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Clinical Studies of EpECT with Bleomycin or Cis-Platin

Persson, Bertil R LU (2018) In Electro-Pulse-Enhanced-Chemo-Therapy 2018. p.1-1
Abstract (Swedish)
Under de senaste åren har flera författare granskat de kliniska resultaten av Electro Enhanced Chemotherapy:
• Elektrokemoterapi för primär hudcancer och hudmetastas i samband med andra maligniteter (Reinhold, 2011).
• Utnyttjande av elektrokemoterapi vid behandling av melanom (Testori et al., 2012).
• Antitumörverkan av elektrokemoterapi: En systematisk granskning och meta-analys (Mali et al., 2013).
• Elektrokemoterapi i bröstcancer: En översyn av referenser (Schmidt et al., 2014).
• Behandlingar av avancerat basalcellkarcinom: en genomgång av litteraturen "(Peris et al., 2016).
• Behandlingseffektivitet med elektrokemoterapi: En multinationell prospektiv observationsstudie på 376 patienter med ytliga tumörer... (More)
Under de senaste åren har flera författare granskat de kliniska resultaten av Electro Enhanced Chemotherapy:
• Elektrokemoterapi för primär hudcancer och hudmetastas i samband med andra maligniteter (Reinhold, 2011).
• Utnyttjande av elektrokemoterapi vid behandling av melanom (Testori et al., 2012).
• Antitumörverkan av elektrokemoterapi: En systematisk granskning och meta-analys (Mali et al., 2013).
• Elektrokemoterapi i bröstcancer: En översyn av referenser (Schmidt et al., 2014).
• Behandlingar av avancerat basalcellkarcinom: en genomgång av litteraturen "(Peris et al., 2016).
• Behandlingseffektivitet med elektrokemoterapi: En multinationell prospektiv observationsstudie på 376 patienter med ytliga tumörer "(Campana et al., 2016b).
• Basalcellkarcinom: 10 års erfarenhet av elektrokemoterapi (Campana et al., 2017b).
• Elektrokemoterapi i bröstcancer - Diskussion om Metod och litteraturgranskning (Wichtowski et al., 2017).

Behandlingsresultaten rapporteras i de flesta fall med avseende på följande kvantiteter där fraktionellt svar
 = (Antal fall med det faktiska svaret / Totalt antal fall)

CR = komplett svar;
PR = partiell respons;
SD = stabil sjukdom;
PD = progressiv sjukdom;
OR = objektivt svar CR = fraktionalt komplett svar;
PR = fraktionellt partiellt svar
SD = fraktionell stabil sjukdom;
PD = fraktionell progressiv sjukdom;
OR = fraktionellt objektivt svar

Vanligtvis används summan av fullständiga och partiella svar som kallas målrespons (OR = CR + PR) som en allmän kvantitet för svaret på behandlingen i fråga utan att överväga svaren på stabil och framstegssjukdom.
För att kunna kombinera alla fyra kvantiteterna i en kvantitet som anser det totala svaret en kvantitet som heter "fraktionellt viktningssvar" definieras WR som följer:
För att uppskatta svaret med tanke på alla fyra svarkvantiteterna definieras en kvantitet som heter "fraktionerad viktad respons", enligt följande:
WR = (3OR + 1PR + 0SD - 3PR) / 3;
I det här kapitlet sammanfattas de publicerade svaren på klinisk elektrokemoterapi för varje specifik typ av tumör och uppskattar fraktioneringsviktsresponsen från uppgifterna i varje publicerad rapport. (Less)
Abstract
In recent years several authors have reviewed the clinical results of Electro Enhanced Chemotherapy:
• Electro-chemotherapy for primary skin cancer and skin metastasis related to other malignancies (Reinhold, 2011).
• Utility of electro-chemotherapy in melanoma treatment (Testori et al., 2012).
• Antitumor effectiveness of electro-chemotherapy: A systematic review and meta-analysis (Mali et al., 2013).
• Electro-chemotherapy in Breast Cancer: A Review of References (Schmidt et al., 2014).
• Treatments of advanced basal cell carcinoma: a review of the literature" (Peris et al., 2016).
• Treatment efficacy with electro-chemotherapy: A multi-institutional prospective observational study on 376 patients with... (More)
In recent years several authors have reviewed the clinical results of Electro Enhanced Chemotherapy:
• Electro-chemotherapy for primary skin cancer and skin metastasis related to other malignancies (Reinhold, 2011).
• Utility of electro-chemotherapy in melanoma treatment (Testori et al., 2012).
• Antitumor effectiveness of electro-chemotherapy: A systematic review and meta-analysis (Mali et al., 2013).
• Electro-chemotherapy in Breast Cancer: A Review of References (Schmidt et al., 2014).
• Treatments of advanced basal cell carcinoma: a review of the literature" (Peris et al., 2016).
• Treatment efficacy with electro-chemotherapy: A multi-institutional prospective observational study on 376 patients with superficial tumours"(Campana et al., 2016b).
• Basal cell carcinoma: 10-year experience with electro-chemotherapy (Campana et al., 2017b).
• Electro-chemotherapy in Breast Cancer - Discussion of the Method and Literature Review (Wichtowski et al., 2017).

The treatment results are in most cases reported in terms of following quantities where the fractional response
 = (No. cases with the actual response / Total No. Cases)

CR = Complete response;
PR = partial response;
SD = stable disease;
PD = progressive disease;
OR = objective response; CR = fractional complete response;
PR = fractional partial response;
SD = fractional stable disease;
PD = fractional progressive disease;
OR = fractional objective response

Usually the sum of complete and partial responses called Objective Response (OR = CR + PR) is used as a general quantity for the response of the treatment in question without considering the responses of stable and progress disease.
In order to be able unify all four quantities into a quantity which consider the total response a quantity named “fractional weighting response”, WR is defined as follow:
In order to estimate the response considering all four response quantities a quantity named “fractional weighted response”, WR is defined as follow:
WR = (3OR + 1PR + 0SD - 3PR)/3;
The following sections summarize the published responses of clinical electro-chemotherapy for each specific type of tumour, and estimate the fractional weighting response from the data of each published report.
(Less)
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author
organization
alternative title
Kapitel 6 Kliniska Studier av EpECT med Bleomycin eller Cis.Platin
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
epub
subject
keywords
Electro-chemotherapy for, primary skin cancer, Breast Cancer, Bleomycin, Cis-platinum, objective response, weighting response
in
Electro-Pulse-Enhanced-Chemo-Therapy
editor
Persson, Bertil R and
volume
2018
pages
57 pages
publisher
Acta Scientiarum Lundensia, ISSN 1651-5013
language
English
LU publication?
yes
id
dd19cced-4c72-4f74-a954-1bca341adb3c
date added to LUP
2018-05-12 21:23:58
date last changed
2018-09-17 09:46:16
@inbook{dd19cced-4c72-4f74-a954-1bca341adb3c,
  abstract     = {In recent years several authors have reviewed the clinical results of Electro Enhanced Chemotherapy:    <br/>•	Electro-chemotherapy for primary skin cancer and skin metastasis related to other malignancies (Reinhold, 2011).  <br/>•	Utility of electro-chemotherapy in melanoma treatment (Testori et al., 2012).<br/>•	Antitumor effectiveness of electro-chemotherapy: A systematic review and meta-analysis  (Mali et al., 2013).<br/>•	Electro-chemotherapy in Breast Cancer: A Review of References (Schmidt et al., 2014).<br/>•	Treatments of advanced basal cell carcinoma: a review of the literature" (Peris et al., 2016).<br/>•	Treatment efficacy with electro-chemotherapy: A multi-institutional prospective observational study on 376 patients with superficial tumours"(Campana et al., 2016b).<br/>•	Basal cell carcinoma: 10-year experience with electro-chemotherapy (Campana et al., 2017b).<br/>•	Electro-chemotherapy in Breast Cancer - Discussion of the Method and Literature Review (Wichtowski et al., 2017).<br/>  <br/>The treatment results are in most cases reported in terms of following quantities where the fractional response <br/> = (No. cases with the actual response / Total No. Cases)<br/><br/>	CR = Complete response; <br/>PR = partial response; <br/>SD = stable disease; <br/>PD = progressive disease; <br/>OR = objective response;	CR = fractional complete response;  <br/>PR = fractional partial response; <br/>SD = fractional stable disease; <br/>PD = fractional progressive disease; <br/>OR = fractional objective response<br/><br/>Usually the sum of complete and partial responses called Objective Response (OR = CR + PR) is used as a general quantity for the response of the treatment in question without considering the responses of stable and progress disease.<br/>In order to be able unify all four quantities into a quantity which consider the total response a quantity named “fractional weighting response”, WR is defined as follow:<br/>In order to estimate the response considering all four response quantities a quantity named  “fractional weighted response”, WR is defined as follow:<br/>WR = (3OR   + 1PR + 0SD - 3PR)/3;<br/>The following sections summarize the published   responses of clinical electro-chemotherapy for each specific type of tumour, and estimate the  fractional weighting response from the data of each published report. <br/>},
  author       = {Persson, Bertil R},
  booktitle    = {Kapitel 6 Kliniska Studier av EpECT med Bleomycin eller Cis.Platin},
  editor       = {Persson, Bertil R},
  keyword      = {Electro-chemotherapy for,primary skin cancer,Breast Cancer,Bleomycin,Cis-platinum,objective response,weighting response},
  language     = {eng},
  month        = {05},
  pages        = {1--1},
  publisher    = {Acta Scientiarum Lundensia,   ISSN  1651-5013},
  series       = {Electro-Pulse-Enhanced-Chemo-Therapy  },
  title        = {Clinical Studies of EpECT with Bleomycin or Cis-Platin},
  volume       = {2018},
  year         = {2018},
}