimura, Hidetaka and Yoshitake, Tadamasa and Cui, Yunhao and Kodama, Takumi and Shioyama, Yoshiyuki and Wirestam, Ronnie and Yabuuchi, Hidetake}},
  issn         = {{2076-3417}},
  keywords     = {{consolidation tumor ratio; deep learning; independent test; non-small cell lung cancer (NSCLC); part-solid tumors}},
  language     = {{eng}},
  number       = {{8}},
  publisher    = {{MDPI AG}},
  series       = {{Applied Sciences (Switzerland)}},
  title        = {{Prediction of Consolidation Tumor Ratio on Planning CT Images of Lung Cancer Patients Treated with Radiotherapy Based on Deep Learning}},
  url          = {{http://dx.doi.org/10.3390/app14083275}},
  doi          = {{10.3390/app14083275}},
  volume       = {{14}},
  year         = {{2024}},
}