Platelet-activating factor (Paf-acether) formation in neonatal intestinal mucosa and in cultured intestinal epithelial cells
(1992) In European Surgical Research 24(6). p.325-332- Abstract
We report the presence of platelet-activating factor (PAF-acether; l-0-alkyl-2-acetyl-.v«-glycero-3-phosphocholine) in small-intestinal and colonic mucosa of neonatal rats. The PAF-acether content was higher in the colon than in the small intestine, and was lower in the small intestine of 30-day-old animals than in 14-day-old animals. We also report that cultured intestinal epithelial cells (INT 407) produce PAF-acether when stimulated with the calcium ionophore A23187, and that homogenized INT 407 cells can degrade PAF-acether with the formation of lysoPAF-acethcr. These findings suggest that intestinal epithelial cells are able to produce and metabolize PAF-acether, a potent mediator of inflammation. The authors propose that this... (More)
We report the presence of platelet-activating factor (PAF-acether; l-0-alkyl-2-acetyl-.v«-glycero-3-phosphocholine) in small-intestinal and colonic mucosa of neonatal rats. The PAF-acether content was higher in the colon than in the small intestine, and was lower in the small intestine of 30-day-old animals than in 14-day-old animals. We also report that cultured intestinal epithelial cells (INT 407) produce PAF-acether when stimulated with the calcium ionophore A23187, and that homogenized INT 407 cells can degrade PAF-acether with the formation of lysoPAF-acethcr. These findings suggest that intestinal epithelial cells are able to produce and metabolize PAF-acether, a potent mediator of inflammation. The authors propose that this might contribute to the pathophysiology of inflammatory bowel disease.
(Less)
- author
- Kald, B. ; Gustajson, C. ; Franzen, L. LU ; Westrom, B. LU ; Sjodahl, R. and Tagesson, C.
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Inflammation, Intestinal epithelial cells, Neonatal intestinal mucosa, PAF-acether generation
- in
- European Surgical Research
- volume
- 24
- issue
- 6
- pages
- 8 pages
- publisher
- Karger
- external identifiers
-
- scopus:0027048427
- pmid:1292936
- ISSN
- 0014-312X
- DOI
- 10.1159/000129224
- language
- English
- LU publication?
- yes
- id
- dc81bd23-087f-4156-b8d3-8433983b2e1e
- date added to LUP
- 2024-12-05 15:31:28
- date last changed
- 2025-04-04 14:41:22
@article{dc81bd23-087f-4156-b8d3-8433983b2e1e,
abstract = {{<p>We report the presence of platelet-activating factor (PAF-acether; l-0-alkyl-2-acetyl-.v«-glycero-3-phosphocholine) in small-intestinal and colonic mucosa of neonatal rats. The PAF-acether content was higher in the colon than in the small intestine, and was lower in the small intestine of 30-day-old animals than in 14-day-old animals. We also report that cultured intestinal epithelial cells (INT 407) produce PAF-acether when stimulated with the calcium ionophore A23187, and that homogenized INT 407 cells can degrade PAF-acether with the formation of lysoPAF-acethcr. These findings suggest that intestinal epithelial cells are able to produce and metabolize PAF-acether, a potent mediator of inflammation. The authors propose that this might contribute to the pathophysiology of inflammatory bowel disease.</p>}},
author = {{Kald, B. and Gustajson, C. and Franzen, L. and Westrom, B. and Sjodahl, R. and Tagesson, C.}},
issn = {{0014-312X}},
keywords = {{Inflammation; Intestinal epithelial cells; Neonatal intestinal mucosa; PAF-acether generation}},
language = {{eng}},
number = {{6}},
pages = {{325--332}},
publisher = {{Karger}},
series = {{European Surgical Research}},
title = {{Platelet-activating factor (Paf-acether) formation in neonatal intestinal mucosa and in cultured intestinal epithelial cells}},
url = {{http://dx.doi.org/10.1159/000129224}},
doi = {{10.1159/000129224}},
volume = {{24}},
year = {{1992}},
}