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Autoimmunity of diabetes

Lernmark, A. LU ; Barmeier, H. ; Dube, S. ; Hagopian, W. ; Karlsen, A. and Wassmuth, R. (1991) In Endocrinology and Metabolism Clinics of North America 20(3).
Abstract

Mechanisms underlying the etiology and pathogenesis of insulin-dependent diabetes mellitus (IDDM) are reviewed. Its natural history and associated autoimmune phenomena indicate that IDDM is a systemic disorder resulting in a specific disappearance of pancreatic β cells. Genetic aspects of the disorder include its linkage to HLA class II gene loci, although the manner in which this produces autoimmunity is unclear, and a second gene outside the HLA complex could be more important. The roles of environmental influences, including viruses, also require clarification. Further studies on the molecular biology of the immune response against β cell specific antigens are required.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Endocrinology and Metabolism Clinics of North America
volume
20
issue
3
publisher
W.B. Saunders Ltd
external identifiers
  • scopus:0025741818
  • pmid:1935920
ISSN
0889-8529
DOI
10.1016/S0889-8529(18)30260-3
language
English
LU publication?
no
id
dd23c1c0-9ff5-4814-a0e7-445c06dcc9dd
date added to LUP
2019-09-11 09:40:55
date last changed
2020-01-13 02:21:09
@article{dd23c1c0-9ff5-4814-a0e7-445c06dcc9dd,
  abstract     = {<p>Mechanisms underlying the etiology and pathogenesis of insulin-dependent diabetes mellitus (IDDM) are reviewed. Its natural history and associated autoimmune phenomena indicate that IDDM is a systemic disorder resulting in a specific disappearance of pancreatic β cells. Genetic aspects of the disorder include its linkage to HLA class II gene loci, although the manner in which this produces autoimmunity is unclear, and a second gene outside the HLA complex could be more important. The roles of environmental influences, including viruses, also require clarification. Further studies on the molecular biology of the immune response against β cell specific antigens are required.</p>},
  author       = {Lernmark, A. and Barmeier, H. and Dube, S. and Hagopian, W. and Karlsen, A. and Wassmuth, R.},
  issn         = {0889-8529},
  language     = {eng},
  month        = {09},
  number       = {3},
  publisher    = {W.B. Saunders Ltd},
  series       = {Endocrinology and Metabolism Clinics of North America},
  title        = {Autoimmunity of diabetes},
  url          = {http://dx.doi.org/10.1016/S0889-8529(18)30260-3},
  doi          = {10.1016/S0889-8529(18)30260-3},
  volume       = {20},
  year         = {1991},
}