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The Effectiveness and Tolerability of a Very Low-Volume Bowel Preparation for Colonoscopy Compared to Low and High-Volume Polyethylene Glycol-Solutions in the Real-Life Setting

Bednarska, Olga ; Nyhlin, Nils ; Schmidt, Peter Thelin ; Johansson, Gabriele Wurm LU ; Toth, Ervin LU and Lindfors, Perjohan (2022) In Diagnostics 12(5).
Abstract

Adequate bowel cleansing is essential for high-quality colonoscopy. Recently, a new very low-volume 1 litre (1L) polyethylene glycol (PEG) plus ascorbate solution (ASC) has been introduced. Our aims were to assess the effectiveness and tolerability of this product compared to low-volume 2L PEG-ASC and high-volume 4L PEG solutions, in a real-life setting. In six endoscopy units in Sweden, outpatients undergoing colonoscopy were either prescribed solutions according to local routines, or the very low-volume solution in split dose regimen. Bowel cleansing effectiveness and patient experience was assessed using the Boston Bowel preparation scale (BBPS) and a patient questionnaire. A total of 1098 patients (mean age 58 years, 52% women) were... (More)

Adequate bowel cleansing is essential for high-quality colonoscopy. Recently, a new very low-volume 1 litre (1L) polyethylene glycol (PEG) plus ascorbate solution (ASC) has been introduced. Our aims were to assess the effectiveness and tolerability of this product compared to low-volume 2L PEG-ASC and high-volume 4L PEG solutions, in a real-life setting. In six endoscopy units in Sweden, outpatients undergoing colonoscopy were either prescribed solutions according to local routines, or the very low-volume solution in split dose regimen. Bowel cleansing effectiveness and patient experience was assessed using the Boston Bowel preparation scale (BBPS) and a patient questionnaire. A total of 1098 patients (mean age 58 years, 52% women) were included. All subsegment and the total BBPS scores were significantly greater for 1L PEG-ASC in comparison to other solutions (p < 0.05 for 1L PEG-ASC and 4L PEG for transverse and left colon, otherwise p < 0.001). Nausea was more frequent with 1L PEG-ASC compared to 2L PEG-ASC (p < 0.001) and vomiting were more often reported compared to both other solutions (p < 0.01 and p < 0.05 for 2L PEG-ASC and 4L PEG, respectively). Smell, taste, and total experience was better for 1L PEG-ASC compared to 4L PEG (p < 0.001), and similar compared to the 2L PEG-ASC. In conclusion, 1L PEG-ASC leads to better bowel cleansing compared to 2L PEG-ASC or 4L PEG products, with similar or greater patient satisfaction.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bowel preparation, colonoscopy, effectiveness, polyethylene glycol, polyethylene glycol plus ascorbate, tolerability
in
Diagnostics
volume
12
issue
5
article number
1155
publisher
MDPI AG
external identifiers
  • scopus:85130185189
  • pmid:35626310
ISSN
2075-4418
DOI
10.3390/diagnostics12051155
language
English
LU publication?
yes
id
dc490b29-17ae-4847-bb58-17ccb2da2d55
date added to LUP
2022-12-08 11:25:56
date last changed
2024-12-13 13:00:27
@article{dc490b29-17ae-4847-bb58-17ccb2da2d55,
  abstract     = {{<p>Adequate bowel cleansing is essential for high-quality colonoscopy. Recently, a new very low-volume 1 litre (1L) polyethylene glycol (PEG) plus ascorbate solution (ASC) has been introduced. Our aims were to assess the effectiveness and tolerability of this product compared to low-volume 2L PEG-ASC and high-volume 4L PEG solutions, in a real-life setting. In six endoscopy units in Sweden, outpatients undergoing colonoscopy were either prescribed solutions according to local routines, or the very low-volume solution in split dose regimen. Bowel cleansing effectiveness and patient experience was assessed using the Boston Bowel preparation scale (BBPS) and a patient questionnaire. A total of 1098 patients (mean age 58 years, 52% women) were included. All subsegment and the total BBPS scores were significantly greater for 1L PEG-ASC in comparison to other solutions (p &lt; 0.05 for 1L PEG-ASC and 4L PEG for transverse and left colon, otherwise p &lt; 0.001). Nausea was more frequent with 1L PEG-ASC compared to 2L PEG-ASC (p &lt; 0.001) and vomiting were more often reported compared to both other solutions (p &lt; 0.01 and p &lt; 0.05 for 2L PEG-ASC and 4L PEG, respectively). Smell, taste, and total experience was better for 1L PEG-ASC compared to 4L PEG (p &lt; 0.001), and similar compared to the 2L PEG-ASC. In conclusion, 1L PEG-ASC leads to better bowel cleansing compared to 2L PEG-ASC or 4L PEG products, with similar or greater patient satisfaction.</p>}},
  author       = {{Bednarska, Olga and Nyhlin, Nils and Schmidt, Peter Thelin and Johansson, Gabriele Wurm and Toth, Ervin and Lindfors, Perjohan}},
  issn         = {{2075-4418}},
  keywords     = {{bowel preparation; colonoscopy; effectiveness; polyethylene glycol; polyethylene glycol plus ascorbate; tolerability}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{MDPI AG}},
  series       = {{Diagnostics}},
  title        = {{The Effectiveness and Tolerability of a Very Low-Volume Bowel Preparation for Colonoscopy Compared to Low and High-Volume Polyethylene Glycol-Solutions in the Real-Life Setting}},
  url          = {{http://dx.doi.org/10.3390/diagnostics12051155}},
  doi          = {{10.3390/diagnostics12051155}},
  volume       = {{12}},
  year         = {{2022}},
}