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A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants

Nilsson, Sofie LU orcid ; Tokariev, Anton ; Metsäranta, Marjo ; Norman, Elisabeth LU and Vanhatalo, Sampsa LU (2023) In Sensors 23(1).
Abstract

Background: Data on the cerebral effects of analgesic and sedative drugs are needed for the development of safe and effective treatments during neonatal intensive care. Electroencephalography (EEG) is an objective, but interpreter-dependent method for monitoring cortical activity. Quantitative computerized analyses might reveal EEG changes otherwise not detectable. Methods: EEG registrations were retrospectively collected from 21 infants (mean 38.7 gestational weeks; range 27–42) who received dexmedetomidine during neonatal care. The registrations were transformed into computational features and analyzed visually, and with two computational measures quantifying relative and absolute changes in power (range EEG; rEEG) and... (More)

Background: Data on the cerebral effects of analgesic and sedative drugs are needed for the development of safe and effective treatments during neonatal intensive care. Electroencephalography (EEG) is an objective, but interpreter-dependent method for monitoring cortical activity. Quantitative computerized analyses might reveal EEG changes otherwise not detectable. Methods: EEG registrations were retrospectively collected from 21 infants (mean 38.7 gestational weeks; range 27–42) who received dexmedetomidine during neonatal care. The registrations were transformed into computational features and analyzed visually, and with two computational measures quantifying relative and absolute changes in power (range EEG; rEEG) and cortico-cortical synchrony (activation synchrony index; ASI), respectively. Results: The visual assessment did not reveal any drug effects. In rEEG analyses, a negative correlation was found between the baseline and the referential frontal (rho = 0.612, p = 0.006) and parietal (rho = −0.489, p = 0.035) derivations. The change in ASI was negatively correlated to baseline values in the interhemispheric (rho = −0.753; p = 0.001) and frontal comparisons (rho = −0.496; p = 0.038). Conclusion: Cerebral effects of dexmedetomidine as determined by EEG in newborn infants are related to cortical activity prior to DEX administration, indicating that higher brain activity levels (higher rEEG) during baseline links to a more pronounced reduction by DEX. The computational measurements indicate drug effects on both overall cortical activity and cortico-cortical communication. These effects were not evident in visual analysis.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
brain monitoring, dexmedetomidine, EEG analysis, newborn, sedative drug
in
Sensors
volume
23
issue
1
article number
444
publisher
MDPI AG
external identifiers
  • pmid:36617042
  • scopus:85145878862
ISSN
1424-8220
DOI
10.3390/s23010444
language
English
LU publication?
yes
id
dcd5b651-b4d8-487e-959f-7ff851f6bb94
date added to LUP
2023-02-15 15:29:46
date last changed
2024-06-14 00:02:32
@article{dcd5b651-b4d8-487e-959f-7ff851f6bb94,
  abstract     = {{<p>Background: Data on the cerebral effects of analgesic and sedative drugs are needed for the development of safe and effective treatments during neonatal intensive care. Electroencephalography (EEG) is an objective, but interpreter-dependent method for monitoring cortical activity. Quantitative computerized analyses might reveal EEG changes otherwise not detectable. Methods: EEG registrations were retrospectively collected from 21 infants (mean 38.7 gestational weeks; range 27–42) who received dexmedetomidine during neonatal care. The registrations were transformed into computational features and analyzed visually, and with two computational measures quantifying relative and absolute changes in power (range EEG; rEEG) and cortico-cortical synchrony (activation synchrony index; ASI), respectively. Results: The visual assessment did not reveal any drug effects. In rEEG analyses, a negative correlation was found between the baseline and the referential frontal (rho = 0.612, p = 0.006) and parietal (rho = −0.489, p = 0.035) derivations. The change in ASI was negatively correlated to baseline values in the interhemispheric (rho = −0.753; p = 0.001) and frontal comparisons (rho = −0.496; p = 0.038). Conclusion: Cerebral effects of dexmedetomidine as determined by EEG in newborn infants are related to cortical activity prior to DEX administration, indicating that higher brain activity levels (higher rEEG) during baseline links to a more pronounced reduction by DEX. The computational measurements indicate drug effects on both overall cortical activity and cortico-cortical communication. These effects were not evident in visual analysis.</p>}},
  author       = {{Nilsson, Sofie and Tokariev, Anton and Metsäranta, Marjo and Norman, Elisabeth and Vanhatalo, Sampsa}},
  issn         = {{1424-8220}},
  keywords     = {{brain monitoring; dexmedetomidine; EEG analysis; newborn; sedative drug}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{MDPI AG}},
  series       = {{Sensors}},
  title        = {{A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants}},
  url          = {{http://dx.doi.org/10.3390/s23010444}},
  doi          = {{10.3390/s23010444}},
  volume       = {{23}},
  year         = {{2023}},
}