Modelling intra-muscular contraction dynamics using in silico to in vivo domain translation
Ali, Hazrat ; Umander, Johannes ; Rohlén, Robin LU
; Röhrle, Oliver
and Grönlund, Christer
(2022)
In BioMedical Engineering Online
21(1).
- Abstract
Background: Advances in sports medicine, rehabilitation applications and diagnostics of neuromuscular disorders are based on the analysis of skeletal muscle contractions. Recently, medical imaging techniques have transformed the study of muscle contractions, by allowing identification of individual motor units’ activity, within the whole studied muscle. However, appropriate image-based simulation models, which would assist the continued development of these new imaging methods are missing. This is mainly due to a lack of models that describe the complex interaction between tissues within a muscle and its surroundings, e.g., muscle fibres, fascia, vasculature, bone, skin, and subcutaneous fat. Herein, we propose a new approach to... (More)
Background: Advances in sports medicine, rehabilitation applications and diagnostics of neuromuscular disorders are based on the analysis of skeletal muscle contractions. Recently, medical imaging techniques have transformed the study of muscle contractions, by allowing identification of individual motor units’ activity, within the whole studied muscle. However, appropriate image-based simulation models, which would assist the continued development of these new imaging methods are missing. This is mainly due to a lack of models that describe the complex interaction between tissues within a muscle and its surroundings, e.g., muscle fibres, fascia, vasculature, bone, skin, and subcutaneous fat. Herein, we propose a new approach to overcome this limitation. Methods: In this work, we propose to use deep learning to model the authentic intra-muscular skeletal muscle contraction pattern using domain-to-domain translation between in silico (simulated) and in vivo (experimental) image sequences of skeletal muscle contraction dynamics. For this purpose, the 3D cycle generative adversarial network (cycleGAN) models were evaluated on several hyperparameter settings and modifications. The results show that there were large differences between the spatial features of in silico and in vivo data, and that a model could be trained to generate authentic spatio-temporal features similar to those obtained from in vivo experimental data. In addition, we used difference maps between input and output of the trained model generator to study the translated characteristics of in vivo data. Results: This work provides a model to generate authentic intra-muscular skeletal muscle contraction dynamics that could be used to gain further and much needed physiological and pathological insights and assess and overcome limitations within the newly developed research field of neuromuscular imaging.
(Less)
- author
- Ali, Hazrat
; Umander, Johannes
; Rohlén, Robin
LU
; Röhrle, Oliver
and Grönlund, Christer
- publishing date
- 2022-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Domain adaptation, Fascia, Generative adversarial network, High frame rate imaging, Neural networks, Noise adaptation, Plane wave, Simulation model, Skeletal muscle, Ultrasound
- in
- BioMedical Engineering Online
- volume
- 21
- issue
- 1
- article number
- 46
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:35804415
- scopus:85133706924
- ISSN
- 1475-925X
- DOI
- 10.1186/s12938-022-01016-4
- language
- English
- LU publication?
- no
- additional info
- Funding Information: Open access funding provided by Umea University. This work was supported by the Kempe Foundations (SMK-1868) and the Swedish Research Council (2015-04461). Publisher Copyright: © 2022, The Author(s).
- id
- dd27a9ef-8dfa-4043-84b3-aa0338a3b7e5
- date added to LUP
- 2023-05-15 23:58:15
- date last changed
- 2024-04-19 22:50:15
@article{dd27a9ef-8dfa-4043-84b3-aa0338a3b7e5,
abstract = {{<p>Background: Advances in sports medicine, rehabilitation applications and diagnostics of neuromuscular disorders are based on the analysis of skeletal muscle contractions. Recently, medical imaging techniques have transformed the study of muscle contractions, by allowing identification of individual motor units’ activity, within the whole studied muscle. However, appropriate image-based simulation models, which would assist the continued development of these new imaging methods are missing. This is mainly due to a lack of models that describe the complex interaction between tissues within a muscle and its surroundings, e.g., muscle fibres, fascia, vasculature, bone, skin, and subcutaneous fat. Herein, we propose a new approach to overcome this limitation. Methods: In this work, we propose to use deep learning to model the authentic intra-muscular skeletal muscle contraction pattern using domain-to-domain translation between in silico (simulated) and in vivo (experimental) image sequences of skeletal muscle contraction dynamics. For this purpose, the 3D cycle generative adversarial network (cycleGAN) models were evaluated on several hyperparameter settings and modifications. The results show that there were large differences between the spatial features of in silico and in vivo data, and that a model could be trained to generate authentic spatio-temporal features similar to those obtained from in vivo experimental data. In addition, we used difference maps between input and output of the trained model generator to study the translated characteristics of in vivo data. Results: This work provides a model to generate authentic intra-muscular skeletal muscle contraction dynamics that could be used to gain further and much needed physiological and pathological insights and assess and overcome limitations within the newly developed research field of neuromuscular imaging.</p>}},
author = {{Ali, Hazrat and Umander, Johannes and Rohlén, Robin and Röhrle, Oliver and Grönlund, Christer}},
issn = {{1475-925X}},
keywords = {{Domain adaptation; Fascia; Generative adversarial network; High frame rate imaging; Neural networks; Noise adaptation; Plane wave; Simulation model; Skeletal muscle; Ultrasound}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BioMedical Engineering Online}},
title = {{Modelling intra-muscular contraction dynamics using in silico to in vivo domain translation}},
url = {{http://dx.doi.org/10.1186/s12938-022-01016-4}},
doi = {{10.1186/s12938-022-01016-4}},
volume = {{21}},
year = {{2022}},
}