HLA class II is associated with the frequency of glutamic acid decarboxylase M(r) 65,000 autoantibodies in Japanese patients with insulin dependent diabetes mellitus
Kasuga, A. ; Falorni, A. ; Maruyama, T. ; Ozawa, Y. ; Grubin, C. E. ; Matsubara, K. ; Takei, I. ; Saruta, T. ; Scheynius, A. and Lernmark, Å LU
(1996)
In Acta Diabetologica
33(2).
p.108-113
- Abstract
Autoantibodies to glutamic acid decarboxylase (GAD65Ab) are common in both caucasian and Japanese patients with insulin-dependent diabetes mellitus (type 1), while the type 1-associated HLA haplotypes differ. In the present study, we analyzed GAD65Ab in relation to HLA-DQ and -DR alleles in Japanese type 1 patients. GAD65Ab were found in 58% short-duration (less than 5 years) type 1, 23% long-duration type 1, 56% slowly progressive type 1, 3% type 2 patients, and 1.7% healthy individuals. In 75 HLA-typed type 1 patients, the GAD65Ab frequency was higher in short-duration patients with DRB1(*)08 allele (100%, Pc < 0.05). GAD65Ab frequencies in DQB1(*)0302, DQB1(*)0303, and DRB1(*)09-positive, long-duration type 1 patients were lower... (More)
Autoantibodies to glutamic acid decarboxylase (GAD65Ab) are common in both caucasian and Japanese patients with insulin-dependent diabetes mellitus (type 1), while the type 1-associated HLA haplotypes differ. In the present study, we analyzed GAD65Ab in relation to HLA-DQ and -DR alleles in Japanese type 1 patients. GAD65Ab were found in 58% short-duration (less than 5 years) type 1, 23% long-duration type 1, 56% slowly progressive type 1, 3% type 2 patients, and 1.7% healthy individuals. In 75 HLA-typed type 1 patients, the GAD65Ab frequency was higher in short-duration patients with DRB1(*)08 allele (100%, Pc < 0.05). GAD65Ab frequencies in DQB1(*)0302, DQB1(*)0303, and DRB1(*)09-positive, long-duration type 1 patients were lower than those in short-duration type 1 patients (14%, 19%, and 20%, Pc < 0.02 compared with short-duration type 1, 90%, 75%, and 71%, respectively), while the frequency varied less in DQB1(*)04 individuals (44% and 30% in short- and long-duration type 1 patients, respectively). These findings were also observed among patients with DRB1(*)04, i.e., the haplotype DRB1(*)0405-DQB1(*)0401 showed less variation in frequency of GAD65Ab (44% and 35% in short- and long-duration type 1 patients, respectively), while DRB1(*)04xx-DQB1(*)0302 showed lower frequency in long-duration type 1 than short-duration (13% and 100%, respectively), Thus, HLA class II is associated with frequency GAD65Ab, and this association might be affected by disease duration in Japanese type 1 patients.
(Less)
- author
- Kasuga, A.
; Falorni, A.
; Maruyama, T.
; Ozawa, Y.
; Grubin, C. E.
; Matsubara, K.
; Takei, I.
; Saruta, T.
; Scheynius, A.
and Lernmark, Å
LU
- publishing date
- 1996-01-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Autoantigen, Autoimmunity, Human leukocyte antigen, Insulin-dependent diabetes mellitus
- in
- Acta Diabetologica
- volume
- 33
- issue
- 2
- pages
- 108 - 113
- publisher
- Springer
- external identifiers
-
- scopus:9444231788
- pmid:8870811
- ISSN
- 0940-5429
- DOI
- 10.1007/BF00569419
- language
- English
- LU publication?
- no
- id
- dd7638c0-8e64-4e88-a756-e45dfb74d3cb
- date added to LUP
- 2019-07-01 13:19:34
- date last changed
- 2024-03-13 08:19:39
@article{dd7638c0-8e64-4e88-a756-e45dfb74d3cb,
abstract = {{<p>Autoantibodies to glutamic acid decarboxylase (GAD65Ab) are common in both caucasian and Japanese patients with insulin-dependent diabetes mellitus (type 1), while the type 1-associated HLA haplotypes differ. In the present study, we analyzed GAD65Ab in relation to HLA-DQ and -DR alleles in Japanese type 1 patients. GAD65Ab were found in 58% short-duration (less than 5 years) type 1, 23% long-duration type 1, 56% slowly progressive type 1, 3% type 2 patients, and 1.7% healthy individuals. In 75 HLA-typed type 1 patients, the GAD65Ab frequency was higher in short-duration patients with DRB1(*)08 allele (100%, Pc < 0.05). GAD65Ab frequencies in DQB1(*)0302, DQB1(*)0303, and DRB1(*)09-positive, long-duration type 1 patients were lower than those in short-duration type 1 patients (14%, 19%, and 20%, Pc < 0.02 compared with short-duration type 1, 90%, 75%, and 71%, respectively), while the frequency varied less in DQB1(*)04 individuals (44% and 30% in short- and long-duration type 1 patients, respectively). These findings were also observed among patients with DRB1(*)04, i.e., the haplotype DRB1(*)0405-DQB1(*)0401 showed less variation in frequency of GAD65Ab (44% and 35% in short- and long-duration type 1 patients, respectively), while DRB1(*)04xx-DQB1(*)0302 showed lower frequency in long-duration type 1 than short-duration (13% and 100%, respectively), Thus, HLA class II is associated with frequency GAD65Ab, and this association might be affected by disease duration in Japanese type 1 patients.</p>}},
author = {{Kasuga, A. and Falorni, A. and Maruyama, T. and Ozawa, Y. and Grubin, C. E. and Matsubara, K. and Takei, I. and Saruta, T. and Scheynius, A. and Lernmark, Å}},
issn = {{0940-5429}},
keywords = {{Autoantigen; Autoimmunity; Human leukocyte antigen; Insulin-dependent diabetes mellitus}},
language = {{eng}},
month = {{01}},
number = {{2}},
pages = {{108--113}},
publisher = {{Springer}},
series = {{Acta Diabetologica}},
title = {{HLA class II is associated with the frequency of glutamic acid decarboxylase M(r) 65,000 autoantibodies in Japanese patients with insulin dependent diabetes mellitus}},
url = {{http://dx.doi.org/10.1007/BF00569419}},
doi = {{10.1007/BF00569419}},
volume = {{33}},
year = {{1996}},
}