Advanced

The genome sequence of taurine cattle : a window to ruminant biology and evolution

Elsik, Christine G ; Tellam, Ross L ; Worley, Kim C ; Gibbs, Richard A ; Muzny, Donna M ; Weinstock, George M ; Adelson, David L ; Eichler, Evan E ; Elnitski, Laura and Guigó, Roderic , et al. (2009) In Science (New York, N.Y.) 324(5926). p.522-528
Abstract

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome... (More)

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
author collaboration
publishing date
type
Contribution to journal
publication status
published
keywords
Alternative Splicing, Animals, Animals, Domestic, Biological Evolution, Cattle, Evolution, Molecular, Female, Genetic Variation, Genome, Humans, Male, MicroRNAs/genetics, Molecular Sequence Data, Proteins/genetics, Sequence Analysis, DNA, Species Specificity, Synteny
in
Science (New York, N.Y.)
volume
324
issue
5926
pages
522 - 528
publisher
American Association for the Advancement of Science
external identifiers
  • pmid:19390049
  • scopus:77951621301
ISSN
1095-9203
DOI
10.1126/science.1169588
language
English
LU publication?
no
id
dce27a5d-5fbf-47ca-88b6-837769643de9
date added to LUP
2019-11-10 16:51:22
date last changed
2020-05-26 05:35:09
@article{dce27a5d-5fbf-47ca-88b6-837769643de9,
  abstract     = {<p>To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.</p>},
  author       = {Elsik, Christine G and Tellam, Ross L and Worley, Kim C and Gibbs, Richard A and Muzny, Donna M and Weinstock, George M and Adelson, David L and Eichler, Evan E and Elnitski, Laura and Guigó, Roderic and Hamernik, Debora L and Kappes, Steve M and Lewin, Harris A and Lynn, David J and Nicholas, Frank W and Reymond, Alexandre and Rijnkels, Monique and Skow, Loren C and Zdobnov, Evgeny M and Schook, Lawrence and Womack, James and Alioto, Tyler and Antonarakis, Stylianos E and Astashyn, Alex and Chapple, Charles E and Chen, Hsiu-Chuan and Chrast, Jacqueline and Câmara, Francisco and Ermolaeva, Olga and Henrichsen, Charlotte N and Hlavina, Wratko and Kapustin, Yuri and Kiryutin, Boris and Kitts, Paul and Kokocinski, Felix and Landrum, Melissa and Maglott, Donna and Pruitt, Kim and Sapojnikov, Victor and Searle, Stephen M and Souvorov, Alexandre and Solovyev, Victor and Ucla, Catherine and Wyss, Carine and Anzola, Juan M and Gerlach, Daniel and Elhaik, Eran and Lau, Lilian P L and Baxter, Rebecca and Ding, Yan},
  issn         = {1095-9203},
  language     = {eng},
  month        = {04},
  number       = {5926},
  pages        = {522--528},
  publisher    = {American Association for the Advancement of Science},
  series       = {Science (New York, N.Y.)},
  title        = {The genome sequence of taurine cattle : a window to ruminant biology and evolution},
  url          = {http://dx.doi.org/10.1126/science.1169588},
  doi          = {10.1126/science.1169588},
  volume       = {324},
  year         = {2009},
}