Changes of cartilage and bone markers after intraarticular glucocorticoid treatment with and without postinjection rest in patients with rheumatoid arthritis
(2005) In Annals of the Rheumatic Diseases 64(12). p.1750-1753- Abstract
- Background: Joint immobilisation improves the therapeutic effect of intra-articular glucocorticoid injection for knee synovitis. This may be due to retarded steroid resorption by immobilisation, a procedure that also could influence cartilage and bone metabolism. Objective: To evaluate changes in cartilage and bone turnover after intra-articular glucocorticoid treatment for knee synovitis with and without postinjection rest. Methods: 20 patients with rheumatoid arthritis and knee synovitis were randomised to 24 hour bed rest or to normal activity after intra-articular glucocorticoid treatment. Serum and urine markers of cartilage and bone turnover were studied for two weeks. Cartilage oligomeric matrix protein (COMP) was used as a marker... (More)
- Background: Joint immobilisation improves the therapeutic effect of intra-articular glucocorticoid injection for knee synovitis. This may be due to retarded steroid resorption by immobilisation, a procedure that also could influence cartilage and bone metabolism. Objective: To evaluate changes in cartilage and bone turnover after intra-articular glucocorticoid treatment for knee synovitis with and without postinjection rest. Methods: 20 patients with rheumatoid arthritis and knee synovitis were randomised to 24 hour bed rest or to normal activity after intra-articular glucocorticoid treatment. Serum and urine markers of cartilage and bone turnover were studied for two weeks. Cartilage oligomeric matrix protein (COMP) was used as a marker of cartilage turnover, osteocalcin as marker of bone formation, and deoxipyridinoline (DPD) as marker of bone resorption. Results: After the glucocorticoid injection COMP levels decreased in both groups (p < 0.001), but significantly more in resting patients. Serum osteocalcin levels decreased significantly (p < 0.001) without any difference between the groups. DPD was unchanged in both groups. Conclusions: Intra-articular glucocorticoid treatment for knee synovitis reduced serum COMP, which suggests that such treatment may have a cartilage protective effect. The slightly larger decrease of serum COMP in the resting group may reflect a lower clearance of COMP from the joint cavity. Serum osteocalcin was temporarily reduced, indicating a reversible suppression of bone formation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/213538
- author
- Weitoft, T ; Larsson, A ; Saxne, Tore LU and Ronnblom, L
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of the Rheumatic Diseases
- volume
- 64
- issue
- 12
- pages
- 1750 - 1753
- publisher
- BMJ Publishing Group
- external identifiers
-
- wos:000233241000015
- pmid:15843449
- scopus:27944490312
- ISSN
- 1468-2060
- DOI
- 10.1136/ard.2004.035022
- language
- English
- LU publication?
- yes
- id
- de635f40-9eeb-4a64-b4f7-3933189b587a (old id 213538)
- date added to LUP
- 2016-04-01 15:22:41
- date last changed
- 2022-01-28 05:05:07
@article{de635f40-9eeb-4a64-b4f7-3933189b587a,
abstract = {{Background: Joint immobilisation improves the therapeutic effect of intra-articular glucocorticoid injection for knee synovitis. This may be due to retarded steroid resorption by immobilisation, a procedure that also could influence cartilage and bone metabolism. Objective: To evaluate changes in cartilage and bone turnover after intra-articular glucocorticoid treatment for knee synovitis with and without postinjection rest. Methods: 20 patients with rheumatoid arthritis and knee synovitis were randomised to 24 hour bed rest or to normal activity after intra-articular glucocorticoid treatment. Serum and urine markers of cartilage and bone turnover were studied for two weeks. Cartilage oligomeric matrix protein (COMP) was used as a marker of cartilage turnover, osteocalcin as marker of bone formation, and deoxipyridinoline (DPD) as marker of bone resorption. Results: After the glucocorticoid injection COMP levels decreased in both groups (p < 0.001), but significantly more in resting patients. Serum osteocalcin levels decreased significantly (p < 0.001) without any difference between the groups. DPD was unchanged in both groups. Conclusions: Intra-articular glucocorticoid treatment for knee synovitis reduced serum COMP, which suggests that such treatment may have a cartilage protective effect. The slightly larger decrease of serum COMP in the resting group may reflect a lower clearance of COMP from the joint cavity. Serum osteocalcin was temporarily reduced, indicating a reversible suppression of bone formation.}},
author = {{Weitoft, T and Larsson, A and Saxne, Tore and Ronnblom, L}},
issn = {{1468-2060}},
language = {{eng}},
number = {{12}},
pages = {{1750--1753}},
publisher = {{BMJ Publishing Group}},
series = {{Annals of the Rheumatic Diseases}},
title = {{Changes of cartilage and bone markers after intraarticular glucocorticoid treatment with and without postinjection rest in patients with rheumatoid arthritis}},
url = {{http://dx.doi.org/10.1136/ard.2004.035022}},
doi = {{10.1136/ard.2004.035022}},
volume = {{64}},
year = {{2005}},
}