Tena, a Drosophila gene related to tenascin, shows selective transcript localization
Baumgartner, Stefan LU
and Chiquet-Ehrismann, Ruth
(1993)
In Mechanisms of Development
40(3).
p.165-176
- Abstract
We report the identification and molecular characterization of tena*, a Drosophila gene located at 11A6-9 on the X-chromosome. The deduced protein of 782 amino acids contains eight tenascin-type EGF-like repeats not described in Drosophila before, but lacks the fibronectin type III repeats and the fibrinogen homology present in the vertebrate tenascin molecules. Tena codes for a large transcript which exhibits extremely long 5′ and 3′ untranslates regions. Tena transcripts show a specific perinuclear localization within cells and are mainly expressed in the central nervous system, in the brain and near muscle attachment sites during embryogenesis. During pupal stages, tena is detected in the... (More)
We report the identification and molecular characterization of tena*, a Drosophila gene located at 11A6-9 on the X-chromosome. The deduced protein of 782 amino acids contains eight tenascin-type EGF-like repeats not described in Drosophila before, but lacks the fibronectin type III repeats and the fibrinogen homology present in the vertebrate tenascin molecules. Tena codes for a large transcript which exhibits extremely long 5′ and 3′ untranslates regions. Tena transcripts show a specific perinuclear localization within cells and are mainly expressed in the central nervous system, in the brain and near muscle attachment sites during embryogenesis. During pupal stages, tena is detected in the eye. These expression patterns are reminiscent of those of vertebrate tenascin. Tenascin-type EFG-like sequences are also detected in other loci of Drosophila and in various other organisms, indicating the existence of a family of genes related to tenascin.
(Less)
- author
- Baumgartner, Stefan
LU
and Chiquet-Ehrismann, Ruth
- publishing date
- 1993-01-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Drosophila, Epidermal growth factor, Localized RNA, ten, Tenascin
- in
- Mechanisms of Development
- volume
- 40
- issue
- 3
- pages
- 165 - 176
- publisher
- Elsevier
- external identifiers
-
- pmid:7684246
- scopus:0027339605
- ISSN
- 0925-4773
- DOI
- 10.1016/0925-4773(93)90074-8
- language
- English
- LU publication?
- no
- id
- dc82f660-2aec-4d9c-a1d5-b77e5c93ac26
- date added to LUP
- 2019-05-21 14:09:18
- date last changed
- 2024-01-01 05:55:34
@article{dc82f660-2aec-4d9c-a1d5-b77e5c93ac26,
abstract = {{<p>We report the identification and molecular characterization of ten<sup>a*</sup>, a Drosophila gene located at 11A6-9 on the X-chromosome. The deduced protein of 782 amino acids contains eight tenascin-type EGF-like repeats not described in Drosophila before, but lacks the fibronectin type III repeats and the fibrinogen homology present in the vertebrate tenascin molecules. Ten<sup>a</sup> codes for a large transcript which exhibits extremely long 5′ and 3′ untranslates regions. Ten<sup>a</sup> transcripts show a specific perinuclear localization within cells and are mainly expressed in the central nervous system, in the brain and near muscle attachment sites during embryogenesis. During pupal stages, ten<sup>a</sup> is detected in the eye. These expression patterns are reminiscent of those of vertebrate tenascin. Tenascin-type EFG-like sequences are also detected in other loci of Drosophila and in various other organisms, indicating the existence of a family of genes related to tenascin.</p>}},
author = {{Baumgartner, Stefan and Chiquet-Ehrismann, Ruth}},
issn = {{0925-4773}},
keywords = {{Drosophila; Epidermal growth factor; Localized RNA; ten; Tenascin}},
language = {{eng}},
month = {{01}},
number = {{3}},
pages = {{165--176}},
publisher = {{Elsevier}},
series = {{Mechanisms of Development}},
title = {{Ten<sup>a</sup>, a Drosophila gene related to tenascin, shows selective transcript localization}},
url = {{http://dx.doi.org/10.1016/0925-4773(93)90074-8}},
doi = {{10.1016/0925-4773(93)90074-8}},
volume = {{40}},
year = {{1993}},
}