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HLA class II is associated with the frequency of glutamic acid decarboxylase M(r) 65,000 autoantibodies in Japanese patients with insulin dependent diabetes mellitus

Kasuga, A. ; Falorni, A. ; Maruyama, T. ; Ozawa, Y. ; Grubin, C. E. ; Matsubara, K. ; Takei, I. ; Saruta, T. ; Scheynius, A. and Lernmark, Å LU (1996) In Acta Diabetologica 33(2). p.108-113
Abstract

Autoantibodies to glutamic acid decarboxylase (GAD65Ab) are common in both caucasian and Japanese patients with insulin-dependent diabetes mellitus (type 1), while the type 1-associated HLA haplotypes differ. In the present study, we analyzed GAD65Ab in relation to HLA-DQ and -DR alleles in Japanese type 1 patients. GAD65Ab were found in 58% short-duration (less than 5 years) type 1, 23% long-duration type 1, 56% slowly progressive type 1, 3% type 2 patients, and 1.7% healthy individuals. In 75 HLA-typed type 1 patients, the GAD65Ab frequency was higher in short-duration patients with DRB1(*)08 allele (100%, Pc < 0.05). GAD65Ab frequencies in DQB1(*)0302, DQB1(*)0303, and DRB1(*)09-positive, long-duration type 1 patients were lower... (More)

Autoantibodies to glutamic acid decarboxylase (GAD65Ab) are common in both caucasian and Japanese patients with insulin-dependent diabetes mellitus (type 1), while the type 1-associated HLA haplotypes differ. In the present study, we analyzed GAD65Ab in relation to HLA-DQ and -DR alleles in Japanese type 1 patients. GAD65Ab were found in 58% short-duration (less than 5 years) type 1, 23% long-duration type 1, 56% slowly progressive type 1, 3% type 2 patients, and 1.7% healthy individuals. In 75 HLA-typed type 1 patients, the GAD65Ab frequency was higher in short-duration patients with DRB1(*)08 allele (100%, Pc < 0.05). GAD65Ab frequencies in DQB1(*)0302, DQB1(*)0303, and DRB1(*)09-positive, long-duration type 1 patients were lower than those in short-duration type 1 patients (14%, 19%, and 20%, Pc < 0.02 compared with short-duration type 1, 90%, 75%, and 71%, respectively), while the frequency varied less in DQB1(*)04 individuals (44% and 30% in short- and long-duration type 1 patients, respectively). These findings were also observed among patients with DRB1(*)04, i.e., the haplotype DRB1(*)0405-DQB1(*)0401 showed less variation in frequency of GAD65Ab (44% and 35% in short- and long-duration type 1 patients, respectively), while DRB1(*)04xx-DQB1(*)0302 showed lower frequency in long-duration type 1 than short-duration (13% and 100%, respectively), Thus, HLA class II is associated with frequency GAD65Ab, and this association might be affected by disease duration in Japanese type 1 patients.

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author
; ; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Autoantigen, Autoimmunity, Human leukocyte antigen, Insulin-dependent diabetes mellitus
in
Acta Diabetologica
volume
33
issue
2
pages
108 - 113
publisher
Springer
external identifiers
  • pmid:8870811
  • scopus:9444231788
ISSN
0940-5429
DOI
10.1007/BF00569419
language
English
LU publication?
no
id
dd7638c0-8e64-4e88-a756-e45dfb74d3cb
date added to LUP
2019-07-01 13:19:34
date last changed
2021-02-17 04:49:59
@article{dd7638c0-8e64-4e88-a756-e45dfb74d3cb,
  abstract     = {<p>Autoantibodies to glutamic acid decarboxylase (GAD65Ab) are common in both caucasian and Japanese patients with insulin-dependent diabetes mellitus (type 1), while the type 1-associated HLA haplotypes differ. In the present study, we analyzed GAD65Ab in relation to HLA-DQ and -DR alleles in Japanese type 1 patients. GAD65Ab were found in 58% short-duration (less than 5 years) type 1, 23% long-duration type 1, 56% slowly progressive type 1, 3% type 2 patients, and 1.7% healthy individuals. In 75 HLA-typed type 1 patients, the GAD65Ab frequency was higher in short-duration patients with DRB1(*)08 allele (100%, Pc &lt; 0.05). GAD65Ab frequencies in DQB1(*)0302, DQB1(*)0303, and DRB1(*)09-positive, long-duration type 1 patients were lower than those in short-duration type 1 patients (14%, 19%, and 20%, Pc &lt; 0.02 compared with short-duration type 1, 90%, 75%, and 71%, respectively), while the frequency varied less in DQB1(*)04 individuals (44% and 30% in short- and long-duration type 1 patients, respectively). These findings were also observed among patients with DRB1(*)04, i.e., the haplotype DRB1(*)0405-DQB1(*)0401 showed less variation in frequency of GAD65Ab (44% and 35% in short- and long-duration type 1 patients, respectively), while DRB1(*)04xx-DQB1(*)0302 showed lower frequency in long-duration type 1 than short-duration (13% and 100%, respectively), Thus, HLA class II is associated with frequency GAD65Ab, and this association might be affected by disease duration in Japanese type 1 patients.</p>},
  author       = {Kasuga, A. and Falorni, A. and Maruyama, T. and Ozawa, Y. and Grubin, C. E. and Matsubara, K. and Takei, I. and Saruta, T. and Scheynius, A. and Lernmark, Å},
  issn         = {0940-5429},
  language     = {eng},
  month        = {01},
  number       = {2},
  pages        = {108--113},
  publisher    = {Springer},
  series       = {Acta Diabetologica},
  title        = {HLA class II is associated with the frequency of glutamic acid decarboxylase M(r) 65,000 autoantibodies in Japanese patients with insulin dependent diabetes mellitus},
  url          = {http://dx.doi.org/10.1007/BF00569419},
  doi          = {10.1007/BF00569419},
  volume       = {33},
  year         = {1996},
}