Plasma concentration of Caspase-8 is associated with short sleep duration and the risk of incident diabetes mellitus
(2018) In The Journal of clinical endocrinology and metabolism 103(4). p.1592-1600- Abstract
Context: The biological mechanism for the association between sleep duration and incident diabetes mellitus (DM) is unclear. Sleep duration and Caspase-8, a marker of apoptotic activity, have both been implicated in beta cell function.
Objective: To investigate the associations between sleep duration and plasma Caspase-8, and incident DM, respectively.
Design: Prospective cohort study.
Setting: The Malmö Diet and Cancer (MDC) Study is a population-based, prospective study run in the city of Malmö, Sweden.
Participants: 4023 individuals from the MDC Study aged 45-68 years at baseline without a history of prevalent DM, and with information on habitual sleep duration.
Main outcomes: Incident DM.
Results:... (More)
Context: The biological mechanism for the association between sleep duration and incident diabetes mellitus (DM) is unclear. Sleep duration and Caspase-8, a marker of apoptotic activity, have both been implicated in beta cell function.
Objective: To investigate the associations between sleep duration and plasma Caspase-8, and incident DM, respectively.
Design: Prospective cohort study.
Setting: The Malmö Diet and Cancer (MDC) Study is a population-based, prospective study run in the city of Malmö, Sweden.
Participants: 4023 individuals from the MDC Study aged 45-68 years at baseline without a history of prevalent DM, and with information on habitual sleep duration.
Main outcomes: Incident DM.
Results: Mean follow-up time was 17.8 years. Sleep duration was the only behavioural variable significantly associated with plasma Caspase-8. Plasma Caspase-8 was significantly associated with incident DM per standard deviation of its transformed continuous form (hazard ratio [HR]= 1.24, 95% confidence interval [CI] 1.13-1.36), and when dichotomized into high (quartile 4) (HR=1.44, 95%CI: 1.19-1.74) compared to low (quartiles 1-3) concentrations. Caspase-8 interacted with sleep duration; compared to 7-8 hours of sleep and low plasma Caspase-8, individuals with high plasma Caspase-8 and sleep duration <6 hours (HR=3.54, 95%CI: 2.12-5.90), 6-7 hours (HR=1.81, 95%CI: 1.24-2.65), and 8-9 hours (HR=1.54, 95%CI: 1.09-2.18) were at significantly increased risks of incident DM.
Conclusions: Sleep duration is associated with plasma Caspase-8. Caspase-8 independently predicts DM years before disease onset and modifies the effect of sleep duration on incident DM. Future studies should investigate if change of sleep duration modifies plasma concentrations of Caspase-8.
(Less)
- author
- Svensson, Thomas LU ; Svensson, Akiko Kishi LU ; Kitlinski, Mariusz LU ; Almgren, Peter LU ; Engström, Gunnar LU ; Nilsson, Jan LU ; Orho-Melander, Marju LU ; Nilsson, Peter M LU and Melander, Olle LU
- organization
-
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Hypertension (research group)
- Diabetes - Cardiovascular Disease (research group)
- Cardiovascular Research - Epidemiology (research group)
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- Internal Medicine - Epidemiology (research group)
- publishing date
- 2018-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of clinical endocrinology and metabolism
- volume
- 103
- issue
- 4
- pages
- 9 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:29409058
- scopus:85045467292
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2017-02374
- project
- Sleep Duration, Cardiometabolic disease and Mortality: Proteomic links with incident diabetes
- language
- English
- LU publication?
- yes
- id
- dcbe2994-14f9-4791-9e91-ae51f80a0d6b
- date added to LUP
- 2018-03-28 02:42:02
- date last changed
- 2024-09-02 18:05:59
@article{dcbe2994-14f9-4791-9e91-ae51f80a0d6b, abstract = {{<p>Context: The biological mechanism for the association between sleep duration and incident diabetes mellitus (DM) is unclear. Sleep duration and Caspase-8, a marker of apoptotic activity, have both been implicated in beta cell function.</p><p>Objective: To investigate the associations between sleep duration and plasma Caspase-8, and incident DM, respectively.</p><p>Design: Prospective cohort study.</p><p>Setting: The Malmö Diet and Cancer (MDC) Study is a population-based, prospective study run in the city of Malmö, Sweden.</p><p>Participants: 4023 individuals from the MDC Study aged 45-68 years at baseline without a history of prevalent DM, and with information on habitual sleep duration.</p><p>Main outcomes: Incident DM.</p><p>Results: Mean follow-up time was 17.8 years. Sleep duration was the only behavioural variable significantly associated with plasma Caspase-8. Plasma Caspase-8 was significantly associated with incident DM per standard deviation of its transformed continuous form (hazard ratio [HR]= 1.24, 95% confidence interval [CI] 1.13-1.36), and when dichotomized into high (quartile 4) (HR=1.44, 95%CI: 1.19-1.74) compared to low (quartiles 1-3) concentrations. Caspase-8 interacted with sleep duration; compared to 7-8 hours of sleep and low plasma Caspase-8, individuals with high plasma Caspase-8 and sleep duration <6 hours (HR=3.54, 95%CI: 2.12-5.90), 6-7 hours (HR=1.81, 95%CI: 1.24-2.65), and 8-9 hours (HR=1.54, 95%CI: 1.09-2.18) were at significantly increased risks of incident DM.</p><p>Conclusions: Sleep duration is associated with plasma Caspase-8. Caspase-8 independently predicts DM years before disease onset and modifies the effect of sleep duration on incident DM. Future studies should investigate if change of sleep duration modifies plasma concentrations of Caspase-8.</p>}}, author = {{Svensson, Thomas and Svensson, Akiko Kishi and Kitlinski, Mariusz and Almgren, Peter and Engström, Gunnar and Nilsson, Jan and Orho-Melander, Marju and Nilsson, Peter M and Melander, Olle}}, issn = {{1945-7197}}, language = {{eng}}, month = {{04}}, number = {{4}}, pages = {{1592--1600}}, publisher = {{Oxford University Press}}, series = {{The Journal of clinical endocrinology and metabolism}}, title = {{Plasma concentration of Caspase-8 is associated with short sleep duration and the risk of incident diabetes mellitus}}, url = {{http://dx.doi.org/10.1210/jc.2017-02374}}, doi = {{10.1210/jc.2017-02374}}, volume = {{103}}, year = {{2018}}, }