Long term follow up of chronic hepatitis B virus infection in intravenous drug abusers and homosexual men
(1986) In BMJ: British Medical Journal 292(6524). p.854-857- Abstract
- Long term follow up of 16 homosexual men and 78 intravenous drug abusers who were chronic carriers of hepatitis B surface antigen (HBsAg) showed fundamental differences between the two groups. Viral replication, expressed by the presence of hepatitis B e antigen, lasted for four years or more in 10 out of 14 (71%) of the homosexual men whereas it was not present in 43 out of 73 (59%) of the drug addicts within one year. This shows a difference in the immunological response between homosexual HBsAg carriers and addicts that is not related to infection with human T cell lymphotropic virus type III. Severe histological damage such as chronic aggressive hepatitis, cirrhosis, or primary liver cancer was found in more than half of the homosexual... (More)
- Long term follow up of 16 homosexual men and 78 intravenous drug abusers who were chronic carriers of hepatitis B surface antigen (HBsAg) showed fundamental differences between the two groups. Viral replication, expressed by the presence of hepatitis B e antigen, lasted for four years or more in 10 out of 14 (71%) of the homosexual men whereas it was not present in 43 out of 73 (59%) of the drug addicts within one year. This shows a difference in the immunological response between homosexual HBsAg carriers and addicts that is not related to infection with human T cell lymphotropic virus type III. Severe histological damage such as chronic aggressive hepatitis, cirrhosis, or primary liver cancer was found in more than half of the homosexual men who underwent biopsy examinations. In drug addicts chronic persistent hepatitis was a regular finding in the absence of markers of delta infection, but in those addicts infected with the delta agent the degree of liver damage was comparable with that found in homosexual men. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103492
- author
- Moestrup, T ; Hansson, Bengt-Göran LU ; Widell, Anders LU ; Nordenfelt, Erik and Hägerstrand, Inga
- organization
- publishing date
- 1986
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMJ: British Medical Journal
- volume
- 292
- issue
- 6524
- pages
- 854 - 857
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:3083909
- scopus:0022598471
- ISSN
- 1756-1833
- language
- English
- LU publication?
- yes
- id
- de66a93b-1594-4340-b9c4-beaf1b1f71f6 (old id 1103492)
- alternative location
- http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1339968&blobtype=pdf
- date added to LUP
- 2016-04-01 15:55:03
- date last changed
- 2021-01-03 05:44:56
@article{de66a93b-1594-4340-b9c4-beaf1b1f71f6, abstract = {{Long term follow up of 16 homosexual men and 78 intravenous drug abusers who were chronic carriers of hepatitis B surface antigen (HBsAg) showed fundamental differences between the two groups. Viral replication, expressed by the presence of hepatitis B e antigen, lasted for four years or more in 10 out of 14 (71%) of the homosexual men whereas it was not present in 43 out of 73 (59%) of the drug addicts within one year. This shows a difference in the immunological response between homosexual HBsAg carriers and addicts that is not related to infection with human T cell lymphotropic virus type III. Severe histological damage such as chronic aggressive hepatitis, cirrhosis, or primary liver cancer was found in more than half of the homosexual men who underwent biopsy examinations. In drug addicts chronic persistent hepatitis was a regular finding in the absence of markers of delta infection, but in those addicts infected with the delta agent the degree of liver damage was comparable with that found in homosexual men.}}, author = {{Moestrup, T and Hansson, Bengt-Göran and Widell, Anders and Nordenfelt, Erik and Hägerstrand, Inga}}, issn = {{1756-1833}}, language = {{eng}}, number = {{6524}}, pages = {{854--857}}, publisher = {{BMJ Publishing Group}}, series = {{BMJ: British Medical Journal}}, title = {{Long term follow up of chronic hepatitis B virus infection in intravenous drug abusers and homosexual men}}, url = {{http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1339968&blobtype=pdf}}, volume = {{292}}, year = {{1986}}, }