Clinical Studies of EpECT with Bleomycin or Cis-Platin
(2018) In Acta Scientiarum Lundensia 2018. p.1-1- Abstract
- In recent years several authors have reviewed the clinical results of Electro Enhanced Chemotherapy:
• Electro-chemotherapy for primary skin cancer and skin metastasis related to other malignancies (Reinhold, 2011).
• Utility of electro-chemotherapy in melanoma treatment (Testori et al., 2012).
• Antitumor effectiveness of electro-chemotherapy: A systematic review and meta-analysis (Mali et al., 2013).
• Electro-chemotherapy in Breast Cancer: A Review of References (Schmidt et al., 2014).
• Treatments of advanced basal cell carcinoma: a review of the literature" (Peris et al., 2016).
• Treatment efficacy with electro-chemotherapy: A multi-institutional prospective observational study on 376 patients with... (More) - In recent years several authors have reviewed the clinical results of Electro Enhanced Chemotherapy:
• Electro-chemotherapy for primary skin cancer and skin metastasis related to other malignancies (Reinhold, 2011).
• Utility of electro-chemotherapy in melanoma treatment (Testori et al., 2012).
• Antitumor effectiveness of electro-chemotherapy: A systematic review and meta-analysis (Mali et al., 2013).
• Electro-chemotherapy in Breast Cancer: A Review of References (Schmidt et al., 2014).
• Treatments of advanced basal cell carcinoma: a review of the literature" (Peris et al., 2016).
• Treatment efficacy with electro-chemotherapy: A multi-institutional prospective observational study on 376 patients with superficial tumours"(Campana et al., 2016b).
• Basal cell carcinoma: 10-year experience with electro-chemotherapy (Campana et al., 2017b).
• Electro-chemotherapy in Breast Cancer - Discussion of the Method and Literature Review (Wichtowski et al., 2017).
The treatment results are in most cases reported in terms of following quantities where the fractional response
= (No. cases with the actual response / Total No. Cases)
CR = Complete response;
PR = partial response;
SD = stable disease;
PD = progressive disease;
OR = objective response; CR = fractional complete response;
PR = fractional partial response;
SD = fractional stable disease;
PD = fractional progressive disease;
OR = fractional objective response
Usually the sum of complete and partial responses called Objective Response (OR = CR + PR) is used as a general quantity for the response of the treatment in question without considering the responses of stable and progress disease.
In order to be able unify all four quantities into a quantity which consider the total response a quantity named “fractional weighting response”, WR is defined as follow:
In order to estimate the response considering all four response quantities a quantity named “fractional weighted response”, WR is defined as follow:
WR = (3OR + 1PR + 0SD - 3PR)/3;
The following sections summarize the published responses of clinical electro-chemotherapy for each specific type of tumour, and estimate the fractional weighting response from the data of each published report.
(Less) - Abstract (Swedish)
- Under de senaste åren har flera författare granskat de kliniska resultaten av Electro Enhanced Chemotherapy:
• Elektrokemoterapi för primär hudcancer och hudmetastas i samband med andra maligniteter (Reinhold, 2011).
• Utnyttjande av elektrokemoterapi vid behandling av melanom (Testori et al., 2012).
• Antitumörverkan av elektrokemoterapi: En systematisk granskning och meta-analys (Mali et al., 2013).
• Elektrokemoterapi i bröstcancer: En översyn av referenser (Schmidt et al., 2014).
• Behandlingar av avancerat basalcellkarcinom: en genomgång av litteraturen "(Peris et al., 2016).
• Behandlingseffektivitet med elektrokemoterapi: En multinationell prospektiv observationsstudie på 376 patienter med ytliga tumörer... (More) - Under de senaste åren har flera författare granskat de kliniska resultaten av Electro Enhanced Chemotherapy:
• Elektrokemoterapi för primär hudcancer och hudmetastas i samband med andra maligniteter (Reinhold, 2011).
• Utnyttjande av elektrokemoterapi vid behandling av melanom (Testori et al., 2012).
• Antitumörverkan av elektrokemoterapi: En systematisk granskning och meta-analys (Mali et al., 2013).
• Elektrokemoterapi i bröstcancer: En översyn av referenser (Schmidt et al., 2014).
• Behandlingar av avancerat basalcellkarcinom: en genomgång av litteraturen "(Peris et al., 2016).
• Behandlingseffektivitet med elektrokemoterapi: En multinationell prospektiv observationsstudie på 376 patienter med ytliga tumörer "(Campana et al., 2016b).
• Basalcellkarcinom: 10 års erfarenhet av elektrokemoterapi (Campana et al., 2017b).
• Elektrokemoterapi i bröstcancer - Diskussion om Metod och litteraturgranskning (Wichtowski et al., 2017).
Behandlingsresultaten rapporteras i de flesta fall med avseende på följande kvantiteter där fraktionellt svar
= (Antal fall med det faktiska svaret / Totalt antal fall)
CR = komplett svar;
PR = partiell respons;
SD = stabil sjukdom;
PD = progressiv sjukdom;
OR = objektivt svar CR = fraktionalt komplett svar;
PR = fraktionellt partiellt svar
SD = fraktionell stabil sjukdom;
PD = fraktionell progressiv sjukdom;
OR = fraktionellt objektivt svar
Vanligtvis används summan av fullständiga och partiella svar som kallas målrespons (OR = CR + PR) som en allmän kvantitet för svaret på behandlingen i fråga utan att överväga svaren på stabil och framstegssjukdom.
För att kunna kombinera alla fyra kvantiteterna i en kvantitet som anser det totala svaret en kvantitet som heter "fraktionellt viktningssvar" definieras WR som följer:
För att uppskatta svaret med tanke på alla fyra svarkvantiteterna definieras en kvantitet som heter "fraktionerad viktad respons", enligt följande:
WR = (3OR + 1PR + 0SD - 3PR) / 3;
I det här kapitlet sammanfattas de publicerade svaren på klinisk elektrokemoterapi för varje specifik typ av tumör och uppskattar fraktioneringsviktsresponsen från uppgifterna i varje publicerad rapport. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/dd19cced-4c72-4f74-a954-1bca341adb3c
- author
- Persson, Bertil R LU
- organization
- alternative title
- Kapitel 6 Kliniska Studier av EpECT med Bleomycin eller Cis.Platin
- publishing date
- 2018-05-10
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Electro-chemotherapy for, primary skin cancer, Breast Cancer, Bleomycin, Cis-platinum, objective response, weighting response
- host publication
- Electro-Pulse-Enhanced-Chemo-Therapy
- series title
- Acta Scientiarum Lundensia
- editor
- Persson, Bertil R
- volume
- 2018
- pages
- 57 pages
- publisher
- Medical Radiation Physics, Lund University
- ISSN
- 1651-5013
- language
- English
- LU publication?
- yes
- additional info
- In recent years several authors have reviewed the clinical results of Electro Enhanced Chemotherapy: • Electro-chemotherapy for primary skin cancer and skin metastasis related to other malignancies (Reinhold, 2011). • Utility of electro-chemotherapy in melanoma treatment (Testori et al., 2012). • Antitumor effectiveness of electro-chemotherapy: A systematic review and meta-analysis (Mali et al., 2013). • Electro-chemotherapy in Breast Cancer: A Review of References (Schmidt et al., 2014). • Treatments of advanced basal cell carcinoma: a review of the literature" (Peris et al., 2016). • Treatment efficacy with electro-chemotherapy: A multi-institutional prospective observational study on 376 patients with superficial tumours"(Campana et al., 2016b). • Basal cell carcinoma: 10-year experience with electro-chemotherapy (Campana et al., 2017b). • Electro-chemotherapy in Breast Cancer - Discussion of the Method and Literature Review (Wichtowski et al., 2017). The treatment results are in most cases reported in terms of following quantities where the fractional response = (No. cases with the actual response / Total No. Cases) CR = Complete response; PR = partial response; SD = stable disease; PD = progressive disease; OR = objective response; CR = fractional complete response; PR = fractional partial response; SD = fractional stable disease; PD = fractional progressive disease; OR = fractional objective response Usually the sum of complete and partial responses called Objective Response (OR = CR + PR) is used as a general quantity for the response of the treatment in question without considering the responses of stable and progress disease. In order to be able unify all four quantities into a quantity which consider the total response a quantity named “fractional weighting response”, WR is defined as follow: In order to estimate the response considering all four response quantities a quantity named “fractional weighted response”, WR is defined as follow: WR = (3OR + 1PR + 0SD - 3PR)/3; This chapter summarize the published responses of clinical electro-chemotherapy for each specific type of tumour, and estimate the fractional weighting response from the data of each published report.
- id
- dd19cced-4c72-4f74-a954-1bca341adb3c
- date added to LUP
- 2018-05-12 21:23:58
- date last changed
- 2020-08-10 16:15:16
@inbook{dd19cced-4c72-4f74-a954-1bca341adb3c, abstract = {{In recent years several authors have reviewed the clinical results of Electro Enhanced Chemotherapy: <br/>• Electro-chemotherapy for primary skin cancer and skin metastasis related to other malignancies (Reinhold, 2011). <br/>• Utility of electro-chemotherapy in melanoma treatment (Testori et al., 2012).<br/>• Antitumor effectiveness of electro-chemotherapy: A systematic review and meta-analysis (Mali et al., 2013).<br/>• Electro-chemotherapy in Breast Cancer: A Review of References (Schmidt et al., 2014).<br/>• Treatments of advanced basal cell carcinoma: a review of the literature" (Peris et al., 2016).<br/>• Treatment efficacy with electro-chemotherapy: A multi-institutional prospective observational study on 376 patients with superficial tumours"(Campana et al., 2016b).<br/>• Basal cell carcinoma: 10-year experience with electro-chemotherapy (Campana et al., 2017b).<br/>• Electro-chemotherapy in Breast Cancer - Discussion of the Method and Literature Review (Wichtowski et al., 2017).<br/> <br/>The treatment results are in most cases reported in terms of following quantities where the fractional response <br/> = (No. cases with the actual response / Total No. Cases)<br/><br/> CR = Complete response; <br/>PR = partial response; <br/>SD = stable disease; <br/>PD = progressive disease; <br/>OR = objective response; CR = fractional complete response; <br/>PR = fractional partial response; <br/>SD = fractional stable disease; <br/>PD = fractional progressive disease; <br/>OR = fractional objective response<br/><br/>Usually the sum of complete and partial responses called Objective Response (OR = CR + PR) is used as a general quantity for the response of the treatment in question without considering the responses of stable and progress disease.<br/>In order to be able unify all four quantities into a quantity which consider the total response a quantity named “fractional weighting response”, WR is defined as follow:<br/>In order to estimate the response considering all four response quantities a quantity named “fractional weighted response”, WR is defined as follow:<br/>WR = (3OR + 1PR + 0SD - 3PR)/3;<br/>The following sections summarize the published responses of clinical electro-chemotherapy for each specific type of tumour, and estimate the fractional weighting response from the data of each published report. <br/>}}, author = {{Persson, Bertil R}}, booktitle = {{Electro-Pulse-Enhanced-Chemo-Therapy}}, editor = {{Persson, Bertil R}}, issn = {{1651-5013}}, keywords = {{Electro-chemotherapy for; primary skin cancer; Breast Cancer; Bleomycin; Cis-platinum; objective response; weighting response}}, language = {{eng}}, month = {{05}}, pages = {{1--1}}, publisher = {{Medical Radiation Physics, Lund University}}, series = {{Acta Scientiarum Lundensia}}, title = {{Clinical Studies of EpECT with Bleomycin or Cis-Platin}}, volume = {{2018}}, year = {{2018}}, }