Reversible Michael additions: Covalent inhibitors and prodrugs.
(2012) In Mini-Reviews in Medicinal Chemistry 12(13). p.1330-1344- Abstract
- Covalent inhibition is an efficient molecular mechanism for inhibiting enzymes or modulating the function of proteins and is found in the action of many drugs and biologically active natural products. However, it is has been less appreciated that the formation of covalent bonds can be reversible or irreversible. This review focuses on biologically active compounds that are Michael acceptors and how the reversible nature of the Michael addition reaction influences biological activity and how this can be exploited in designing prodrugs.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2608516
- author
- Johansson, Martin H LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Mini-Reviews in Medicinal Chemistry
- volume
- 12
- issue
- 13
- pages
- 1330 - 1344
- publisher
- Bentham Science Publishers
- external identifiers
-
- wos:000309968700002
- pmid:22625413
- scopus:84870190055
- ISSN
- 1875-5607
- language
- English
- LU publication?
- yes
- id
- dd06d68a-e559-4b42-b8b7-7e01d75946fc (old id 2608516)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22625413?dopt=Abstract
- date added to LUP
- 2016-04-04 08:56:09
- date last changed
- 2022-04-23 18:36:54
@article{dd06d68a-e559-4b42-b8b7-7e01d75946fc,
abstract = {{Covalent inhibition is an efficient molecular mechanism for inhibiting enzymes or modulating the function of proteins and is found in the action of many drugs and biologically active natural products. However, it is has been less appreciated that the formation of covalent bonds can be reversible or irreversible. This review focuses on biologically active compounds that are Michael acceptors and how the reversible nature of the Michael addition reaction influences biological activity and how this can be exploited in designing prodrugs.}},
author = {{Johansson, Martin H}},
issn = {{1875-5607}},
language = {{eng}},
number = {{13}},
pages = {{1330--1344}},
publisher = {{Bentham Science Publishers}},
series = {{Mini-Reviews in Medicinal Chemistry}},
title = {{Reversible Michael additions: Covalent inhibitors and prodrugs.}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/22625413?dopt=Abstract}},
volume = {{12}},
year = {{2012}},
}