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Deconstructing tumor heterogeneity : The stromal perspective

Vickman, Renee E. ; Faget, Douglas V. ; Beachy, Philip ; Beebe, David ; Bhowmick, Neil A. ; Cukierman, Edna ; Deng, Wu Min ; Granneman, James G. ; Hildesheim, Jeffrey and Kalluri, Raghu , et al. (2020) In Oncotarget 11(40). p.3621-3632
Abstract

Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression, and recurrence, however, the roles of additional stromal elements, cell types and/or cell states remain ill-defined. The overarching goal of this NCI-sponsored workshop was to highlight and integrate the critical functions of non-immune stromal components in regulating tumor heterogeneity and its impact on tumor initiation, progression, and resistance to therapy. The workshop explored the opposing roles of tumor supportive versus suppressive stroma and how cellular composition and function may be altered during disease progression. It also highlighted microenvironment-centered... (More)

Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression, and recurrence, however, the roles of additional stromal elements, cell types and/or cell states remain ill-defined. The overarching goal of this NCI-sponsored workshop was to highlight and integrate the critical functions of non-immune stromal components in regulating tumor heterogeneity and its impact on tumor initiation, progression, and resistance to therapy. The workshop explored the opposing roles of tumor supportive versus suppressive stroma and how cellular composition and function may be altered during disease progression. It also highlighted microenvironment-centered mechanisms dictating indolence or aggressiveness of early lesions and how spatial geography impacts stromal attributes and function. The prognostic and therapeutic implications as well as potential vulnerabilities within the heterogeneous tumor microenvironment were also discussed. These broad topics were included in this workshop as an effort to identify current challenges and knowledge gaps in the field.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cellular plasticity, Extracellular matrix, Stromal heterogeneity, Therapy resistance, Tumor microenvironment
in
Oncotarget
volume
11
issue
40
pages
12 pages
publisher
Impact Journals
external identifiers
  • scopus:85094595628
ISSN
1949-2553
DOI
10.18632/ONCOTARGET.27736
language
English
LU publication?
yes
id
dc8849bc-5567-404d-866d-e894bf92cea6
date added to LUP
2020-11-17 09:04:01
date last changed
2022-04-26 21:49:22
@article{dc8849bc-5567-404d-866d-e894bf92cea6,
  abstract     = {{<p>Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression, and recurrence, however, the roles of additional stromal elements, cell types and/or cell states remain ill-defined. The overarching goal of this NCI-sponsored workshop was to highlight and integrate the critical functions of non-immune stromal components in regulating tumor heterogeneity and its impact on tumor initiation, progression, and resistance to therapy. The workshop explored the opposing roles of tumor supportive versus suppressive stroma and how cellular composition and function may be altered during disease progression. It also highlighted microenvironment-centered mechanisms dictating indolence or aggressiveness of early lesions and how spatial geography impacts stromal attributes and function. The prognostic and therapeutic implications as well as potential vulnerabilities within the heterogeneous tumor microenvironment were also discussed. These broad topics were included in this workshop as an effort to identify current challenges and knowledge gaps in the field.</p>}},
  author       = {{Vickman, Renee E. and Faget, Douglas V. and Beachy, Philip and Beebe, David and Bhowmick, Neil A. and Cukierman, Edna and Deng, Wu Min and Granneman, James G. and Hildesheim, Jeffrey and Kalluri, Raghu and Lau, Ken S. and Lengyel, Ernst and Lundeberg, Joakim and Moscat, Jorge and Nelson, Peter S. and Pietras, Kristian and Politi, Katerina and Puré, Ellen and Scherz-Shouval, Ruth and Sherman, Mara H. and Tuveson, David and Weeraratna, Ashani T. and White, Richard M. and Wong, Melissa H. and Woodhouse, Elisa C. and Zheng, Ying and Hayward, Simon W. and Stewart, Sheila A.}},
  issn         = {{1949-2553}},
  keywords     = {{Cellular plasticity; Extracellular matrix; Stromal heterogeneity; Therapy resistance; Tumor microenvironment}},
  language     = {{eng}},
  number       = {{40}},
  pages        = {{3621--3632}},
  publisher    = {{Impact Journals}},
  series       = {{Oncotarget}},
  title        = {{Deconstructing tumor heterogeneity : The stromal perspective}},
  url          = {{http://dx.doi.org/10.18632/ONCOTARGET.27736}},
  doi          = {{10.18632/ONCOTARGET.27736}},
  volume       = {{11}},
  year         = {{2020}},
}