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Synthesis of Three-Dimensional Ring Fused Heterocycles by a Selective [4 + 2] Cycloaddition Between Bicyclic Thiazolo 2-Pyridones and Arynes

Sarkar, Souvik ; Singh, Pardeep ; Edin, Simon LU ; Wendt, Ola F. LU and Almqvist, Fredrik (2024) In Journal of Organic Chemistry 89(1). p.731-739
Abstract

A selective [4 + 2] cycloaddition reaction of thiazolo-2-pyridones with arynes has been demonstrated. The developed protocol allows rapid access to highly functionalized, structurally complex thiazolo-fused bridged isoquinolones in high yields, which are susceptible to further late-stage functionalization.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Organic Chemistry
volume
89
issue
1
pages
9 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:38093677
  • scopus:85180992605
ISSN
0022-3263
DOI
10.1021/acs.joc.3c01957
language
English
LU publication?
yes
id
ddccb1b4-0f80-4425-9444-25135210d892
date added to LUP
2024-02-07 11:34:12
date last changed
2024-04-23 18:20:11
@article{ddccb1b4-0f80-4425-9444-25135210d892,
  abstract     = {{<p>A selective [4 + 2] cycloaddition reaction of thiazolo-2-pyridones with arynes has been demonstrated. The developed protocol allows rapid access to highly functionalized, structurally complex thiazolo-fused bridged isoquinolones in high yields, which are susceptible to further late-stage functionalization.</p>}},
  author       = {{Sarkar, Souvik and Singh, Pardeep and Edin, Simon and Wendt, Ola F. and Almqvist, Fredrik}},
  issn         = {{0022-3263}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{731--739}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of Organic Chemistry}},
  title        = {{Synthesis of Three-Dimensional Ring Fused Heterocycles by a Selective [4 + 2] Cycloaddition Between Bicyclic Thiazolo 2-Pyridones and Arynes}},
  url          = {{http://dx.doi.org/10.1021/acs.joc.3c01957}},
  doi          = {{10.1021/acs.joc.3c01957}},
  volume       = {{89}},
  year         = {{2024}},
}