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Contact allergy to fragrance mix I and its components in individuals with photocontact allergy to ketoprofen

Marmgren, Victoria LU ; Mowitz, Martin LU ; Zimerson, Erik LU ; Hindsén, Monica LU and Bruze, Magnus LU (2021) In Contact Dermatitis 85(6). p.660-670
Abstract

BACKGROUND: Contact allergy to fragrance mix I (FM I) is over-represented in patients photoallergic to ketoprofen. The prevalence of contact allergy to two components of FM I, cinnamal and cinnamyl alcohol, in ketoprofen-photoallergic patients is higher than in dermatitis patients.

OBJECTIVE: To explore the prevalence of contact allergy to FM I and its individual components in patients with photocontact allergy to ketoprofen, and to compare with a dermatitis and the general population.

METHODS: Data on patch and photopatch tests performed between 2009-2018 were collected. Ketoprofen-photoallergic patients were compared with dermatitis patients and published data on the general population regarding the prevalence and the... (More)

BACKGROUND: Contact allergy to fragrance mix I (FM I) is over-represented in patients photoallergic to ketoprofen. The prevalence of contact allergy to two components of FM I, cinnamal and cinnamyl alcohol, in ketoprofen-photoallergic patients is higher than in dermatitis patients.

OBJECTIVE: To explore the prevalence of contact allergy to FM I and its individual components in patients with photocontact allergy to ketoprofen, and to compare with a dermatitis and the general population.

METHODS: Data on patch and photopatch tests performed between 2009-2018 were collected. Ketoprofen-photoallergic patients were compared with dermatitis patients and published data on the general population regarding the prevalence and the distribution of contact allergy to FM I and its components.

RESULTS: A higher prevalence of contact allergy to cinnamyl alcohol compared to cinnamal (23.3% vs 10.0%), and eugenol compared to isoeugenol (23.3% vs 6.7%), was observed in ketoprofen-photoallergic patients, while the relationship was the opposite in dermatitis group (0.7% vs 1.05%; 0.4% vs 0.9%). Overall prevalence of contact allergy to several components of FM I was significantly higher in ketoprofen-photoallergic patients.

CONCLUSIONS: Contact allergy to FM I and many of its components is over-represented in patients photoallergic to ketoprofen compared to dermatitis patients and the general population. This article is protected by copyright. All rights reserved.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
volume
85
issue
6
pages
660 - 670
publisher
Wiley-Blackwell
external identifiers
  • pmid:34414573
  • scopus:85114332206
ISSN
0105-1873
DOI
10.1111/cod.13958
language
English
LU publication?
yes
id
dde7076d-a544-435c-ae43-6f607fb1d860
date added to LUP
2021-08-23 15:48:42
date last changed
2024-06-15 15:07:13
@article{dde7076d-a544-435c-ae43-6f607fb1d860,
  abstract     = {{<p>BACKGROUND: Contact allergy to fragrance mix I (FM I) is over-represented in patients photoallergic to ketoprofen. The prevalence of contact allergy to two components of FM I, cinnamal and cinnamyl alcohol, in ketoprofen-photoallergic patients is higher than in dermatitis patients.</p><p>OBJECTIVE: To explore the prevalence of contact allergy to FM I and its individual components in patients with photocontact allergy to ketoprofen, and to compare with a dermatitis and the general population.</p><p>METHODS: Data on patch and photopatch tests performed between 2009-2018 were collected. Ketoprofen-photoallergic patients were compared with dermatitis patients and published data on the general population regarding the prevalence and the distribution of contact allergy to FM I and its components.</p><p>RESULTS: A higher prevalence of contact allergy to cinnamyl alcohol compared to cinnamal (23.3% vs 10.0%), and eugenol compared to isoeugenol (23.3% vs 6.7%), was observed in ketoprofen-photoallergic patients, while the relationship was the opposite in dermatitis group (0.7% vs 1.05%; 0.4% vs 0.9%). Overall prevalence of contact allergy to several components of FM I was significantly higher in ketoprofen-photoallergic patients.</p><p>CONCLUSIONS: Contact allergy to FM I and many of its components is over-represented in patients photoallergic to ketoprofen compared to dermatitis patients and the general population. This article is protected by copyright. All rights reserved.</p>}},
  author       = {{Marmgren, Victoria and Mowitz, Martin and Zimerson, Erik and Hindsén, Monica and Bruze, Magnus}},
  issn         = {{0105-1873}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{660--670}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Contact allergy to fragrance mix I and its components in individuals with photocontact allergy to ketoprofen}},
  url          = {{http://dx.doi.org/10.1111/cod.13958}},
  doi          = {{10.1111/cod.13958}},
  volume       = {{85}},
  year         = {{2021}},
}