Design of a molecular clock with RNA-mediated regulation
(2014) 2014 53rd IEEE Annual Conference on Decision and Control, CDC 2014 p.4611-4616- Abstract
We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to oscillate for appropriate choices of the parameters. Our design can be built experimentally using RNA aptamers.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ddb91431-8be3-4998-8a5b-e24fba5c125e
- author
- Blanchini, Franco ; Cuba Samaniego, Christian ; Franco, Elisa and Giordano, Giulia LU
- organization
- publishing date
- 2014-12
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Proceedings of the IEEE Conference on Decision and Control
- article number
- 7040109
- pages
- 6 pages
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- conference name
- 2014 53rd IEEE Annual Conference on Decision and Control, CDC 2014
- conference location
- Los Angeles, United States
- conference dates
- 2014-12-15 - 2014-12-17
- external identifiers
-
- scopus:84992254999
- DOI
- 10.1109/CDC.2014.7040109
- language
- English
- LU publication?
- no
- id
- ddb91431-8be3-4998-8a5b-e24fba5c125e
- date added to LUP
- 2016-07-06 15:21:40
- date last changed
- 2022-05-02 04:21:03
@inproceedings{ddb91431-8be3-4998-8a5b-e24fba5c125e, abstract = {{<p>We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to oscillate for appropriate choices of the parameters. Our design can be built experimentally using RNA aptamers.</p>}}, author = {{Blanchini, Franco and Cuba Samaniego, Christian and Franco, Elisa and Giordano, Giulia}}, booktitle = {{Proceedings of the IEEE Conference on Decision and Control}}, language = {{eng}}, pages = {{4611--4616}}, publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}}, title = {{Design of a molecular clock with RNA-mediated regulation}}, url = {{http://dx.doi.org/10.1109/CDC.2014.7040109}}, doi = {{10.1109/CDC.2014.7040109}}, year = {{2014}}, }