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Design and control of integrated chromatography column sequences

Andersson, Niklas LU ; Löfgren, Anton LU ; Olofsson, Marianne LU ; Sellberg, Anton LU ; Nilsson, Bernt LU and Tiainen, Peter (2017) In Biotechnology Progress 00(00).
Abstract
To increase the productivity in biopharmaceutical production, a natural step is to introduce integrated continuous biomanufacturing which leads to fewer buffer and storage tanks, smaller sizes of integrated unit operations, and full automation of the operation. The main contribution of this work is to illustrate a methodology for design and control of a downstream process based on integrated column sequences. For small scale production, for example, pre-clinical studies, integrated column sequences can be implemented on a single chromatography system. This makes for a very efficient drug development platform. The proposed methodology is composed of four steps and is governed by a set of tools, that is presented, that makes the transition... (More)
To increase the productivity in biopharmaceutical production, a natural step is to introduce integrated continuous biomanufacturing which leads to fewer buffer and storage tanks, smaller sizes of integrated unit operations, and full automation of the operation. The main contribution of this work is to illustrate a methodology for design and control of a downstream process based on integrated column sequences. For small scale production, for example, pre-clinical studies, integrated column sequences can be implemented on a single chromatography system. This makes for a very efficient drug development platform. The proposed methodology is composed of four steps and is governed by a set of tools, that is presented, that makes the transition from batch separations to a complete integrated separation sequence as easy as possible. This methodology, its associated tools and the physical implementation is presented and illustrated on a case study where the target protein is separated from impurities through an integrated four column sequence. This article shows that the design and control of an integrated column sequence was successfully implemented for a tertiary protein separation problem. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biotechnology Progress
volume
00
issue
00
pages
8 pages
publisher
The American Chemical Society
external identifiers
  • scopus:85011684970
ISSN
1520-6033
DOI
10.1002/btpr.2434
language
English
LU publication?
yes
id
dc3de375-febf-4d95-a7af-f6fc99fccfdb
date added to LUP
2017-06-08 09:23:40
date last changed
2017-06-15 10:46:43
@article{dc3de375-febf-4d95-a7af-f6fc99fccfdb,
  abstract     = {To increase the productivity in biopharmaceutical production, a natural step is to introduce integrated continuous biomanufacturing which leads to fewer buffer and storage tanks, smaller sizes of integrated unit operations, and full automation of the operation. The main contribution of this work is to illustrate a methodology for design and control of a downstream process based on integrated column sequences. For small scale production, for example, pre-clinical studies, integrated column sequences can be implemented on a single chromatography system. This makes for a very efficient drug development platform. The proposed methodology is composed of four steps and is governed by a set of tools, that is presented, that makes the transition from batch separations to a complete integrated separation sequence as easy as possible. This methodology, its associated tools and the physical implementation is presented and illustrated on a case study where the target protein is separated from impurities through an integrated four column sequence. This article shows that the design and control of an integrated column sequence was successfully implemented for a tertiary protein separation problem. },
  author       = {Andersson, Niklas and Löfgren, Anton and Olofsson, Marianne and Sellberg, Anton and Nilsson, Bernt and Tiainen, Peter},
  issn         = {1520-6033},
  language     = {eng},
  month        = {02},
  number       = {00},
  pages        = {8},
  publisher    = {The American Chemical Society},
  series       = {Biotechnology Progress},
  title        = {Design and control of integrated chromatography column sequences},
  url          = {http://dx.doi.org/10.1002/btpr.2434},
  volume       = {00},
  year         = {2017},
}