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Plasma concentration of Caspase-8 is associated with short sleep duration and the risk of incident diabetes mellitus

Svensson, Thomas LU ; Svensson, Akiko Kishi LU ; Kitlinski, Mariusz LU ; Almgren, Peter LU ; Engström, Gunnar LU ; Nilsson, Jan LU ; Orho-Melander, Marju LU ; Nilsson, Peter M LU and Melander, Olle LU orcid (2018) In The Journal of clinical endocrinology and metabolism 103(4). p.1592-1600
Abstract

Context: The biological mechanism for the association between sleep duration and incident diabetes mellitus (DM) is unclear. Sleep duration and Caspase-8, a marker of apoptotic activity, have both been implicated in beta cell function.

Objective: To investigate the associations between sleep duration and plasma Caspase-8, and incident DM, respectively.

Design: Prospective cohort study.

Setting: The Malmö Diet and Cancer (MDC) Study is a population-based, prospective study run in the city of Malmö, Sweden.

Participants: 4023 individuals from the MDC Study aged 45-68 years at baseline without a history of prevalent DM, and with information on habitual sleep duration.

Main outcomes: Incident DM.

Results:... (More)

Context: The biological mechanism for the association between sleep duration and incident diabetes mellitus (DM) is unclear. Sleep duration and Caspase-8, a marker of apoptotic activity, have both been implicated in beta cell function.

Objective: To investigate the associations between sleep duration and plasma Caspase-8, and incident DM, respectively.

Design: Prospective cohort study.

Setting: The Malmö Diet and Cancer (MDC) Study is a population-based, prospective study run in the city of Malmö, Sweden.

Participants: 4023 individuals from the MDC Study aged 45-68 years at baseline without a history of prevalent DM, and with information on habitual sleep duration.

Main outcomes: Incident DM.

Results: Mean follow-up time was 17.8 years. Sleep duration was the only behavioural variable significantly associated with plasma Caspase-8. Plasma Caspase-8 was significantly associated with incident DM per standard deviation of its transformed continuous form (hazard ratio [HR]= 1.24, 95% confidence interval [CI] 1.13-1.36), and when dichotomized into high (quartile 4) (HR=1.44, 95%CI: 1.19-1.74) compared to low (quartiles 1-3) concentrations. Caspase-8 interacted with sleep duration; compared to 7-8 hours of sleep and low plasma Caspase-8, individuals with high plasma Caspase-8 and sleep duration <6 hours (HR=3.54, 95%CI: 2.12-5.90), 6-7 hours (HR=1.81, 95%CI: 1.24-2.65), and 8-9 hours (HR=1.54, 95%CI: 1.09-2.18) were at significantly increased risks of incident DM.

Conclusions: Sleep duration is associated with plasma Caspase-8. Caspase-8 independently predicts DM years before disease onset and modifies the effect of sleep duration on incident DM. Future studies should investigate if change of sleep duration modifies plasma concentrations of Caspase-8.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of clinical endocrinology and metabolism
volume
103
issue
4
pages
9 pages
publisher
Oxford University Press
external identifiers
  • pmid:29409058
  • scopus:85045467292
ISSN
1945-7197
DOI
10.1210/jc.2017-02374
language
English
LU publication?
yes
id
dcbe2994-14f9-4791-9e91-ae51f80a0d6b
date added to LUP
2018-03-28 02:42:02
date last changed
2024-05-13 07:34:04
@article{dcbe2994-14f9-4791-9e91-ae51f80a0d6b,
  abstract     = {{<p>Context: The biological mechanism for the association between sleep duration and incident diabetes mellitus (DM) is unclear. Sleep duration and Caspase-8, a marker of apoptotic activity, have both been implicated in beta cell function.</p><p>Objective: To investigate the associations between sleep duration and plasma Caspase-8, and incident DM, respectively.</p><p>Design: Prospective cohort study.</p><p>Setting: The Malmö Diet and Cancer (MDC) Study is a population-based, prospective study run in the city of Malmö, Sweden.</p><p>Participants: 4023 individuals from the MDC Study aged 45-68 years at baseline without a history of prevalent DM, and with information on habitual sleep duration.</p><p>Main outcomes: Incident DM.</p><p>Results: Mean follow-up time was 17.8 years. Sleep duration was the only behavioural variable significantly associated with plasma Caspase-8. Plasma Caspase-8 was significantly associated with incident DM per standard deviation of its transformed continuous form (hazard ratio [HR]= 1.24, 95% confidence interval [CI] 1.13-1.36), and when dichotomized into high (quartile 4) (HR=1.44, 95%CI: 1.19-1.74) compared to low (quartiles 1-3) concentrations. Caspase-8 interacted with sleep duration; compared to 7-8 hours of sleep and low plasma Caspase-8, individuals with high plasma Caspase-8 and sleep duration &lt;6 hours (HR=3.54, 95%CI: 2.12-5.90), 6-7 hours (HR=1.81, 95%CI: 1.24-2.65), and 8-9 hours (HR=1.54, 95%CI: 1.09-2.18) were at significantly increased risks of incident DM.</p><p>Conclusions: Sleep duration is associated with plasma Caspase-8. Caspase-8 independently predicts DM years before disease onset and modifies the effect of sleep duration on incident DM. Future studies should investigate if change of sleep duration modifies plasma concentrations of Caspase-8.</p>}},
  author       = {{Svensson, Thomas and Svensson, Akiko Kishi and Kitlinski, Mariusz and Almgren, Peter and Engström, Gunnar and Nilsson, Jan and Orho-Melander, Marju and Nilsson, Peter M and Melander, Olle}},
  issn         = {{1945-7197}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  pages        = {{1592--1600}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of clinical endocrinology and metabolism}},
  title        = {{Plasma concentration of Caspase-8 is associated with short sleep duration and the risk of incident diabetes mellitus}},
  url          = {{http://dx.doi.org/10.1210/jc.2017-02374}},
  doi          = {{10.1210/jc.2017-02374}},
  volume       = {{103}},
  year         = {{2018}},
}