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Metastases from Renal Cell Carcinoma. Recurrence Patterns, Detection and Management.

Dabestani, Saeed LU (2018) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2018(19).
Abstract
This thesis provides novel insights into the detection, recurrence patterns and management of metastases from renal cell carcinoma (RCC). In paper I the role of metastasectomy and other local therapies were clarified in a robust systematic review. Studies included showed a benefit in performing complete metastasectomy in terms of overall survival (OS) and cancer-specific survival (CSS). Some evidence suggested benefits in reaching local or symptomatic control of metastases using radiotherapy. Evidence quality was low with overall high risk of bias and confounding. In paper II a population-based cohort was presented in regards to RCC demographics and treatments. Incidence of primary metastatic RCC decreased from 2005 (23%) to 2009 (18%).... (More)
This thesis provides novel insights into the detection, recurrence patterns and management of metastases from renal cell carcinoma (RCC). In paper I the role of metastasectomy and other local therapies were clarified in a robust systematic review. Studies included showed a benefit in performing complete metastasectomy in terms of overall survival (OS) and cancer-specific survival (CSS). Some evidence suggested benefits in reaching local or symptomatic control of metastases using radiotherapy. Evidence quality was low with overall high risk of bias and confounding. In paper II a population-based cohort was presented in regards to RCC demographics and treatments. Incidence of primary metastatic RCC decreased from 2005 (23%) to 2009 (18%). Treatments for asynchronous recurrences were shown to be systemic in 50%, observational in 27% and metastasectomy in 17% (68% with curative intent). For Study III and IV a multinational database (RECUR) with non-metastatic RCC patients was established to provide evidence on the impact of follow-up on recurrence detection and survival. In study III analysing clear cell RCC recurrence patterns and survival, the low-risk group recurrences according to Leibovich score were found to be infrequent at follow-up and occurred later. OS after recurrence management was disappointing especially in the Leibovich score high-risk group which harbored most patients with potentially curable recurrences. Symptomatic at recurrence meant poorer survival irrespective of metastatic burden. Competing risk analysis suggested age as an important factor in follow-up protocols. In paper IV imaging modality (cross-sectional vs. conventional) and more frequent follow-up imaging for detection of RCC recurrences did not impact OS. Finally, use of excessive follow-up imaging compared to frequencies recommended by the EAU guidelines was unlikely to increase OS after recurrence. Higher level of evidence is needed as well as novel markers in the molecular era of RCC to develop better follow-up protocols and prognostic models. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • professor Lund, Lars, Odense University Hospital
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Renal Cell Carcinoma, Follow-up, Recurrence, Metastasectomy, Local Therapy, Survival, Renal Cell Carcinoma, Follow-up, Surveillance, Recurrence, Metastasectomy, Local Therapy, Survival
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2018
issue
19
pages
90 pages
publisher
Lund University: Faculty of Medicine
defense location
Lilla aulan, Jan Waldenströms gata 5, Skånes Universitetssjukhus i Malmö
defense date
2018-05-22 13:00:00
external identifiers
  • scopus:85039779433
ISSN
1652-8220
ISBN
978-91-7619-586-4
language
English
LU publication?
yes
additional info
ISSN: 1652-8220 Lund University, Faculty of Medicine Doctoral Dissertation Series 2018:19
id
dd5c926f-0464-49d7-a625-8ae857c648d3
date added to LUP
2018-01-09 18:16:04
date last changed
2020-06-03 04:14:24
@phdthesis{dd5c926f-0464-49d7-a625-8ae857c648d3,
  abstract     = {This thesis provides novel insights into the detection, recurrence patterns and management of metastases from renal cell carcinoma (RCC). In paper I the role of metastasectomy and other local therapies were clarified in a robust systematic review. Studies included showed a benefit in performing complete metastasectomy in terms of overall survival (OS) and cancer-specific survival (CSS). Some evidence suggested benefits in reaching local or symptomatic control of metastases using radiotherapy. Evidence quality was low with overall high risk of bias and confounding. In paper II a population-based cohort was presented in regards to RCC demographics and treatments. Incidence of primary metastatic RCC decreased from 2005 (23%) to 2009 (18%). Treatments for asynchronous recurrences were shown to be systemic in 50%, observational in 27% and metastasectomy in 17% (68% with curative intent). For Study III and IV a multinational database (RECUR) with non-metastatic RCC patients was established to provide evidence on the impact of follow-up on recurrence detection and survival. In study III analysing clear cell RCC recurrence patterns and survival, the low-risk group recurrences according to Leibovich score were found to be infrequent at follow-up and occurred later. OS after recurrence management was disappointing especially in the Leibovich score high-risk group which harbored most patients with potentially curable recurrences. Symptomatic at recurrence meant poorer survival irrespective of metastatic burden. Competing risk analysis suggested age as an important factor in follow-up protocols. In paper IV imaging modality (cross-sectional vs. conventional) and more frequent follow-up imaging for detection of RCC recurrences did not impact OS. Finally, use of excessive follow-up imaging compared to frequencies recommended by the EAU guidelines was unlikely to increase OS after recurrence. Higher level of evidence is needed as well as novel markers in the molecular era of RCC to develop better follow-up protocols and prognostic models.},
  author       = {Dabestani, Saeed},
  isbn         = {978-91-7619-586-4},
  issn         = {1652-8220},
  language     = {eng},
  number       = {19},
  publisher    = {Lund University: Faculty of Medicine},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series},
  title        = {Metastases from Renal Cell Carcinoma. Recurrence Patterns, Detection and Management.},
  url          = {https://lup.lub.lu.se/search/ws/files/41603304/Dabestani_S_PhD_thesis_22_May_2018_Webb.pdf},
  volume       = {2018},
  year         = {2018},
}