Nicotine does not affect plasma lipoprotein concentrations in healthy men
(1989) In Scandinavian Journal of Clinical & Laboratory Investigation 49(2). p.149-153- Abstract
- The effects of nicotine administration (2 mg eight-times daily as nicotine chewing gum for two weeks) on plasma lipid and lipoprotein concentrations were studied in young healthy volunteers. Plasma levels of the nicotine metabolite, cotinine, reached levels comparable to those seen in smokers. Plasma concentrations of triglyceride, cholesterol, HDL cholesterol, LDL cholesterol, and apolipoproteins AI and B, were determined repeatedly before, during and after cessation of nicotine intake. All these variables, as well as the activities of lipoprotein lipase and hepatic lipase in post-heparin plasma, remained unchanged throughout the study. The results strongly suggest that the effects of smoking on plasma lipoprotein metabolism are not... (More)
- The effects of nicotine administration (2 mg eight-times daily as nicotine chewing gum for two weeks) on plasma lipid and lipoprotein concentrations were studied in young healthy volunteers. Plasma levels of the nicotine metabolite, cotinine, reached levels comparable to those seen in smokers. Plasma concentrations of triglyceride, cholesterol, HDL cholesterol, LDL cholesterol, and apolipoproteins AI and B, were determined repeatedly before, during and after cessation of nicotine intake. All these variables, as well as the activities of lipoprotein lipase and hepatic lipase in post-heparin plasma, remained unchanged throughout the study. The results strongly suggest that the effects of smoking on plasma lipoprotein metabolism are not mediated via nicotine, and indicate that nicotine chewing gum, when used therapeutically in anti-smoking programmes, does not carry the same metabolic side effects as smoking. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104575
- author
- Quensel, M ; Agardh, Carl-David LU and Nilsson-Ehle, Peter LU
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- plasma lipoproteins, plasma lipids, nicotine intake, lipolytic enzymes, cotinine concentrations
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 49
- issue
- 2
- pages
- 149 - 153
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:2520366
- scopus:0024588516
- ISSN
- 1502-7686
- DOI
- 10.3109/00365518909105414
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510), Division of Clinical Chemistry and Pharmacology (013250300)
- id
- dcfac300-3a73-4524-8224-a81c3e441231 (old id 1104575)
- date added to LUP
- 2016-04-01 17:11:02
- date last changed
- 2021-01-03 08:23:40
@article{dcfac300-3a73-4524-8224-a81c3e441231,
abstract = {{The effects of nicotine administration (2 mg eight-times daily as nicotine chewing gum for two weeks) on plasma lipid and lipoprotein concentrations were studied in young healthy volunteers. Plasma levels of the nicotine metabolite, cotinine, reached levels comparable to those seen in smokers. Plasma concentrations of triglyceride, cholesterol, HDL cholesterol, LDL cholesterol, and apolipoproteins AI and B, were determined repeatedly before, during and after cessation of nicotine intake. All these variables, as well as the activities of lipoprotein lipase and hepatic lipase in post-heparin plasma, remained unchanged throughout the study. The results strongly suggest that the effects of smoking on plasma lipoprotein metabolism are not mediated via nicotine, and indicate that nicotine chewing gum, when used therapeutically in anti-smoking programmes, does not carry the same metabolic side effects as smoking.}},
author = {{Quensel, M and Agardh, Carl-David and Nilsson-Ehle, Peter}},
issn = {{1502-7686}},
keywords = {{plasma lipoproteins; plasma lipids; nicotine intake; lipolytic enzymes; cotinine concentrations}},
language = {{eng}},
number = {{2}},
pages = {{149--153}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
title = {{Nicotine does not affect plasma lipoprotein concentrations in healthy men}},
url = {{http://dx.doi.org/10.3109/00365518909105414}},
doi = {{10.3109/00365518909105414}},
volume = {{49}},
year = {{1989}},
}