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The gene of the protease inhibitor SKALP/elafin is a member of the REST gene family

Lundwall, Åke LU and Ulvsback, Magnus (1996) In Biochem Biophys Res Commun 221(2). p.7-323
Abstract
Members of the REST gene family characteristically have a transcription unit consisting of three exons. The first and the last exon are conserved among members, while the second exon--encoding almost all of the mature protein--differs considerably. The so far known REST genes are highly, and almost exclusively, expressed in the seminal vesicles. By sequence analysis we have now identified the gene for the protease inhibitor SKALP/elafin as a new member of the REST gene family. The protein is expressed in the epidermis and serves, like the product of several REST genes, as substrate for transglutaminase. We have also found what seems to be a locus encompassing both transglutaminases and REST genes centered around the region q12 on the human... (More)
Members of the REST gene family characteristically have a transcription unit consisting of three exons. The first and the last exon are conserved among members, while the second exon--encoding almost all of the mature protein--differs considerably. The so far known REST genes are highly, and almost exclusively, expressed in the seminal vesicles. By sequence analysis we have now identified the gene for the protease inhibitor SKALP/elafin as a new member of the REST gene family. The protein is expressed in the epidermis and serves, like the product of several REST genes, as substrate for transglutaminase. We have also found what seems to be a locus encompassing both transglutaminases and REST genes centered around the region q12 on the human chromosome 20, raising the question whether the enzymes and substrates have evolved in parallel. (Less)
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publication status
published
subject
keywords
Proteins/*genetics, *Multigene Family, Molecular Sequence Data, Humans, Complementary, DNA, Animals, Base Sequence, Research Support, Non-U.S. Gov't, Sequence Homology, Nucleic Acid, Serine Proteinase Inhibitors/*genetics
in
Biochem Biophys Res Commun
volume
221
issue
2
pages
7 - 323
publisher
Elsevier
external identifiers
  • scopus:0343867207
language
English
LU publication?
yes
additional info
2
id
dd371cfd-82ba-465c-a74e-04580ad3daa5 (old id 3965251)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8619854
date added to LUP
2016-04-04 14:32:32
date last changed
2022-05-02 01:54:12
@article{dd371cfd-82ba-465c-a74e-04580ad3daa5,
  abstract     = {{Members of the REST gene family characteristically have a transcription unit consisting of three exons. The first and the last exon are conserved among members, while the second exon--encoding almost all of the mature protein--differs considerably. The so far known REST genes are highly, and almost exclusively, expressed in the seminal vesicles. By sequence analysis we have now identified the gene for the protease inhibitor SKALP/elafin as a new member of the REST gene family. The protein is expressed in the epidermis and serves, like the product of several REST genes, as substrate for transglutaminase. We have also found what seems to be a locus encompassing both transglutaminases and REST genes centered around the region q12 on the human chromosome 20, raising the question whether the enzymes and substrates have evolved in parallel.}},
  author       = {{Lundwall, Åke and Ulvsback, Magnus}},
  keywords     = {{Proteins/*genetics; *Multigene Family; Molecular Sequence Data; Humans; Complementary; DNA; Animals; Base Sequence; Research Support; Non-U.S. Gov't; Sequence Homology; Nucleic Acid; Serine Proteinase Inhibitors/*genetics}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{7--323}},
  publisher    = {{Elsevier}},
  series       = {{Biochem Biophys Res Commun}},
  title        = {{The gene of the protease inhibitor SKALP/elafin is a member of the REST gene family}},
  url          = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8619854}},
  volume       = {{221}},
  year         = {{1996}},
}