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Association between HLA and islet cell antibodies in diabetic patients with a mitochondrial DNA mutation at base pair 3243

Kobayashi, T. ; Oka, Y. ; Katagiri, H. ; Falornl, A. ; Kasiiga, A. ; Takei, I. ; Nuakanishi, K. ; Murase, T. ; Kosaka, K. and Lernmark, A. LU (1996) In Diabetologia 39(10). p.1196-1200
Abstract

Islet cell antibodies (ICA), autoantibodies to glutamic acid decarboxylase (GAD) and HLA genotypes were examined in 31 patients with diabetes and a mitochondria! gene mutation located at base pair 3243 (mtDNA 3243 mutation). ICA was detected in 42 % (13/31) of these patients compared to 0 of 90 among healthy control subjects. The ICA showed a "non-restricted" pattern of staining in all 13 ICA-positive patients. In a sensitive radioligand assay only 2 of 31 (6 %) diabetic patients with the mutation were positive for both GAD65 autoantibodies and ICA, while the remaining 29 patients were GAD65 antibody negative. The ICA-positive patients had an increased frequency of the HLADQA1*0301 allele compared to control subjects (p < 0.05). Of... (More)

Islet cell antibodies (ICA), autoantibodies to glutamic acid decarboxylase (GAD) and HLA genotypes were examined in 31 patients with diabetes and a mitochondria! gene mutation located at base pair 3243 (mtDNA 3243 mutation). ICA was detected in 42 % (13/31) of these patients compared to 0 of 90 among healthy control subjects. The ICA showed a "non-restricted" pattern of staining in all 13 ICA-positive patients. In a sensitive radioligand assay only 2 of 31 (6 %) diabetic patients with the mutation were positive for both GAD65 autoantibodies and ICA, while the remaining 29 patients were GAD65 antibody negative. The ICA-positive patients had an increased frequency of the HLADQA1*0301 allele compared to control subjects (p < 0.05). Of the diabetic patients with the mutation 45% (14/31) had progressive clinical course of betacell failure. These results indicate thai patients with an mtDNA 3243 mutation may develop islet autoimmunity associated with ICA and GAD autoantibodies. We hypothesize that the presence of HLADQA1*0301 in individuals with the mtDNA 3243 mutation increases the risk for diabetes and associated autoantibodies against islet cell antieens.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoantibodies to glulamic acid decarboxylase (GAD), HLA, Insulin-dependent diabetes mellitus, Islet cell antibodies, Mitochondrial gene mutation
in
Diabetologia
volume
39
issue
10
pages
1196 - 1200
publisher
Springer
external identifiers
  • pmid:8897007
  • scopus:0030256832
ISSN
0012-186X
DOI
10.1007/BF02658506
language
English
LU publication?
no
id
de7dc2f3-7c2b-454d-bbe0-e9eb0deddf31
date added to LUP
2019-07-01 13:21:55
date last changed
2021-03-24 06:06:19
@article{de7dc2f3-7c2b-454d-bbe0-e9eb0deddf31,
  abstract     = {<p>Islet cell antibodies (ICA), autoantibodies to glutamic acid decarboxylase (GAD) and HLA genotypes were examined in 31 patients with diabetes and a mitochondria! gene mutation located at base pair 3243 (mtDNA 3243 mutation). ICA was detected in 42 % (13/31) of these patients compared to 0 of 90 among healthy control subjects. The ICA showed a "non-restricted" pattern of staining in all 13 ICA-positive patients. In a sensitive radioligand assay only 2 of 31 (6 %) diabetic patients with the mutation were positive for both GAD65 autoantibodies and ICA, while the remaining 29 patients were GAD65 antibody negative. The ICA-positive patients had an increased frequency of the HLADQA1*0301 allele compared to control subjects (p &lt; 0.05). Of the diabetic patients with the mutation 45% (14/31) had progressive clinical course of betacell failure. These results indicate thai patients with an mtDNA 3243 mutation may develop islet autoimmunity associated with ICA and GAD autoantibodies. We hypothesize that the presence of HLADQA1*0301 in individuals with the mtDNA 3243 mutation increases the risk for diabetes and associated autoantibodies against islet cell antieens.</p>},
  author       = {Kobayashi, T. and Oka, Y. and Katagiri, H. and Falornl, A. and Kasiiga, A. and Takei, I. and Nuakanishi, K. and Murase, T. and Kosaka, K. and Lernmark, A.},
  issn         = {0012-186X},
  language     = {eng},
  month        = {01},
  number       = {10},
  pages        = {1196--1200},
  publisher    = {Springer},
  series       = {Diabetologia},
  title        = {Association between HLA and islet cell antibodies in diabetic patients with a mitochondrial DNA mutation at base pair 3243},
  url          = {http://dx.doi.org/10.1007/BF02658506},
  doi          = {10.1007/BF02658506},
  volume       = {39},
  year         = {1996},
}