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Fat loss in continuous enteral feeding of the preterm infant : How much, what and when is it lost?

Zozaya, Carlos ; García-Serrano, Alba LU ; Fontecha, Javier ; Redondo-Bravo, Lidia ; Sánchez-González, Victoria ; Montes, María Teresa and de Pipaón, Miguel Saenz (2018) In Nutrients 10(7).
Abstract

Human milk fat is a concentrated source of energy and provides essential and long chain polyunsaturated fatty acids. According to previous experiments, human milk fat is partially lost during continuous enteral nutrition. However, these experiments were done over relatively short infusion times, and a complete profile of the lost fatty acids was never measured. Whether this loss happens considering longer infusion times or if some fatty acids are lost more than others remain unknown. Pooled breast milk was infused through a feeding tube by a peristaltic pump over a period of 30 min and 4, 12 and 24 h at 2 mL/h. Adsorbed fat was extracted from the tubes, and the fatty acid composition was analyzed by gas chromatography-mass spectrometry.... (More)

Human milk fat is a concentrated source of energy and provides essential and long chain polyunsaturated fatty acids. According to previous experiments, human milk fat is partially lost during continuous enteral nutrition. However, these experiments were done over relatively short infusion times, and a complete profile of the lost fatty acids was never measured. Whether this loss happens considering longer infusion times or if some fatty acids are lost more than others remain unknown. Pooled breast milk was infused through a feeding tube by a peristaltic pump over a period of 30 min and 4, 12 and 24 h at 2 mL/h. Adsorbed fat was extracted from the tubes, and the fatty acid composition was analyzed by gas chromatography-mass spectrometry. Total fat loss (average fatty acid loss) after 24 h was 0.6 ± 0.1%. Total fat loss after 24 h infusion was 0.6 ± 0.1% of the total fat infused, although the highest losses occur in the first 30 min of infusion (13.0 ± 1.6%). Short-medium chain (0.7%, p = 0.15), long chain (0.6%, p = 0.56), saturated (0.7%, p = 0.4), monounsaturated (0.5%, p = 0.15), polyunsaturated fatty (0.7%, p = 0.15), linoleic (0.7%, p = 0.25), and docosahexaenoic acids (0.6%, p = 0.56) were not selectively adsorbed to the tube. However, very long chain fatty (0.9%, p = 0.04), alpha-linolenic (1.6%, p = 0.02) and arachidonic acids (1%, p = 0.02) were selectively adsorbed and, therefore, lost in a greater proportion than other fatty acids. In all cases, the magnitude of the loss was clinically low.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Arachidonic acid, Docosahexaenoic acid, Enteral nutrition, Lipids, Long-chain polyunsaturated fatty acids, Omega-3 fatty acids, Omega-6 fatty acids, Preterm infant
in
Nutrients
volume
10
issue
7
article number
809
publisher
MDPI AG
external identifiers
  • pmid:29937492
  • scopus:85049111956
ISSN
2072-6643
DOI
10.3390/nu10070809
language
English
LU publication?
no
id
dcba18c8-2c07-4d7f-8432-9ae703899891
date added to LUP
2019-10-08 15:21:57
date last changed
2021-02-17 08:10:39
@article{dcba18c8-2c07-4d7f-8432-9ae703899891,
  abstract     = {<p>Human milk fat is a concentrated source of energy and provides essential and long chain polyunsaturated fatty acids. According to previous experiments, human milk fat is partially lost during continuous enteral nutrition. However, these experiments were done over relatively short infusion times, and a complete profile of the lost fatty acids was never measured. Whether this loss happens considering longer infusion times or if some fatty acids are lost more than others remain unknown. Pooled breast milk was infused through a feeding tube by a peristaltic pump over a period of 30 min and 4, 12 and 24 h at 2 mL/h. Adsorbed fat was extracted from the tubes, and the fatty acid composition was analyzed by gas chromatography-mass spectrometry. Total fat loss (average fatty acid loss) after 24 h was 0.6 ± 0.1%. Total fat loss after 24 h infusion was 0.6 ± 0.1% of the total fat infused, although the highest losses occur in the first 30 min of infusion (13.0 ± 1.6%). Short-medium chain (0.7%, p = 0.15), long chain (0.6%, p = 0.56), saturated (0.7%, p = 0.4), monounsaturated (0.5%, p = 0.15), polyunsaturated fatty (0.7%, p = 0.15), linoleic (0.7%, p = 0.25), and docosahexaenoic acids (0.6%, p = 0.56) were not selectively adsorbed to the tube. However, very long chain fatty (0.9%, p = 0.04), alpha-linolenic (1.6%, p = 0.02) and arachidonic acids (1%, p = 0.02) were selectively adsorbed and, therefore, lost in a greater proportion than other fatty acids. In all cases, the magnitude of the loss was clinically low.</p>},
  author       = {Zozaya, Carlos and García-Serrano, Alba and Fontecha, Javier and Redondo-Bravo, Lidia and Sánchez-González, Victoria and Montes, María Teresa and de Pipaón, Miguel Saenz},
  issn         = {2072-6643},
  language     = {eng},
  number       = {7},
  publisher    = {MDPI AG},
  series       = {Nutrients},
  title        = {Fat loss in continuous enteral feeding of the preterm infant : How much, what and when is it lost?},
  url          = {http://dx.doi.org/10.3390/nu10070809},
  doi          = {10.3390/nu10070809},
  volume       = {10},
  year         = {2018},
}